Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Osteoclast differentiation 💬
 [1] BTK 💬 D10893 💬 Acalabrutinib [2] 46, 61 💬
2 Osteoclast differentiation 💬
 [1] BTK 💬 D11478 💬 Branebrutinib [3] 46, 49, 53 💬
3 Osteoclast differentiation 💬
 [1] BTK 💬 D12467 💬 Evobrutinib [3] 13, 46, 49 💬
4 Osteoclast differentiation 💬
 [1] BTK 💬 D11457 💬 Fenebrutinib [1] 13 💬
5 Osteoclast differentiation 💬
 [1] BTK 💬 D10223 💬 Ibrutinib [3] 28, 60, 61 💬
6 Osteoclast differentiation 💬
 [1] BTK 💬 D12160 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
7 Osteoclast differentiation 💬
 [1] BTK 💬 D12285 💬 Remibrutinib [2] 13, 53 💬
8 Osteoclast differentiation 💬
 [1] BTK 💬 D11422 💬 Zanubrutinib [5] 13, 63, 222, 300, 331 💬
9 Osteoclast differentiation 💬
 [1] CSF1R 💬 D11270 💬 Pexidartinib [1] 34 💬
10 Osteoclast differentiation 💬
 [1] CSF1R 💬 D08552 💬 Sunitinib [2] 28, 34 💬
11 Osteoclast differentiation 💬
 [2] FYN, LCK 💬 D03658 💬 Dasatinib [2] 51, 85 💬
12 Osteoclast differentiation 💬
 [2] FYN, LCK 💬 D06414 💬 Dasatinib [2] 51, 85 💬
13 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [3] 46, 49, 53 💬
14 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
15 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
16 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
17 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
18 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
19 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
20 Osteoclast differentiation 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [3] 49, 65, 107 💬
21 Osteoclast differentiation 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
22 Osteoclast differentiation 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
23 Osteoclast differentiation 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
24 Osteoclast differentiation 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
25 Osteoclast differentiation 💬
 [3] IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
26 Osteoclast differentiation 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
27 Osteoclast differentiation 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
28 Osteoclast differentiation 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
29 Osteoclast differentiation 💬
 [1] JAK1 💬 D11400 💬 Abrocitinib [1] 84 💬
30 Osteoclast differentiation 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
31 Osteoclast differentiation 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
32 Osteoclast differentiation 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [4] 46, 51, 97, 228 💬
33 Osteoclast differentiation 💬
 [1] JAK1 💬 D10653 💬 Peficitinib [1] 46 💬
34 Osteoclast differentiation 💬
 [1] JAK1 💬 D09959 💬 Ruxolitinib [3] 60, 65, 228 💬
35 Osteoclast differentiation 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
36 Osteoclast differentiation 💬
 [2] JAK1, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
37 Osteoclast differentiation 💬
 [1] LILRA4 💬 D11778 💬 Daxdilimab [2] 49, 50 💬
38 Osteoclast differentiation 💬
 [1] MAP2K1 💬 D10604 💬 Binimetinib [1] 34 💬
39 Osteoclast differentiation 💬
 [1] MAP2K1 💬 D10405 💬 Cobimetinib [1] 280 💬
40 Osteoclast differentiation 💬
 [1] MAP2K1 💬 D11675 💬 Mirdametinib [1] 34 💬
41 Osteoclast differentiation 💬
 [1] MAP2K1 💬 D09666 💬 Selumetinib [1] 34 💬
42 Osteoclast differentiation 💬
 [1] MAP2K1 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
43 Osteoclast differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
44 Osteoclast differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
45 Osteoclast differentiation 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
46 Osteoclast differentiation 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
47 Osteoclast differentiation 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
48 Osteoclast differentiation 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
49 Osteoclast differentiation 💬
 [1] PPARG 💬 D12242 💬 Bocidelpar [1] 113 💬
50 Osteoclast differentiation 💬
 [1] PPARG 💬 D11603 💬 Leriglitazone [1] 20 💬
51 Osteoclast differentiation 💬
 [1] PPARG 💬 D08378 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
52 Osteoclast differentiation 💬
 [1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
53 Osteoclast differentiation 💬
 [1] PPARG 💬 D11256 💬 Seladelpar [2] 93, 94 💬
54 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
55 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
56 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
57 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
58 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
59 Osteoclast differentiation 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
60 Osteoclast differentiation 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
61 Osteoclast differentiation 💬
 [2] TGFB1, TGFB2 💬 D09620 💬 Fresolimumab [3] 51, 85, 222 💬
62 Osteoclast differentiation 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
63 Osteoclast differentiation 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
64 Osteoclast differentiation 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
65 Osteoclast differentiation 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
66 Osteoclast differentiation 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
67 Osteoclast differentiation 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
68 Osteoclast differentiation 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
69 Osteoclast differentiation 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
70 Osteoclast differentiation 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
71 Osteoclast differentiation 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
72 Osteoclast differentiation 💬
 [1] TNFSF11 💬 D03684 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬
73 Osteoclast differentiation 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [3] 49, 96, 97 💬