Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Cellular senescence 💬	[1] CACNA1D 💬	D07450 💬	Amlodipine	[4] 13, 51, 67, 298 💬
2	Cellular senescence 💬	[1] CACNA1D 💬	D01173 💬	Cilnidipine	[1] 67 💬
3	Cellular senescence 💬	[1] CACNA1D 💬	D07845 💬	Diltiazem	[3] 51, 58, 86 💬
4	Cellular senescence 💬	[1] CACNA1D 💬	D00349 💬	Isradipine	[1] 6 💬
5	Cellular senescence 💬	[1] CACNA1D 💬	D08270 💬	Nicardipine	[2] 70, 86 💬
6	Cellular senescence 💬	[1] CACNA1D 💬	D00437 💬	Nifedipine	[2] 50, 81 💬
7	Cellular senescence 💬	[1] CACNA1D 💬	D01908 💬	Nilvadipine	[1] 90 💬
8	Cellular senescence 💬	[1] CACNA1D 💬	D08340 💬	Perhexiline	[2] 58, 272 💬
9	Cellular senescence 💬	[1] CACNA1D 💬	D08441 💬	Propiverine	[1] 226 💬
10	Cellular senescence 💬	[1] CACNA1D 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
11	Cellular senescence 💬	[1] CACNA1D 💬	D02356 💬	Verapamil	[4] 58, 96, 140, 167 💬
12	Cellular senescence 💬	[2] CDK4, CDK6 💬	D10688 💬	Abemaciclib	[1] 34 💬
13	Cellular senescence 💬	[1] IL1A 💬	D11253 💬	Bermekimab	[1] 51 💬
14	Cellular senescence 💬	[1] IL1A 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
15	Cellular senescence 💬	[2] IL1A, IL6 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
16	Cellular senescence 💬	[1] IL6 💬	D12487 💬	Olokizumab	[2] 46, 96 💬
17	Cellular senescence 💬	[1] IL6 💬	D08976 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬
18	Cellular senescence 💬	[1] IL6 💬	D09669 💬	Siltuximab	[2] 28, 331 💬
19	Cellular senescence 💬	[1] IL6 💬	D10080 💬	Sirukumab	[2] 41, 46 💬
20	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬	D10604 💬	Binimetinib	[1] 34 💬
21	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬	D10405 💬	Cobimetinib	[1] 280 💬
22	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬	D11675 💬	Mirdametinib	[1] 34 💬
23	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬	D09666 💬	Selumetinib	[1] 34 💬
24	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
25	Cellular senescence 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D09639 💬	Losmapimod	[2] 113, 222 💬
26	Cellular senescence 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D10959 💬	Neflamapimod	[1] 8 💬
27	Cellular senescence 💬	[1] MTOR 💬	D02714 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
28	Cellular senescence 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
29	Cellular senescence 💬	[1] MTOR 💬	D06068 💬	Temsirolimus	[1] 13 💬
30	Cellular senescence 💬	[1] NFKB1 💬	D01146 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬
31	Cellular senescence 💬	[1] PIK3CA 💬	D11011 💬	Alpelisib	[1] 138 💬
32	Cellular senescence 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	D11158 💬	Leniolisib	[2] 53, 65 💬
33	Cellular senescence 💬	[1] PIK3CD 💬	D11437 💬	Parsaclisib	[3] 35, 53, 61 💬
34	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
35	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D05480 💬	Pimecrolimus	[1] 160 💬
36	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
37	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
38	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D09033 💬	Voclosporin	[2] 49, 222 💬
39	Cellular senescence 💬	[1] RAF1 💬	D08524 💬	Sorafenib	[2] 34, 86 💬
40	Cellular senescence 💬	[1] RELA 💬	D12181 💬	Edasalonexent	[1] 113 💬
41	Cellular senescence 💬	[3] TGFB1, TGFB2, TGFB3 💬	D09620 💬	Fresolimumab	[3] 51, 85, 222 💬