Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adipocytokine signaling pathway 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
2 Adrenergic signaling in cardiomyocytes 💬
 5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
3 Adrenergic signaling in cardiomyocytes 💬
 2件: ADRB1, ADRB2 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
4 Alcoholic liver disease 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
5 Alzheimer disease 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
6 AMPK signaling pathway 💬
 1件: ADRA1A 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
7 Arachidonic acid metabolism 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
8 Bile secretion 💬
 1件: NR1H4 💬 D09360 💬 Obeticholic acid 3件: 93, 265, 296 💬
9 Bile secretion 💬
 1件: NR1H4 💬 D00734 💬 Ursodeoxycholic acid 14件:  6 ,  8 , 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
10 Bile secretion 💬
 2件: SLC10A1, SLC10A2 💬 D10951 💬 Maralixibat 3件: 296, 297, 338 💬
11 Bile secretion 💬
 1件: SLC10A2 💬 D11716 💬 Odevixibat 3件: 296, 297, 338 💬
12 C-type lectin receptor signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
13 Calcium signaling pathway 💬
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
14 Calcium signaling pathway 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
15 cAMP signaling pathway 💬
 2件: ADRB1, ADRB2 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
16 cAMP signaling pathway 💬
 2件: ADRB1, ADRB2 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
17 cAMP signaling pathway 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
18 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
19 cGMP-PKG signaling pathway 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
20 Chemical carcinogenesis - DNA adducts 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
21 Chemical carcinogenesis - reactive oxygen species 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
22 Chemical carcinogenesis - receptor activation 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
23 Chemical carcinogenesis - receptor activation 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
24 Chemical carcinogenesis - receptor activation 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
25 Cytokine-cytokine receptor interaction 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 35件:  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
26 Cytokine-cytokine receptor interaction 💬
 1件: TNFSF13B 💬 D03068 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
27 Diabetic cardiomyopathy 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
28 Dilated cardiomyopathy 💬
 1件: ADRB1 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
29 Dilated cardiomyopathy 💬
 1件: ADRB1 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
30 Fluid shear stress and atherosclerosis 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
31 GABAergic synapse 💬
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
32 Gap junction 💬
 1件: ADRB1 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
33 Gap junction 💬
 1件: ADRB1 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
34 Glucagon signaling pathway 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
35 Hematopoietic cell lineage 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 35件:  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
36 Hematopoietic cell lineage 💬
 1件: MS4A1 💬 D02994 💬 Rituximab 48件: 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
37 Hepatitis B 💬
 1件: SLC10A1 💬 D10951 💬 Maralixibat 3件: 296, 297, 338 💬
38 Hepatitis C 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
39 Hepatocellular carcinoma 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
40 Human cytomegalovirus infection 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
41 Human papillomavirus infection 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
42 IL-17 signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
43 Insulin resistance 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
44 Intestinal immune network for IgA production 💬
 1件: TNFSF13B 💬 D03068 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
45 JAK-STAT signaling pathway 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 35件:  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
46 Kaposi sarcoma-associated herpesvirus infection 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
47 Leishmaniasis 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
48 Metabolic pathways 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
49 MicroRNAs in cancer 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
50 Morphine addiction 💬
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
51 Neuroactive ligand-receptor interaction 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
52 Neuroactive ligand-receptor interaction 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
53 Neuroactive ligand-receptor interaction 💬
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
54 Neuroactive ligand-receptor interaction 💬
 1件: NR3C1 💬 D00292 💬 Dexamethasone 22件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬
55 Neuroactive ligand-receptor interaction 💬
 1件: NR3C1 💬 D00407 💬 Methylprednisolone 46件:  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
56 Neuroactive ligand-receptor interaction 💬
 1件: NR3C1 💬 D00472 💬 Prednisolone 42件:  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
57 NF-kappa B signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
58 NF-kappa B signaling pathway 💬
 1件: TNFSF13B 💬 D03068 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
59 Nicotine addiction 💬
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
60 Non-alcoholic fatty liver disease 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
61 Ovarian steroidogenesis 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
62 Oxytocin signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
63 Parkinson disease 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
64 Pathways in cancer 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 35件:  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
65 Pathways in cancer 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
66 Pathways in cancer 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
67 Pathways of neurodegeneration - multiple diseases 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
68 PI3K-Akt signaling pathway 💬
 1件: CSF3R 💬 D03235 💬 Filgrastim 35件:  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
69 PPAR signaling pathway 💬
 1件: PPARA 💬 D01366 💬 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324 💬
70 Regulation of lipolysis in adipocytes 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
71 Regulation of lipolysis in adipocytes 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
72 Regulation of lipolysis in adipocytes 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
73 Renin secretion 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
74 Renin secretion 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
75 Retrograde endocannabinoid signaling 💬
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
76 Retrograde endocannabinoid signaling 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
77 Rheumatoid arthritis 💬
 1件: TNFSF13B 💬 D03068 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
78 Salivary secretion 💬
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
79 Salivary secretion 💬
 3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
80 Serotonergic synapse 💬
 3件: GABRB1, GABRB2, GABRB3 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
81 Serotonergic synapse 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
82 Small cell lung cancer 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
83 Taste transduction 💬
 6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00549 💬 Propofol 9件:  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
84 Thermogenesis 💬
 1件: ADRB3 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
85 Thermogenesis 💬
 1件: ADRB3 💬 D08443 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
86 TNF signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
87 Ubiquitin mediated proteolysis 💬
 1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
88 Vascular smooth muscle contraction 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 D00076 💬 Norepinephrine 2件: 22, 296 💬
89 VEGF signaling pathway 💬
 1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬

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