Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	GABBR1	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transd ...	D00241	Baclofen	[8] 2, 10, 13, 18, 65, 70, 149, 206
2	OPRD1	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interact ...	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
3	OPRK1	[1] Neuroactive ligand-receptor interaction	D05113	Naltrexone	[12] 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
4	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D05113	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
5	PGR	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical ca ...	D09567	Ulipristal	[1] 10
6	SCN1A	[1] Dopaminergic synapse	D08215	Mexiletine	[3] 10, 113, 114
7	SCN2A	[1] Taste transduction	D08215	Mexiletine	[3] 10, 113, 114
8	SCN3A	[1] Taste transduction	D08215	Mexiletine	[3] 10, 113, 114
9	SCN5A	[1] Adrenergic signaling in cardiomyocytes	D08215	Mexiletine	[3] 10, 113, 114
10	SCN9A	[1] Taste transduction	D08215	Mexiletine	[3] 10, 113, 114

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