Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
3	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
4	FDPS	4件: Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...	D01968	Zoledronic acid	13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
5	FDPS	4件: Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...	D07281	Pamidronic acid	3件: 270, 271, 274
6	FDPS	4件: Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...	D08689	Zoledronic acid	13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
7	LTA	7件: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine rec ...	D00742	Etanercept	16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
8	TNF	67件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral pr ...	D00742	Etanercept	16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
9	TNF	67件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral pr ...	D02597	Adalimumab	17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
10	TNF	67件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral pr ...	D02598	Infliximab	27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 1 ...

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