Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Nucleotide metabolism 💬	[1] HPRT1 💬	D00161 💬	Mercaptopurine	[4] 65, 96, 97, 164 💬
2	Nucleotide metabolism 💬	[1] HPRT1 💬	D04931 💬	Mercaptopurine	[4] 65, 96, 97, 164 💬
3	Nucleotide metabolism 💬	[1] HPRT1 💬	D08603 💬	Tioguanine	[2] 13, 37 💬
4	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬	D01392 💬	Mizoribine	[8] 46, 49, 51, 53, 66, 94, 222, 224 💬
5	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬	D00752 💬	Mycophenolate mofetil	[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96 ...
6	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬	D05096 💬	Mycophenolic acid	[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95 ...
7	Nucleotide metabolism 💬	[1] RRM1 💬	D01370 💬	Cladribine	[3] 11, 13, 94 💬
8	Nucleotide metabolism 💬	[1] RRM1 💬	D03546 💬	Clofarabine	[5] 19, 20, 60, 234, 326 💬
9	Nucleotide metabolism 💬	[1] RRM1 💬	D07966 💬	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
10	Nucleotide metabolism 💬	[1] RRM2 💬	D00341 💬	Hydroxyurea	[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

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