Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Tight junction 💬
[1] CACNA1D 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
2 Tight junction 💬
[1] CACNA1D 💬 D01173 💬 Cilnidipine [1] 67 💬
3 Tight junction 💬
[1] CACNA1D 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
4 Tight junction 💬
[1] CACNA1D 💬 D00349 💬 Isradipine [1]  6  💬
5 Tight junction 💬
[1] CACNA1D 💬 D08270 💬 Nicardipine [2] 70, 86 💬
6 Tight junction 💬
[1] CACNA1D 💬 D00437 💬 Nifedipine [2] 50, 81 💬
7 Tight junction 💬
[1] CACNA1D 💬 D01908 💬 Nilvadipine [1] 90 💬
8 Tight junction 💬
[1] CACNA1D 💬 D08340 💬 Perhexiline [2] 58, 272 💬
9 Tight junction 💬
[1] CACNA1D 💬 D08441 💬 Propiverine [1] 226 💬
10 Tight junction 💬
[1] CACNA1D 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
11 Tight junction 💬
[1] CACNA1D 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
12 Tight junction 💬
[1] CDK4 💬 D10688 💬 Abemaciclib [1] 34 💬
13 Tight junction 💬
[1] CFTR 💬 D11423 💬 Deutivacaftor [1] 299 💬
14 Tight junction 💬
[1] CFTR 💬 D11507 💬 Elexacaftor [1] 299 💬
15 Tight junction 💬
[1] CFTR 💬 D11724 💬 Galicaftor [1] 299 💬
16 Tight junction 💬
[1] CFTR 💬 D09916 💬 Ivacaftor [1] 299 💬
17 Tight junction 💬
[1] CFTR 💬 D10134 💬 Lumacaftor [1] 299 💬
18 Tight junction 💬
[1] CFTR 💬 D11041 💬 Tezacaftor [1] 299 💬
19 Tight junction 💬
[1] ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
20 Tight junction 💬
[1] ERBB2 💬 D08950 💬 Neratinib [1] 34 💬
21 Tight junction 💬
[1] ERBB2 💬 D11772 💬 Tesevatinib [1] 67 💬
22 Tight junction 💬
[1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
23 Tight junction 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
24 Tight junction 💬
[1] PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬
25 Tight junction 💬
[2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
26 Tight junction 💬
[1] ROCK2 💬 D11815 💬 Belumosudil [2] 51, 85 💬
27 Tight junction 💬
[1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
28 Tight junction 💬
[1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
29 Tight junction 💬
[1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
30 Tight junction 💬
[1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬