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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1.Nusinersen[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
20000----[1] 3
32011-2012 seasonal flu vaccine Intramuscular----[2] 3, 113
42011-2012 seasonal flu vaccine Subcutaneous----[2] 3, 113
53,4-Diaminopyridine Phosphate[1] Phosphate ion---[1] 3
64-Aminopyridine[1] Dalfampridine[1] D04127 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[2] 3, 13
74-cholesten-3-one, oxime----[2] 2, 3
84-cholesten-3-one,oxime----[1] 3
9Adipose derived mesenchymal stem cell----[1] 3
10AMIFAMPRIDINA----[2] 3, 11
11Amifampridina fosfato----[2] 3, 11
12Amifampridine[1] Amifampridine[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[3] 3, 11, 12
13Amifampridine Phosphate[2] Amifampridine,
Phosphate ion		[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[3] 3, 11, 12
14Amifampridine Phosphate 10 MG Oral Tablet[2] Amifampridine,
Phosphate ion		[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[1] 3
15Apitegromab[1] Apitegromab[1] D11797 [1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 3
16AVXS-101----[1] 3
17AVXS-101 (previously known as scAAV9.CB.SMN)----[1] 3
18Biocarn----[1] 3
19Branaplam[1] Branaplam[1] D12272 [1] SMN2 💬-[2] 3, 8
20Celecoxib[1] Celecoxib[1] D00567 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
21Disease modifying treatments----[1] 3
22EVRYSDI[1] Risdiplam[1] D11406 [1] SMN2 💬[1] Nucleocytoplasmic transport 💬[1] 3
23EXG001-307 injection----[1] 3
24Firdapse[1] Amifampridine[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[2] 3, 11
25FIRDAPSE - 10 MG - COMPRESSE - USO ORALE - BLISTER(ALU/PVC/PVDC) 100 X 1 COMPRESSE[1] Amifampridine[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[2] 3, 11
26GH----[1] 3
27GYM329----[1] 3
28HUMAN ANTI-PROMYOSTATIN MONOCLONAL ANTIBODY----[1] 3
29Hydroxyurea[1] Hydroxyurea[1] D00341 [1] RRM2 💬[7] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[8] 3, 13, 19, 20, 65, 85, 86, 284
30ISIS 396443----[1] 3
31ISIS 396443 (BIIB058)----[1] 3
32ISIS 396443, BIIB058----[1] 3
33Itraconazole[1] Itraconazole[1] D00350 --[6] 3, 46, 65, 96, 227, 299
34Leuprolide[1] Leuprolide---[5] 1, 2, 3, 51, 76
35LEVOCARNITINE[1] Levocarnitine[1] D02176 --[3] 3, 53, 97
36LMI070----[2] 3, 8
37Mestinon[1] Pyridostigmine---[3] 3, 6, 11
38Midazolam[1] Midazolam[1] D00550 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299
39N.a.----[10] 3, 6, 8, 13, 46, 96, 97, 240, 256, 271
40Nerve Growth Factor[1] Nerve Growth Factor---[3] 3, 53, 90
41Norditropin SimpleXx----[5] 3, 78, 107, 193, 195
42Norditropin SimpleXx 15 mg/1.5 ml[1] Somatotropin---[1] 3
43Nursinersen----[1] 3
44NUSINERSEN[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
45Nusinersen Injectable Product[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
46NUSINERSEN SODIUM[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
47Nusinersen Treatments[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
48OAV101----[1] 3
49Okrido----[1] 3
50Okrido 6mg/mL oral solution----[1] 3
51Olesoxime[1] Olesoxime[1] D11213 --[3] 2, 3, 13
52ONASEMNOGENE ABEPARVOVEC[1] Onasemnogene abeparvovec[1] D11559 [1] SMN1 💬-[1] 3
53Onasemnogene Abeparvovec-xioi[1] Onasemnogene abeparvovec[1] D11559 [1] SMN1 💬-[1] 3
54Orfiril Saft----[1] 3
55PARACETAMOL[1] Acetaminophen[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[6] 3, 6, 13, 35, 46, 49
56Paracetamol 120Mg/5mL Oral Suspension[1] Acetaminophen[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 3
57PHENYLBUTYRATE[1] Phenylbutyric acid---[12] 2, 3, 6, 8, 15, 93, 94, 244, 251, 297, 299, 338
58Phosphate[1] Phosphate ion---[32] 2, 3, 6, 11, 12, 13, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
59Placebo----[28] 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
60PREDNISOLONE[1] Prednisolone[1] D00472 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300
61PREDNISOLONE SODIUM PHOSPHATE[2] Phosphate ion,
Prednisolone		[1] D00472 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 3, 13, 97
62Previously termed sc.AAV9.CB.SMN and AVXS-101----[1] 3
63Pyridostigmine[1] Pyridostigmine---[4] 3, 6, 11, 256
64Pyridostigmine Bromide[1] Pyridostigmine---[3] 3, 6, 256
65RELDESEMTIV[1] Reldesemtiv[1] D11363 [1] TNNC2 💬[1] Calcium signaling pathway 💬[2] 2, 3
66Reldesemtiv 150 mg[1] Reldesemtiv[1] D11363 [1] TNNC2 💬[1] Calcium signaling pathway 💬[1] 3
67Reldesemtiv 450 mg[1] Reldesemtiv[1] D11363 [1] TNNC2 💬[1] Calcium signaling pathway 💬[1] 3
68RILUZOLE[1] Riluzole[1] D00775 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[9] 2, 3, 5, 8, 13, 17, 18, 203, 206
69Risdiplam[1] Risdiplam[1] D11406 [1] SMN2 💬[1] Nucleocytoplasmic transport 💬[1] 3
70RO6885247----[1] 3
71RO6885247/F02----[1] 3
72RO6885247/F03----[1] 3
73RO7034067----[1] 3
74RO7034067 / F12----[1] 3
75RO7034067 / F13----[1] 3
76RO7034067/F06 + solvente (RO----[1] 3
77RO7034067/F06 with solvent (RO7034067/F08)----[1] 3
78RO7034067/F07 + solvente (RO----[1] 3
79RO7034067/F07 with solvent (RO7034067/F09)----[1] 3
80RO7034067/F12----[1] 3
81RO7034067/F13----[1] 3
82RO7090919----[1] 3
83RO7204239----[2] 3, 113
84RO7204239/F01-01----[1] 3
85RVG 03820----[1] 3
86Salbutamol[1] Salbutamol[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 3, 11, 49, 85, 86, 111, 256, 299
87Sesame oil[1] Sesame oil[1] D03314 --[1] 3
88SESAME OIL, REFINED[1] Sesame oil[1] D03314 --[1] 3
89SMART----[1] 3
90Sodium phenylbutyrate[1] Phenylbutyric acid---[4] 2, 3, 8, 251
91Sodium phenylbutyrate (NaPB)[1] Phenylbutyric acid---[1] 3
92Somatotropin[1] Somatotropin---[4] 3, 65, 78, 236
93Somatropin[1] Somatotropin---[19] 2, 3, 19, 46, 65, 74, 75, 78, 96, 107, 113, 187, 193, 195, 238, 265, 274, 276, 299
94Spinraza[1] Nusinersen[1] D10881 [1] SMN2 💬-[1] 3
95SRK-015----[1] 3
96Sulfate[1] Sulfate ion---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299
97Survival of Motor Neuron 2 (SMN2) Splicing Modulator Antisense Oligonucleotide----[1] 3
98Taldefgrobep alfa[1] Talditercept alfa[1] D11265 [1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 3
99Testosterone[1] Testosterone[1] D00075 [1] AR 💬[4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[8] 1, 2, 3, 13, 60, 76, 78, 113
100TRO19622----[2] 2, 3
101Valproate[1] Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[6] 2, 3, 90, 102, 233, 256
102VALPROATE SODIUM[1] Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[1] 3
103Valproate, Levocarnitine[2] Levocarnitine,
Valproic acid		[2] D00399 ,
D02176 		[7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[1] 3
104Valproic Acid[1] Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[7] 3, 5, 26, 65, 90, 222, 256
105Valproic Acid (VPA)[1] Valproic acid[1] D00399 [7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[1] 3
106Valproic Acid and Levocarnitine[2] Levocarnitine,
Valproic acid		[2] D00399 ,
D02176 		[7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		[17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[1] 3
107VOLMAX*30CPR 4MG R.P.----[1] 3
108VPA----[1] 3
109Zolgensma[1] Onasemnogene abeparvovec[1] D11559 [1] SMN1 💬-[1] 3
110Zolgensma 2 x 1013 vector genomes/mL solution for infusion[1] Onasemnogene abeparvovec[1] D11559 [1] SMN1 💬-[1] 3
111Zolgensma 2 x 1013 vg (vector genomes)/mL solution for infusion[1] Onasemnogene abeparvovec[1] D11559 [1] SMN1 💬-[1] 3