Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	55件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	55件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	1件: 8
3	NQO1	6件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer, Che ...	D08682	Warfarin	11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
4	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D01977	Gefitinib	1件: 75
5	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D03455	Cetuximab	2件: 51, 86
6	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D07907	Erlotinib	1件: 94
7	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D08108	Lapatinib	3件: 34, 74, 75
8	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D08950	Neratinib	1件: 34
9	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D11251	Icotinib	1件: 34
10	EGFR	43件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D11772	Tesevatinib	1件: 67

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