Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	PARP2	[2] Base excision repair, Apoptosis	D09730	Olaparib	[2] 86, 285
2	PDE10A	[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction	D00227	Aminophylline	[1] 63
3	PDE10A	[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction	D00371	Theophylline	[2] 236, 299
4	PDE10A	[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction	D06103	Theophylline	[2] 236, 299
5	PDE10A	[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction	D07546	Bucladesine	[1] 246
6	PDE10A	[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction	D07961	Flavoxate	[1] 226
7	PARP1	[5] Base excision repair, NF-kappa B signaling pathway, Apoptosis, Necroptosis, Diabetic cardiomyopa ...	D09730	Olaparib	[2] 86, 285
8	POLA2	[1] DNA replication	D03546	Clofarabine	[5] 19, 20, 60, 234, 326
9	PCSK9	[1] Cholesterol metabolism	D10335	Alirocumab	[1] 79
10	PCSK9	[1] Cholesterol metabolism	D10557	Evolocumab	[2] 79, 222

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