Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CD52	-	D02802	Alemtuzumab	17件: 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326
2	TNFSF13B	4件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network ...	D03068	Belimumab	13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300
3	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
4	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
5	NR3C1	1件: Neuroactive ligand-receptor interaction	D00407	Methylprednisolone	32件: 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, ...
6	NR3C1	1件: Neuroactive ligand-receptor interaction	D00472	Prednisolone	31件: 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 1 ...
7	NR3C1	1件: Neuroactive ligand-receptor interaction	D00473	Prednisone	35件: 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 1 ...
8	IL6R	12件: EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protei ...	D02596	Tocilizumab	21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
9	IMPDH1	4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	D00752	Mycophenolate mofetil	34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, ...
10	IMPDH1	4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	D05096	Mycophenolic acid	36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, ...

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