Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adipocytokine signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
2 Adrenergic signaling in cardiomyocytes 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
3 Adrenergic signaling in cardiomyocytes 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
6 Alcoholic liver disease 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
7 Aldosterone synthesis and secretion 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
8 Aldosterone synthesis and secretion 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
9 Aldosterone-regulated sodium reabsorption 💬
1件: NR3C2 💬 D00443 💬 Spironolactone 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
10 AMPK signaling pathway 💬
1件: HMGCR 💬 D07983 💬 Fluvastatin 3件: 79, 218, 222 💬
11 AMPK signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
12 Apelin signaling pathway 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
13 Apelin signaling pathway 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
14 Apelin signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
15 Autophagy - animal 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
16 Bile secretion 💬
1件: HMGCR 💬 D07983 💬 Fluvastatin 3件: 79, 218, 222 💬
17 Calcium signaling pathway 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
18 Calcium signaling pathway 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
19 cAMP signaling pathway 💬
1件: EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
20 cGMP-PKG signaling pathway 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
21 cGMP-PKG signaling pathway 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
22 Chagas disease 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
23 Chagas disease 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
24 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
25 Circadian rhythm 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
26 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
27 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
28 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
29 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
30 Cortisol synthesis and secretion 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
31 Cortisol synthesis and secretion 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
32 Cushing syndrome 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
33 Cushing syndrome 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
34 Diabetic cardiomyopathy 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
35 Diabetic cardiomyopathy 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
36 Diabetic cardiomyopathy 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
37 Diabetic cardiomyopathy 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
38 Endocrine and other factor-regulated calcium reabsorption 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
39 Fluid shear stress and atherosclerosis 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
40 FoxO signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
41 Glucagon signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
42 Hypertrophic cardiomyopathy 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
43 Hypertrophic cardiomyopathy 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
44 Hypertrophic cardiomyopathy 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
45 Insulin resistance 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
46 Insulin signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
47 Longevity regulating pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
48 Longevity regulating pathway - multiple species 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
49 Metabolic pathways 💬
1件: HMGCR 💬 D07983 💬 Fluvastatin 3件: 79, 218, 222 💬
50 Mineral absorption 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
51 mTOR signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
52 Neuroactive ligand-receptor interaction 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
53 Neuroactive ligand-receptor interaction 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
54 Non-alcoholic fatty liver disease 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
55 Oxytocin signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
56 Parathyroid hormone synthesis, secretion and action 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
57 Pathways in cancer 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
58 Pathways in cancer 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
59 Phospholipase D signaling pathway 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
60 Phospholipase D signaling pathway 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
61 PI3K-Akt signaling pathway 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
62 Renin secretion 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
63 Renin secretion 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
64 Renin secretion 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
65 Renin secretion 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
66 Renin-angiotensin system 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
67 Renin-angiotensin system 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
68 Renin-angiotensin system 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
69 Renin-angiotensin system 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
70 Terpenoid backbone biosynthesis 💬
1件: HMGCR 💬 D07983 💬 Fluvastatin 3件: 79, 218, 222 💬
71 Thermogenesis 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
72 Tight junction 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
73 Tuberculosis 💬
1件: VDR 💬 D00930 💬 Paricalcitol 5件: 19, 66, 218, 238, 298 💬
74 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
75 Vascular smooth muscle contraction 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬