Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	58件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	58件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	1件: 8
3	IL1B	38件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, N ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
4	IL1B	38件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, N ...	D06635	Rilonacept	4件: 51, 106, 107, 266
5	IL1B	38件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, N ...	D09315	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
6	IL1B	38件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, N ...	D09911	Gevokizumab	4件: 41, 50, 56, 269
7	IL6	45件: EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protei ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
8	IL6	45件: EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protei ...	D08976	Pomalidomide	5件: 28, 51, 85, 227, 331
9	IL6	45件: EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protei ...	D09669	Siltuximab	2件: 28, 331
10	IL6	45件: EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protei ...	D10080	Sirukumab	2件: 41, 46

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