Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2A 💬	D00528 💬	Caffeine	[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬
2	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2A 💬	D01453 💬	Caffeine	[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬
3	Neuroactive ligand-receptor interaction 💬	[4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬	D00045 💬	Adenosine	[3] 13, 58, 65 💬
4	Neuroactive ligand-receptor interaction 💬	[4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬	D02769 💬	Adenosine phosphate	[1] 46 💬
5	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D00227 💬	Aminophylline	[1] 63 💬
6	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
7	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
8	Neuroactive ligand-receptor interaction 💬	[1] ADORA2A 💬	D04641 💬	Istradefylline	[1] 6 💬
9	Neuroactive ligand-receptor interaction 💬	[1] ADORA2A 💬	D09717 💬	Preladenant	[1] 6 💬
10	Neuroactive ligand-receptor interaction 💬	[1] ADORA2A 💬	D05711 💬	Regadenoson	[1] 58 💬

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