Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Biosynthesis of cofactors 💬	[1] ALAS1 💬	D11702 💬	Givosiran	[1] 254 💬
2	Biosynthesis of cofactors 💬	[2] ALAS1, ALAS2 💬	D10003 💬	Hemin	[1] 254 💬
3	Biosynthesis of cofactors 💬	[1] ALPL 💬	D10595 💬	Asfotase alfa	[1] 172 💬
4	Biosynthesis of cofactors 💬	[2] DHFR, DHFR2 💬	D00142 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
5	Biosynthesis of cofactors 💬	[1] DHODH 💬	D00749 💬	Leflunomide	[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬
6	Biosynthesis of cofactors 💬	[1] DHODH 💬	D10172 💬	Teriflunomide	[3] 13, 25, 26 💬
7	Biosynthesis of cofactors 💬	[1] GUSB 💬	D11004 💬	Vestronidase alfa	[1] 19 💬
8	Biosynthesis of cofactors 💬	[1] HPD 💬	D05177 💬	Nitisinone	[3] 6 , 164, 241 💬
9	Biosynthesis of cofactors 💬	[2] NQO1, VKORC1 💬	D08682 💬	Warfarin	[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
10	Biosynthesis of cofactors 💬	[1] VKORC1 💬	D08354 💬	Phenindione	[1] 65 💬

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