Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2 ADORA1 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
3 ADORA1 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
4 ADORA2A 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
5 ADORA2A 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
6 ADRA2A 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00281 Clonidine 4件: 6, 65, 70, 78
7 ADRA2B 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00281 Clonidine 4件: 6, 65, 70, 78
8 ADRA2C 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction D00281 Clonidine 4件: 6, 65, 70, 78
9 CYP19A1 3件: Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D00960 Anastrozole 3件: 78, 86, 193
10 GHR 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action D03297 Mecasermin 6件: 65, 78, 96, 168, 265, 299
11 GHR 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action D05394 Pegvisomant 2件: 78, 265
12 GHR 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action D11193 Somavaratan 1件: 78
13 GHR 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action D11194 Somapacitan 2件: 78, 195
14 GHR 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action D11486 Lonapegsomatropin 1件: 78
15 GHRHR 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D06655 Tesamorelin 2件: 78, 265
16 GHRHR 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D08523 Somatorelin 2件: 13, 78
17 GHSR 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10563 Macimorelin 1件: 78
18 GLP1R 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion D04121 Exenatide 6件: 6, 17, 72, 78, 193, 233
19 GRIN1 18件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
20 GRIN2A 19件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
21 GRIN2B 19件: Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
22 GRIN2C 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
23 GRIN2D 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
24 NR3C1 1件: Neuroactive ligand-receptor interaction D00088 Hydrocortisone 5件: 78, 81, 83, 97, 299
25 IGF1R 29件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma D03297 Mecasermin 6件: 65, 78, 96, 168, 265, 299
26 AR 4件: Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer D00075 Testosterone 8件: 1, 2, 3, 13, 60, 76, 78, 113
27 MC2R 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome D00284 Tetracosactide 5件: 78, 83, 113, 145, 222
28 ACHE 2件: Glycerophospholipid metabolism, Cholinergic synapse D07869 Donepezil 9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
29 MTNR1A 2件: Neuroactive ligand-receptor interaction, Circadian entrainment D08170 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202
30 MTNR1B 2件: Neuroactive ligand-receptor interaction, Circadian entrainment D08170 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202
31 OPRM1 3件: Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08623 Tramadol 5件: 46, 70, 78, 226, 271
32 PDE2A 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
33 PDE2A 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
34 PDE3A 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
35 PDE3A 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
36 PDE3B 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
37 PDE3B 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
38 PDE4A 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
39 PDE4A 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
40 PDE4B 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
41 PDE4B 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
42 PDE4C 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
43 PDE4C 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
44 PDE4D 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
45 PDE4D 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
46 PDE1B 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
47 PDE1B 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
48 PPARG 11件: PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis D08378 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
49 PTGS1 5件: Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D07816 Diclofenac 5件: 13, 34, 46, 78, 271
50 PTGS2 22件: Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer D07816 Diclofenac 5件: 13, 34, 46, 78, 271
51 SLC6A2 1件: Synaptic vesicle cycle D07448 Amitriptyline 4件: 78, 97, 226, 299
52 SLC6A4 2件: Synaptic vesicle cycle, Serotonergic synapse D00326 Fluoxetine 6件: 13, 17, 78, 86, 179, 206
53 SLC6A4 2件: Synaptic vesicle cycle, Serotonergic synapse D07448 Amitriptyline 4件: 78, 97, 226, 299
54 SSTR1 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin 2件: 67, 78
55 SSTR2 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin 2件: 67, 78
56 SSTR3 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin 2件: 67, 78
57 SSTR4 1件: Neuroactive ligand-receptor interaction D07431 Somatostatin 1件: 78
58 SSTR5 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin 2件: 67, 78
59 THRA 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D07214 Tiratricol 2件: 78, 139
60 THRA 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
61 THRA 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D08128 Liothyronine 4件: 13, 78, 210, 212
62 THRB 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D07214 Tiratricol 2件: 78, 139
63 THRB 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
64 THRB 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway D08128 Liothyronine 4件: 13, 78, 210, 212
65 PDE5A 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
66 PDE5A 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265