Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Purine metabolism 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D00517 💬	Amyl Nitrite	[1] 58 💬
2	Purine metabolism 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
3	Purine metabolism 💬	[1] GUCY2C 💬	D09355 💬	Linaclotide	[2] 6 , 97 💬
4	Purine metabolism 💬	[1] HPRT1 💬	D00161 💬	Mercaptopurine	[4] 65, 96, 97, 164 💬
5	Purine metabolism 💬	[1] HPRT1 💬	D04931 💬	Mercaptopurine	[4] 65, 96, 97, 164 💬
6	Purine metabolism 💬	[1] HPRT1 💬	D08603 💬	Tioguanine	[2] 13, 37 💬
7	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬	D01392 💬	Mizoribine	[8] 46, 49, 51, 53, 66, 94, 222, 224 💬
8	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬	D00752 💬	Mycophenolate mofetil	[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96 ...
9	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬	D05096 💬	Mycophenolic acid	[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95 ...
10	Purine metabolism 💬	[1] NPR1 💬	D05147 💬	Nesiritide	[2] 46, 58 💬

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