Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D10893 D10893 💬 |
Acalabrutinib | 046 2件: 46, 61 💬 |
2 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D11478 D11478 💬 |
Branebrutinib | 046 3件: 46, 49, 53 💬 |
3 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D12467 D12467 💬 |
Evobrutinib | 013 3件: 13, 46, 49 💬 |
4 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D11457 D11457 💬 |
Fenebrutinib | 013 1件: 13 💬 |
5 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D10223 D10223 💬 |
Ibrutinib | 028 3件: 28, 60, 61 💬 |
6 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D12160 D12160 💬 |
Orelabrutinib | 013 4件: 13, 49, 61, 63 💬 |
7 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D12285 D12285 💬 |
Remibrutinib | 013 2件: 13, 53 💬 |
8 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
BTK 1件: BTK 💬 |
D11422 D11422 💬 |
Zanubrutinib | 013 5件: 13, 63, 222, 300, 331 💬 |
9 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
CD19 1件: CD19 💬 |
D11757 D11757 💬 |
Inebilizumab | 011 4件: 11, 13, 51, 300 💬 |
10 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
CD19 1件: CD19 💬 |
D11496 D11496 💬 |
Obexelimab | 300 1件: 300 💬 |
11 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
CD22 1件: CD22 💬 |
D04036 D04036 💬 |
Epratuzumab | 049 1件: 49 💬 |
12 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
LILRA4 1件: LILRA4 💬 |
D11778 D11778 💬 |
Daxdilimab | 049 2件: 49, 50 💬 |
13 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
14 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
15 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
16 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
17 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
18 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
NFKB1 1件: NFKB1 💬 |
D01146 D01146 💬 |
Iguratimod | 046 5件: 46, 51, 53, 271, 300 💬 |
19 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PIK3CA 1件: PIK3CA 💬 |
D11011 D11011 💬 |
Alpelisib | 138 1件: 138 💬 |
20 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
21 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
22 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PPP3CA 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
23 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PPP3CA 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D05480 D05480 💬 |
Pimecrolimus | 160 1件: 160 💬 |
24 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PPP3CA 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00107 D00107 💬 |
Tacrolimus | 002 34件: 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 |
25 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PPP3CA 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D08556 D08556 💬 |
Tacrolimus | 002 34件: 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 |
26 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PPP3CA 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D09033 D09033 💬 |
Voclosporin | 049 2件: 49, 222 💬 |
27 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
PRKCB 1件: PRKCB 💬 |
D11935 D11935 💬 |
Enzastaurin | 168 1件: 168 💬 |
28 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
RAF1 1件: RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
29 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
RELA 1件: RELA 💬 |
D12181 D12181 💬 |
Edasalonexent | 113 1件: 113 💬 |
30 | B cell receptor signaling pathway 💬 Related to 19 target genes, 29 drugs (DrugBank) and 68 diseases in DDrare |
SYK 1件: SYK 💬 |
D09347 D09347 💬 |
Fostamatinib | 046 4件: 46, 49, 61, 66 💬 |
31 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
MET 1件: MET 💬 |
D10062 D10062 💬 |
Cabozantinib | 034 1件: 34 💬 |
32 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
PIK3CA 1件: PIK3CA 💬 |
D11011 D11011 💬 |
Alpelisib | 138 1件: 138 💬 |
33 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
34 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
35 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
SRC 1件: SRC 💬 |
D03252 D03252 💬 |
Bosutinib | 002 2件: 2 , 67 💬 |
36 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
SRC 1件: SRC 💬 |
D03658 D03658 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
37 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
SRC 1件: SRC 💬 |
D06414 D06414 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
38 | Bacterial invasion of epithelial cells 💬 Related to 5 target genes, 7 drugs (DrugBank) and 13 diseases in DDrare |
SRC 1件: SRC 💬 |
D09664 D09664 💬 |
Saracatinib | 006 3件: 6 , 89, 272 💬 |
39 | Basal cell carcinoma 💬 Related to 1 target gene, 2 drugs (DrugBank) and 1 disease in DDrare |
SMO 1件: SMO 💬 |
D10671 D10671 💬 |
Taladegib | 085 1件: 85 💬 |
40 | Basal cell carcinoma 💬 Related to 1 target gene, 2 drugs (DrugBank) and 1 disease in DDrare |
SMO 1件: SMO 💬 |
D09992 D09992 💬 |
Vismodegib | 085 1件: 85 💬 |
41 | Base excision repair 💬 Related to 2 target genes, 1 drug (DrugBank) and 2 diseases in DDrare |
PARP1 2件: PARP1, PARP2 💬 |
D09730 D09730 💬 |
Olaparib | 086 2件: 86, 285 💬 |
42 | beta-Alanine metabolism 💬 Related to 4 target genes, 3 drugs (DrugBank) and 17 diseases in DDrare |
ABAT 1件: ABAT 💬 |
D00535 D00535 💬 |
Vigabatrin | 145 2件: 145, 158 💬 |
43 | beta-Alanine metabolism 💬 Related to 4 target genes, 3 drugs (DrugBank) and 17 diseases in DDrare |
ABAT 3件: ABAT, GAD1, GAD2 💬 |
D00399 D00399 💬 |
Valproic acid | 002 14件: 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 |
44 | beta-Alanine metabolism 💬 Related to 4 target genes, 3 drugs (DrugBank) and 17 diseases in DDrare |
AOC3 1件: AOC3 💬 |
D08044 D08044 💬 |
Hydralazine | 067 1件: 67 💬 |
45 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
ATP1A1 4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
D00297 D00297 💬 |
Digitoxin | 299 1件: 299 💬 |
46 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
ATP1A1 4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
D00298 D00298 💬 |
Digoxin | 008 3件: 8 , 46, 210 💬 |
47 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CA2 1件: CA2 💬 |
D00218 D00218 💬 |
Acetazolamide | 013 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬 |
48 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CA2 1件: CA2 💬 |
D00518 D00518 💬 |
Diclofenamide | 114 1件: 114 💬 |
49 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CA2 1件: CA2 💬 |
D07871 D07871 💬 |
Dorzolamide | 090 1件: 90 💬 |
50 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CA2 1件: CA2 💬 |
D00537 D00537 💬 |
Topiramate | 006 6件: 6 , 97, 140, 144, 156, 193 💬 |
51 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D11423 D11423 💬 |
Deutivacaftor | 299 1件: 299 💬 |
52 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D11507 D11507 💬 |
Elexacaftor | 299 1件: 299 💬 |
53 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D11724 D11724 💬 |
Galicaftor | 299 1件: 299 💬 |
54 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D09916 D09916 💬 |
Ivacaftor | 299 1件: 299 💬 |
55 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D10134 D10134 💬 |
Lumacaftor | 299 1件: 299 💬 |
56 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
CFTR 1件: CFTR 💬 |
D11041 D11041 💬 |
Tezacaftor | 299 1件: 299 💬 |
57 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D07474 D07474 💬 |
Atorvastatin | 013 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 |
58 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D07983 D07983 💬 |
Fluvastatin | 079 3件: 79, 218, 222 💬 |
59 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D00359 D00359 💬 |
Lovastatin | 006 11件: 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 |
60 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D08410 D08410 💬 |
Pravastatin | 013 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬 |
61 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D08492 D08492 💬 |
Rosuvastatin | 006 11件: 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 |
62 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
HMGCR 1件: HMGCR 💬 |
D00434 D00434 💬 |
Simvastatin | 006 21件: 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 |
63 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
NR1H4 1件: NR1H4 💬 |
D00163 D00163 💬 |
Chenodeoxycholic acid | 020 4件: 20, 96, 234, 263 💬 |
64 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
NR1H4 1件: NR1H4 💬 |
D10699 D10699 💬 |
Cholic Acid | 020 4件: 20, 234, 265, 310 💬 |
65 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
NR1H4 1件: NR1H4 💬 |
D09360 D09360 💬 |
Obeticholic acid | 093 3件: 93, 265, 296 💬 |
66 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
NR1H4 1件: NR1H4 💬 |
D11548 D11548 💬 |
Tropifexor | 093 1件: 93 💬 |
67 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
NR1H4 1件: NR1H4 💬 |
D00734 D00734 💬 |
Ursodeoxycholic acid | 006 14件: 6 , 8 , 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬 |
68 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
RXRA 1件: RXRA 💬 |
D02754 D02754 💬 |
Acitretin | 037 1件: 37 💬 |
69 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
RXRA 1件: RXRA 💬 |
D02815 D02815 💬 |
Alitretinoin | 049 1件: 49 💬 |
70 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
RXRA 1件: RXRA 💬 |
D03106 D03106 💬 |
Bexarotene | 013 2件: 13, 75 💬 |
71 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
SLC10A1 2件: SLC10A1, SLC10A2 💬 |
D10951 D10951 💬 |
Maralixibat | 296 3件: 296, 297, 338 💬 |
72 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
SLC10A2 1件: SLC10A2 💬 |
D10796 D10796 💬 |
Elobixibat | 006 1件: 6 💬 |
73 | Bile secretion 💬 Related to 11 target genes, 29 drugs (DrugBank) and 60 diseases in DDrare |
SLC10A2 1件: SLC10A2 💬 |
D11716 D11716 💬 |
Odevixibat | 296 3件: 296, 297, 338 💬 |
74 | Biosynthesis of amino acids 💬 Related to 2 target genes, 2 drugs (DrugBank) and 4 diseases in DDrare |
CPS1 1件: CPS1 💬 |
D07130 D07130 💬 |
Carglumic acid | 245 3件: 245, 246, 251 💬 |
75 | Biosynthesis of amino acids 💬 Related to 2 target genes, 2 drugs (DrugBank) and 4 diseases in DDrare |
PAH 1件: PAH 💬 |
D11077 D11077 💬 |
Pegvaliase | 240 1件: 240 💬 |
76 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
ALAS1 1件: ALAS1 💬 |
D11702 D11702 💬 |
Givosiran | 254 1件: 254 💬 |
77 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
ALAS1 2件: ALAS1, ALAS2 💬 |
D10003 D10003 💬 |
Hemin | 254 1件: 254 💬 |
78 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
ALPL 1件: ALPL 💬 |
D10595 D10595 💬 |
Asfotase alfa | 172 1件: 172 💬 |
79 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
DHFR 2件: DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 |
80 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
DHODH 1件: DHODH 💬 |
D00749 D00749 💬 |
Leflunomide | 011 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬 |
81 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
DHODH 1件: DHODH 💬 |
D10172 D10172 💬 |
Teriflunomide | 013 3件: 13, 25, 26 💬 |
82 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
GUSB 1件: GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 1件: 19 💬 |
83 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
HPD 1件: HPD 💬 |
D05177 D05177 💬 |
Nitisinone | 006 3件: 6 , 164, 241 💬 |
84 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
NQO1 2件: NQO1, VKORC1 💬 |
D08682 D08682 💬 |
Warfarin | 006 11件: 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬 |
85 | Biosynthesis of cofactors 💬 Related to 10 target genes, 10 drugs (DrugBank) and 51 diseases in DDrare |
VKORC1 1件: VKORC1 💬 |
D08354 D08354 💬 |
Phenindione | 065 1件: 65 💬 |
86 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
BRAF 1件: BRAF 💬 |
D10064 D10064 💬 |
Dabrafenib | 034 1件: 34 💬 |
87 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
BRAF 2件: BRAF, RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
88 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
CDK4 1件: CDK4 💬 |
D10688 D10688 💬 |
Abemaciclib | 034 1件: 34 💬 |
89 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D03455 D03455 💬 |
Cetuximab | 051 2件: 51, 86 💬 |
90 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D07907 D07907 💬 |
Erlotinib | 094 1件: 94 💬 |
91 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D01977 D01977 💬 |
Gefitinib | 075 1件: 75 💬 |
92 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D11251 D11251 💬 |
Icotinib | 034 1件: 34 💬 |
93 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 2件: EGFR, ERBB2 💬 |
D08108 D08108 💬 |
Lapatinib | 034 3件: 34, 74, 75 💬 |
94 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 2件: EGFR, ERBB2 💬 |
D08950 D08950 💬 |
Neratinib | 034 1件: 34 💬 |
95 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
EGFR 2件: EGFR, ERBB2 💬 |
D11772 D11772 💬 |
Tesevatinib | 067 1件: 67 💬 |
96 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
FGFR3 1件: FGFR3 💬 |
D11589 D11589 💬 |
Infigratinib | 276 1件: 276 💬 |
97 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
FGFR3 1件: FGFR3 💬 |
D10481 D10481 💬 |
Nintedanib | 051 5件: 51, 85, 89, 227, 228 💬 |
98 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
99 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
100 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
101 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
102 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
103 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
SRC 1件: SRC 💬 |
D03252 D03252 💬 |
Bosutinib | 002 2件: 2 , 67 💬 |
104 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
SRC 1件: SRC 💬 |
D03658 D03658 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
105 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
SRC 1件: SRC 💬 |
D06414 D06414 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
106 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
SRC 1件: SRC 💬 |
D09664 D09664 💬 |
Saracatinib | 006 3件: 6 , 89, 272 💬 |
107 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
VEGFA 1件: VEGFA 💬 |
D09574 D09574 💬 |
Aflibercept | 090 2件: 90, 166 💬 |
108 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
VEGFA 1件: VEGFA 💬 |
D06409 D06409 💬 |
Bevacizumab | 013 6件: 13, 34, 85, 87, 227, 280 💬 |
109 | Bladder cancer 💬 Related to 10 target genes, 23 drugs (DrugBank) and 22 diseases in DDrare |
VEGFA 1件: VEGFA 💬 |
D05697 D05697 💬 |
Ranibizumab | 034 4件: 34, 166, 227, 301 💬 |
110 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
BRAF 1件: BRAF 💬 |
D10064 D10064 💬 |
Dabrafenib | 034 1件: 34 💬 |
111 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
BRAF 4件: BRAF, FLT4, KIT, RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
112 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
CDK4 2件: CDK4, CDK6 💬 |
D10688 D10688 💬 |
Abemaciclib | 034 1件: 34 💬 |
113 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D03455 D03455 💬 |
Cetuximab | 051 2件: 51, 86 💬 |
114 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D07907 D07907 💬 |
Erlotinib | 094 1件: 94 💬 |
115 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D01977 D01977 💬 |
Gefitinib | 075 1件: 75 💬 |
116 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 1件: EGFR 💬 |
D11251 D11251 💬 |
Icotinib | 034 1件: 34 💬 |
117 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 2件: EGFR, ERBB2 💬 |
D08108 D08108 💬 |
Lapatinib | 034 3件: 34, 74, 75 💬 |
118 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 2件: EGFR, ERBB2 💬 |
D08950 D08950 💬 |
Neratinib | 034 1件: 34 💬 |
119 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
EGFR 3件: EGFR, ERBB2, FLT4 💬 |
D11772 D11772 💬 |
Tesevatinib | 067 1件: 67 💬 |
120 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 1件: ESR1 💬 |
D00554 D00554 💬 |
Ethinylestradiol | 013 4件: 13, 46, 49, 299 💬 |
121 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D07726 D07726 💬 |
Clomifene | 074 1件: 74 💬 |
122 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D11513 D11513 💬 |
Estetrol | 053 1件: 53 💬 |
123 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D11514 D11514 💬 |
Estetrol | 053 1件: 53 💬 |
124 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00105 D00105 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
125 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01413 D01413 💬 |
Estradiol valerate | 065 1件: 65 💬 |
126 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00185 D00185 💬 |
Estriol | 013 2件: 13, 227 💬 |
127 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01986 D01986 💬 |
Estriol | 013 2件: 13, 227 💬 |
128 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01161 D01161 💬 |
Fulvestrant | 049 2件: 49, 86 💬 |
129 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00575 D00575 💬 |
Mestranol | 046 2件: 46, 49 💬 |
130 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08409 D08409 💬 |
Prasterone | 049 6件: 49, 53, 83, 86, 96, 113 💬 |
131 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08465 D08465 💬 |
Raloxifene | 046 1件: 46 💬 |
132 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08559 D08559 💬 |
Tamoxifen | 002 3件: 2 , 113, 227 💬 |
133 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, PGR 💬 |
D00289 D00289 💬 |
Danazol | 060 5件: 60, 63, 64, 65, 285 💬 |
134 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
ESR1 2件: ESR1, PGR 💬 |
D02367 D02367 💬 |
Desogestrel | 230 1件: 230 💬 |
135 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FGF23 1件: FGF23 💬 |
D10913 D10913 💬 |
Burosumab | 238 1件: 238 💬 |
136 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FGFR1 1件: FGFR1 💬 |
D11589 D11589 💬 |
Infigratinib | 276 1件: 276 💬 |
137 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FGFR1 2件: FGFR1, FLT4 💬 |
D10481 D10481 💬 |
Nintedanib | 051 5件: 51, 85, 89, 227, 228 💬 |
138 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FLT4 1件: FLT4 💬 |
D03218 D03218 💬 |
Axitinib | 034 1件: 34 💬 |
139 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FLT4 1件: FLT4 💬 |
D08881 D08881 💬 |
Cediranib | 034 1件: 34 💬 |
140 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
FLT4 2件: FLT4, KIT 💬 |
D08552 D08552 💬 |
Sunitinib | 028 2件: 28, 34 💬 |
141 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09925 D09925 💬 |
Linsitinib | 232 1件: 232 💬 |
142 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D03297 D03297 💬 |
Mecasermin | 065 6件: 65, 78, 96, 168, 265, 299 💬 |
143 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
IGF1R 1件: IGF1R 💬 |
D09680 D09680 💬 |
Teprotumumab | 051 1件: 51 💬 |
144 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D03658 D03658 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
145 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D06414 D06414 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
146 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D08066 D08066 💬 |
Imatinib | 013 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 |
147 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D10229 D10229 💬 |
Masitinib | 002 6件: 2 , 5 , 6 , 13, 46, 96 💬 |
148 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D08953 D08953 💬 |
Nilotinib | 006 5件: 6 , 8 , 34, 51, 86 💬 |
149 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
KIT 1件: KIT 💬 |
D11270 D11270 💬 |
Pexidartinib | 034 1件: 34 💬 |
150 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
151 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
152 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D11675 D11675 💬 |
Mirdametinib | 034 1件: 34 💬 |
153 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
154 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
155 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D02714 D02714 💬 |
Everolimus | 034 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 |
156 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 40件: 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 |
157 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
MTOR 1件: MTOR 💬 |
D06068 D06068 💬 |
Temsirolimus | 013 1件: 13 💬 |
158 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D01217 D01217 💬 |
Dydrogesterone | 013 1件: 13 💬 |
159 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00950 D00950 💬 |
Levonorgestrel | 013 1件: 13 💬 |
160 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00951 D00951 💬 |
Medroxyprogesterone acetate | 013 8件: 13, 35, 46, 49, 50, 51, 60, 107 💬 |
161 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00952 D00952 💬 |
Megestrol acetate | 076 1件: 76 💬 |
162 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00585 D00585 💬 |
Mifepristone | 075 1件: 75 💬 |
163 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D07222 D07222 💬 |
Nomegestrol | 013 1件: 13 💬 |
164 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D08281 D08281 💬 |
Nomegestrol acetate | 013 1件: 13 💬 |
165 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00182 D00182 💬 |
Norethisterone | 013 4件: 13, 46, 49, 299 💬 |
166 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D05209 D05209 💬 |
Norgestimate | 299 1件: 299 💬 |
167 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D00066 D00066 💬 |
Progesterone | 076 2件: 76, 299 💬 |
168 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PGR 1件: PGR 💬 |
D09567 D09567 💬 |
Ulipristal | 010 1件: 10 💬 |
169 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PIK3CA 1件: PIK3CA 💬 |
D11011 D11011 💬 |
Alpelisib | 138 1件: 138 💬 |
170 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
171 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
172 | Breast cancer 💬 Related to 21 target genes, 60 drugs (DrugBank) and 74 diseases in DDrare |
TNFSF11 1件: TNFSF11 💬 |
D03684 D03684 💬 |
Denosumab | 046 8件: 46, 50, 70, 93, 95, 96, 274, 299 💬 |
173 | Butanoate metabolism 💬 Related to 4 target genes, 2 drugs (DrugBank) and 16 diseases in DDrare |
ABAT 1件: ABAT 💬 |
D00535 D00535 💬 |
Vigabatrin | 145 2件: 145, 158 💬 |
174 | Butanoate metabolism 💬 Related to 4 target genes, 2 drugs (DrugBank) and 16 diseases in DDrare |
ABAT 4件: ABAT, ALDH5A1, GAD1, GAD2 💬 |
D00399 D00399 💬 |
Valproic acid | 002 14件: 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 |