Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	RGMA	[2] TGF-beta signaling pathway, Axon guidance	D11355	Elezanumab	[1] 13
2	RTN4	[1] Alzheimer disease	D10331	Ozanezumab	[1] 2
3	RAF1	[83] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D08524	Sorafenib	[2] 34, 86
4	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D00094	Tretinoin	[6] 2, 62, 63, 75, 94, 231
5	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D00348	Isotretinoin	[4] 36, 39, 159, 160
6	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D01418	Tamibarotene	[2] 26, 96
7	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D02754	Acitretin	[1] 37
8	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D02815	Alitretinoin	[1] 49
9	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D04162	Fenretinide	[1] 299
10	RARA	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misre ...	D06543	Vitamin A	[3] 13, 53, 90

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