Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ADORA1 1件: Sphingolipid signaling pathway D00045 Adenosine 3件: 13, 58, 65
2 ADORA1 1件: Sphingolipid signaling pathway D00227 Aminophylline 1件: 63
3 ADORA1 1件: Sphingolipid signaling pathway D00371 Theophylline 2件: 236, 299
4 ADORA1 1件: Sphingolipid signaling pathway D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
5 ADORA1 1件: Sphingolipid signaling pathway D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
6 ADORA1 1件: Sphingolipid signaling pathway D02769 Adenosine phosphate 1件: 46
7 ADORA1 1件: Sphingolipid signaling pathway D06103 Theophylline 2件: 236, 299
8 ADORA3 1件: Sphingolipid signaling pathway D00045 Adenosine 3件: 13, 58, 65
9 ADORA3 1件: Sphingolipid signaling pathway D02769 Adenosine phosphate 1件: 46
10 ADORA3 1件: Sphingolipid signaling pathway D10971 Piclidenoson 1件: 46
11 MAPK14 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
12 MAPK14 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
13 S1PR1 1件: Sphingolipid signaling pathway D10001 Fingolimod 3件: 13, 14, 156
14 S1PR1 1件: Sphingolipid signaling pathway D10905 Amiselimod 1件: 97
15 S1PR1 1件: Sphingolipid signaling pathway D10930 Etrasimod 3件: 96, 97, 98
16 S1PR1 1件: Sphingolipid signaling pathway D10968 Ozanimod 3件: 13, 96, 97
17 S1PR1 1件: Sphingolipid signaling pathway D11215 Ponesimod 1件: 13
18 S1PR1 1件: Sphingolipid signaling pathway D11283 Cenerimod 1件: 49
19 S1PR1 1件: Sphingolipid signaling pathway D11460 Siponimod 2件: 13, 50
20 S1PR3 1件: Sphingolipid signaling pathway D10905 Amiselimod 1件: 97
21 S1PR3 1件: Sphingolipid signaling pathway D10930 Etrasimod 3件: 96, 97, 98
22 S1PR3 1件: Sphingolipid signaling pathway D10968 Ozanimod 3件: 13, 96, 97
23 FCER1A 1件: Sphingolipid signaling pathway D05251 Omalizumab 7件: 46, 53, 65, 98, 162, 226, 299
24 FYN 3件: Sphingolipid signaling pathway, T cell receptor signaling pathway, Viral myocarditis D03658 Dasatinib 2件: 51, 85
25 FYN 3件: Sphingolipid signaling pathway, T cell receptor signaling pathway, Viral myocarditis D06414 Dasatinib 2件: 51, 85
26 MAP3K5 5件: Sphingolipid signaling pathway, Tight junction, TNF signaling pathway, Thermogenesis, Spinocerebellar ataxia D10988 Selonsertib 1件: 86
27 NFKB1 11件: Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod 5件: 46, 51, 53, 271, 300
28 OPRD1 1件: Sphingolipid signaling pathway D05111 Nalmefene 1件: 6
29 OPRD1 1件: Sphingolipid signaling pathway D05113 Naltrexone 13件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
30 OPRD1 1件: Sphingolipid signaling pathway D05312 Oxycodone 5件: 6, 13, 70, 226, 298
31 OPRD1 1件: Sphingolipid signaling pathway D08144 Loperamide 2件: 13, 97
32 OPRD1 1件: Sphingolipid signaling pathway D08246 Nalbuphine 1件: 85
33 OPRD1 1件: Sphingolipid signaling pathway D08249 Naloxone 2件: 6, 226
34 PIK3CA 10件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11011 Alpelisib 1件: 138
35 PIK3CA 10件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
36 PIK3CB 10件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
37 PIK3CD 10件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
38 PIK3CD 10件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
39 S1PR5 1件: Sphingolipid signaling pathway D10905 Amiselimod 1件: 97
40 S1PR5 1件: Sphingolipid signaling pathway D10930 Etrasimod 3件: 96, 97, 98
41 S1PR5 1件: Sphingolipid signaling pathway D10968 Ozanimod 3件: 13, 96, 97
42 S1PR5 1件: Sphingolipid signaling pathway D11460 Siponimod 2件: 13, 50
43 PRKCB 7件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Spinocerebellar ataxia D11935 Enzastaurin 1件: 168
44 PRKCE 4件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Type II diabetes mellitus D09671 Sotrastaurin 1件: 97
45 MAPK11 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
46 MAPK11 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
47 MAPK13 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
48 MAPK13 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
49 MAP2K1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D09666 Selumetinib 1件: 34
50 MAP2K1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
51 MAP2K1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10405 Cobimetinib 1件: 280
52 MAP2K1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10604 Binimetinib 1件: 34
53 MAP2K1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D11675 Mirdametinib 1件: 34
54 MAP2K2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D09666 Selumetinib 1件: 34
55 MAP2K2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
56 MAP2K2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10405 Cobimetinib 1件: 280
57 MAP2K2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10604 Binimetinib 1件: 34
58 MAP2K2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D11675 Mirdametinib 1件: 34
59 RAF1 6件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Tuberculosis D08524 Sorafenib 2件: 34, 86
60 BCL2 3件: Sphingolipid signaling pathway, Toxoplasmosis, Tuberculosis D10679 Venetoclax 1件: 28
61 RELA 11件: Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent 1件: 113
62 ROCK1 5件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
63 MAPK12 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
64 MAPK12 11件: Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
65 SMPD1 1件: Sphingolipid signaling pathway D10820 Olipudase alfa 1件: 19
66 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
67 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
68 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
69 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02597 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
70 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
71 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
72 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
73 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
74 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D05393 Pegsunercept 1件: 46
75 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
76 TNF 12件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D09944 Ozoralizumab 1件: 46
77 S1PR4 1件: Sphingolipid signaling pathway D10905 Amiselimod 1件: 97
78 S1PR4 1件: Sphingolipid signaling pathway D10930 Etrasimod 3件: 96, 97, 98
79 S1PR4 1件: Sphingolipid signaling pathway D10968 Ozanimod 3件: 13, 96, 97
80 S1PR2 1件: Sphingolipid signaling pathway D10905 Amiselimod 1件: 97
81 S1PR2 1件: Sphingolipid signaling pathway D10930 Etrasimod 3件: 96, 97, 98
82 S1PR2 1件: Sphingolipid signaling pathway D10968 Ozanimod 3件: 13, 96, 97
83 ROCK2 5件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
84 ROCK2 5件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Yersinia infection D11815 Belumosudil 2件: 51, 85