Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	IL1B	[24] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, ...	D01583	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
2	IL1B	[24] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, ...	D06635	Rilonacept	[4] 51, 106, 107, 266
3	IL1B	[24] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, ...	D09315	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
4	IL1B	[24] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, ...	D09911	Gevokizumab	[4] 41, 50, 56, 269
5	IL6	[21] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D01583	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
6	IL6	[21] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D08976	Pomalidomide	[5] 28, 51, 85, 227, 331
7	IL6	[21] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D09669	Siltuximab	[2] 28, 331
8	IL6	[21] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D10080	Sirukumab	[2] 41, 46
9	IL6	[21] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D12487	Olokizumab	[2] 46, 96
10	IL12A	[13] Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell d ...	D09214	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271

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