Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CDK4	12件: p53 signaling pathway, PI3K-Akt signaling pathway, Tight junction, T cell receptor signaling pa ...	D10688	Abemaciclib	1件: 34
2	CDK6	11件: p53 signaling pathway, PI3K-Akt signaling pathway, Measles, Kaposi sarcoma-associated herpesvir ...	D10688	Abemaciclib	1件: 34
3	CCR4	3件: Viral protein interaction with cytokine and cytokine receptor, Kaposi sarcoma-associated herpesv ...	D09761	Mogamulizumab	1件: 26
4	CCR5	6件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with ...	D06670	Maraviroc	2件: 46, 84
5	CCR5	6件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with ...	D09878	Cenicriviroc	1件: 94
6	MAPK14	38件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D09639	Losmapimod	2件: 113, 222
7	MAPK14	38件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D10959	Neflamapimod	1件: 8
8	CSF2	7件: Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling path ...	D11343	Otilimab	1件: 46
9	MTOR	20件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D00753	Sirolimus	40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...
10	MTOR	20件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D02714	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277

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