Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CSF3R	5件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D03235	Filgrastim	35件: 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 6 ...
2	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D10172	Teriflunomide	3件: 13, 25, 26
3	NR3C1	1件: Neuroactive ligand-receptor interaction	D00407	Methylprednisolone	40件: 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, ...
4	NR3C1	1件: Neuroactive ligand-receptor interaction	D00472	Prednisolone	38件: 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, ...
5	IFNAR1	18件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast dif ...	D02745	Interferon alfa-2b	2件: 25, 34
6	IFNAR1	18件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast dif ...	D03305	Interferon alfa	6件: 13, 25, 26, 28, 56, 96
7	IFNAR2	17件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast dif ...	D02745	Interferon alfa-2b	2件: 25, 34
8	IFNAR2	17件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast dif ...	D03305	Interferon alfa	6件: 13, 25, 26, 28, 56, 96
9	ITGA4	14件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D06886	Natalizumab	6件: 13, 15, 25, 46, 63, 96
10	PDCD1	3件: Cell adhesion molecules, T cell receptor signaling pathway, PD-L1 expression and PD-1 checkpoint ...	D10574	Pembrolizumab	2件: 25, 285

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