Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 PDE10A 1件: Purine metabolism D00227 Aminophylline 1件: 63
2 PDE10A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
3 PDE10A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
4 PDE10A 1件: Purine metabolism D07546 Bucladesine 1件: 246
5 PDE10A 1件: Purine metabolism D07961 Flavoxate 1件: 226
6 PDE7B 1件: Purine metabolism D00227 Aminophylline 1件: 63
7 PDE7B 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
8 PDE7B 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
9 PDE7B 1件: Purine metabolism D07546 Bucladesine 1件: 246
10 PDE7B 1件: Purine metabolism D07961 Flavoxate 1件: 226
11 GUCY1A2 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
12 GUCY1A2 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
13 GUCY1A1 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
14 GUCY1A1 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
15 GUCY1B1 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
16 GUCY1B1 4件: Purine metabolism, Vascular smooth muscle contraction, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
17 GUCY2C 1件: Purine metabolism D09355 Linaclotide 2件: 6, 97
18 HPRT1 1件: Purine metabolism D00161 Mercaptopurine 4件: 65, 96, 97, 164
19 HPRT1 1件: Purine metabolism D04931 Mercaptopurine 4件: 65, 96, 97, 164
20 HPRT1 1件: Purine metabolism D08603 Tioguanine 2件: 13, 37
21 IMPDH1 1件: Purine metabolism D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
22 IMPDH1 1件: Purine metabolism D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
23 IMPDH1 1件: Purine metabolism D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
24 IMPDH2 1件: Purine metabolism D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
25 IMPDH2 1件: Purine metabolism D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
26 IMPDH2 1件: Purine metabolism D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
27 NPR1 5件: Purine metabolism, Vascular smooth muscle contraction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion D04051 Erythrityl tetranitrate 1件: 46
28 NPR1 5件: Purine metabolism, Vascular smooth muscle contraction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion D05147 Nesiritide 2件: 46, 58
29 NPR2 2件: Purine metabolism, Vascular smooth muscle contraction D04051 Erythrityl tetranitrate 1件: 46
30 NPR2 2件: Purine metabolism, Vascular smooth muscle contraction D11190 Vosoritide 1件: 276
31 PDE11A 1件: Purine metabolism D00227 Aminophylline 1件: 63
32 PDE11A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
33 PDE11A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
34 PDE11A 1件: Purine metabolism D07546 Bucladesine 1件: 246
35 PDE11A 1件: Purine metabolism D07961 Flavoxate 1件: 226
36 PDE1A 3件: Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline 1件: 63
37 PDE1A 3件: Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline 2件: 236, 299
38 PDE1A 3件: Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline 2件: 236, 299
39 PDE1A 3件: Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine 1件: 246
40 PDE1A 3件: Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate 1件: 226
41 PDE1C 3件: Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline 1件: 63
42 PDE1C 3件: Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline 2件: 236, 299
43 PDE1C 3件: Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline 2件: 236, 299
44 PDE1C 3件: Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine 1件: 246
45 PDE1C 3件: Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate 1件: 226
46 PDE2A 1件: Purine metabolism D00227 Aminophylline 1件: 63
47 PDE2A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
48 PDE2A 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
49 PDE2A 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
50 PDE2A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
51 PDE2A 1件: Purine metabolism D07546 Bucladesine 1件: 246
52 PDE2A 1件: Purine metabolism D07961 Flavoxate 1件: 226
53 PDE3A 2件: Purine metabolism, Renin secretion D00227 Aminophylline 1件: 63
54 PDE3A 2件: Purine metabolism, Renin secretion D00371 Theophylline 2件: 236, 299
55 PDE3A 2件: Purine metabolism, Renin secretion D00417 Milrinone 1件: 294
56 PDE3A 2件: Purine metabolism, Renin secretion D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
57 PDE3A 2件: Purine metabolism, Renin secretion D01385 Ibudilast 2件: 2, 13
58 PDE3A 2件: Purine metabolism, Renin secretion D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
59 PDE3A 2件: Purine metabolism, Renin secretion D01896 Cilostazol 3件: 46, 51, 70
60 PDE3A 2件: Purine metabolism, Renin secretion D04720 Levosimendan 1件: 2
61 PDE3A 2件: Purine metabolism, Renin secretion D06103 Theophylline 2件: 236, 299
62 PDE3A 2件: Purine metabolism, Renin secretion D07546 Bucladesine 1件: 246
63 PDE3A 2件: Purine metabolism, Renin secretion D07961 Flavoxate 1件: 226
64 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00227 Aminophylline 1件: 63
65 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00371 Theophylline 2件: 236, 299
66 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00417 Milrinone 1件: 294
67 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
68 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01385 Ibudilast 2件: 2, 13
69 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
70 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D01896 Cilostazol 3件: 46, 51, 70
71 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D04720 Levosimendan 1件: 2
72 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D06103 Theophylline 2件: 236, 299
73 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D07546 Bucladesine 1件: 246
74 PDE3B 3件: Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion D07961 Flavoxate 1件: 226
75 PDE4A 1件: Purine metabolism D00227 Aminophylline 1件: 63
76 PDE4A 1件: Purine metabolism D00302 Dipyridamole 6件: 46, 49, 51, 66, 96, 224
77 PDE4A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
78 PDE4A 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
79 PDE4A 1件: Purine metabolism D01385 Ibudilast 2件: 2, 13
80 PDE4A 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
81 PDE4A 1件: Purine metabolism D01783 Rolipram 2件: 8, 13
82 PDE4A 1件: Purine metabolism D05744 Roflumilast 4件: 84, 97, 206, 299
83 PDE4A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
84 PDE4A 1件: Purine metabolism D07546 Bucladesine 1件: 246
85 PDE4A 1件: Purine metabolism D07961 Flavoxate 1件: 226
86 PDE4A 1件: Purine metabolism D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
87 PDE4B 1件: Purine metabolism D00227 Aminophylline 1件: 63
88 PDE4B 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
89 PDE4B 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
90 PDE4B 1件: Purine metabolism D01385 Ibudilast 2件: 2, 13
91 PDE4B 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
92 PDE4B 1件: Purine metabolism D01783 Rolipram 2件: 8, 13
93 PDE4B 1件: Purine metabolism D05744 Roflumilast 4件: 84, 97, 206, 299
94 PDE4B 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
95 PDE4B 1件: Purine metabolism D07546 Bucladesine 1件: 246
96 PDE4B 1件: Purine metabolism D07961 Flavoxate 1件: 226
97 PDE4B 1件: Purine metabolism D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
98 PDE4C 1件: Purine metabolism D00227 Aminophylline 1件: 63
99 PDE4C 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
100 PDE4C 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
101 PDE4C 1件: Purine metabolism D01385 Ibudilast 2件: 2, 13
102 PDE4C 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
103 PDE4C 1件: Purine metabolism D01783 Rolipram 2件: 8, 13
104 PDE4C 1件: Purine metabolism D05744 Roflumilast 4件: 84, 97, 206, 299
105 PDE4C 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
106 PDE4C 1件: Purine metabolism D07546 Bucladesine 1件: 246
107 PDE4C 1件: Purine metabolism D07961 Flavoxate 1件: 226
108 PDE4C 1件: Purine metabolism D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
109 PDE4D 1件: Purine metabolism D00227 Aminophylline 1件: 63
110 PDE4D 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
111 PDE4D 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
112 PDE4D 1件: Purine metabolism D01385 Ibudilast 2件: 2, 13
113 PDE4D 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
114 PDE4D 1件: Purine metabolism D01783 Rolipram 2件: 8, 13
115 PDE4D 1件: Purine metabolism D05744 Roflumilast 4件: 84, 97, 206, 299
116 PDE4D 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
117 PDE4D 1件: Purine metabolism D07546 Bucladesine 1件: 246
118 PDE4D 1件: Purine metabolism D07961 Flavoxate 1件: 226
119 PDE4D 1件: Purine metabolism D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
120 PDE4D 1件: Purine metabolism D12173 Zatolmilast 1件: 206
121 PDE7A 1件: Purine metabolism D00227 Aminophylline 1件: 63
122 PDE7A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
123 PDE7A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
124 PDE7A 1件: Purine metabolism D07546 Bucladesine 1件: 246
125 PDE7A 1件: Purine metabolism D07961 Flavoxate 1件: 226
126 PDE8A 1件: Purine metabolism D00227 Aminophylline 1件: 63
127 PDE8A 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
128 PDE8A 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
129 PDE8A 1件: Purine metabolism D07546 Bucladesine 1件: 246
130 PDE8A 1件: Purine metabolism D07961 Flavoxate 1件: 226
131 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D00227 Aminophylline 1件: 63
132 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D00371 Theophylline 2件: 236, 299
133 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
134 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
135 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D06103 Theophylline 2件: 236, 299
136 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D07546 Bucladesine 1件: 246
137 PDE1B 3件: Purine metabolism, Taste transduction, Renin secretion D07961 Flavoxate 1件: 226
138 RRM1 2件: Purine metabolism, Pyrimidine metabolism D01370 Cladribine 3件: 11, 13, 94
139 RRM1 2件: Purine metabolism, Pyrimidine metabolism D03546 Clofarabine 5件: 19, 20, 60, 234, 326
140 RRM1 2件: Purine metabolism, Pyrimidine metabolism D07966 Fludarabine 20件: 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
141 RRM2 2件: Purine metabolism, Pyrimidine metabolism D00341 Hydroxyurea 8件: 3, 13, 19, 20, 65, 85, 86, 284
142 XDH 1件: Purine metabolism D00224 Allopurinol 7件: 6, 46, 57, 60, 66, 96, 97
143 XDH 1件: Purine metabolism D01206 Febuxostat 3件: 2, 6, 13
144 PDE8B 1件: Purine metabolism D00227 Aminophylline 1件: 63
145 PDE8B 1件: Purine metabolism D00371 Theophylline 2件: 236, 299
146 PDE8B 1件: Purine metabolism D06103 Theophylline 2件: 236, 299
147 PDE8B 1件: Purine metabolism D07546 Bucladesine 1件: 246
148 PDE8B 1件: Purine metabolism D07961 Flavoxate 1件: 226
149 PDE5A 1件: Purine metabolism D00302 Dipyridamole 6件: 46, 49, 51, 66, 96, 224
150 PDE5A 1件: Purine metabolism D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
151 PDE5A 1件: Purine metabolism D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
152 PDE5A 1件: Purine metabolism D02008 Tadalafil 7件: 6, 51, 75, 84, 86, 113, 210
153 PDE5A 1件: Purine metabolism D08514 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
154 PDE5A 1件: Purine metabolism D08668 Vardenafil 3件: 13, 86, 299
155 PDE5A 1件: Purine metabolism D10027 Udenafil 2件: 86, 210