Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	IL17F	4件: Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Infl ...	D11550	Bimekizumab	3件: 46, 97, 271
2	CNR1	4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...	D00306	Dronabinol	8件: 2, 8, 13, 36, 46, 96, 271, 298
3	CNR1	4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...	D10915	Cannabidiol	20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
4	CNR2	1件: Neuroactive ligand-receptor interaction	D00306	Dronabinol	2件: 271, 298
5	CNR2	1件: Neuroactive ligand-receptor interaction	D10915	Cannabidiol	1件: 271
6	ACE	6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00251	Captopril	8件: 6, 17, 46, 86, 96, 97, 107, 271
7	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
8	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
9	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
10	FDPS	4件: Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...	D07119	Alendronic acid	7件: 19, 41, 46, 50, 271, 274, 299

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