Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CSF3R	5件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D03235	Filgrastim	35件: 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 6 ...
2	ADRB2	9件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...	D02147	Salbutamol	12件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299
3	ADRB2	9件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...	D07713	Clenbuterol	5件: 1, 2, 6, 13, 256
4	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
5	ABAT	7件: Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...	D00399	Valproic acid	14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
6	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
7	MTOR	51件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...	D00753	Sirolimus	40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...
8	GAA	4件: Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, Lysosome	D03207	Alglucosidase alfa	1件: 256
9	GAA	4件: Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, Lysosome	D09605	Duvoglustat	1件: 256
10	GAA	4件: Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, Lysosome	D11744	Avalglucosidase alfa	1件: 256

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