Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D03742	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2	TUBB3	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
3	TUBB4A	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
4	TUBB4B	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
5	CYSLTR1	[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction	D01385	Ibudilast	[2] 2, 13
6	CHRM1	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00113	Atropine	[2] 2, 299
7	CHRM1	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00138	Scopolamine	[1] 2
8	CHRM2	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00113	Atropine	[2] 2, 299
9	CHRM2	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00138	Scopolamine	[1] 2
10	CHRM3	[11] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste ...	D00113	Atropine	[2] 2, 299

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