Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D03742	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2	CYSLTR1	[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction	D08229	Montelukast	[8] 6, 13, 46, 61, 63, 85, 98, 228
3	HRH3	[1] Neuroactive ligand-receptor interaction	D09870	Bavisant	[1] 6
4	HRH3	[1] Neuroactive ligand-receptor interaction	D10749	Pitolisant	[3] 6, 113, 193
5	CHRM1	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00397	Tropicamide	[1] 6
6	CHRM1	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00465	Oxybutynin	[3] 6, 13, 53
7	CHRM1	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D08638	Trihexyphenidyl	[2] 5, 6
8	CHRM2	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00397	Tropicamide	[1] 6
9	CHRM2	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00465	Oxybutynin	[3] 6, 13, 53
10	CHRM2	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K ...	D00525	Pilocarpine	[3] 6, 53, 299

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