Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	IL17RA	3件: Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Alcoholic liver disease	D10061	Brodalumab	2件: 37, 51
2	HPRT1	4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	D08603	Tioguanine	2件: 13, 37
3	IL1R1	13件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, O ...	D02934	Anakinra	18件: 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
4	IL12A	25件: Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like recept ...	D09214	Ustekinumab	16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
5	IL12B	25件: Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like recept ...	D09214	Ustekinumab	16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
6	IL17A	6件: Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Alco ...	D09967	Secukinumab	8件: 13, 37, 41, 46, 107, 160, 269, 271
7	IL17A	6件: Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Alco ...	D10071	Ixekizumab	8件: 36, 37, 46, 107, 160, 162, 269, 271
8	ITGAL	12件: Rap1 signaling pathway, Cell adhesion molecules, Neutrophil extracellular trap formation, Natur ...	D03959	Efalizumab	9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
9	MTNR1A	2件: Neuroactive ligand-receptor interaction, Circadian entrainment	D08170	Melatonin	12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202
10	MTNR1B	2件: Neuroactive ligand-receptor interaction, Circadian entrainment	D08170	Melatonin	12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202

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