Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Pathways of neurodegeneration - multiple diseases 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Pathways of neurodegeneration - multiple diseases 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
3 Pathways of neurodegeneration - multiple diseases 💬
 [2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
4 Pathways of neurodegeneration - multiple diseases 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
5 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
6 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
7 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
8 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
9 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
10 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
11 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
12 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
13 Pathways of neurodegeneration - multiple diseases 💬
 [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM3, CHRM5 💬 D08441 💬 Propiverine [1] 226 💬
14 Pathways of neurodegeneration - multiple diseases 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
15 Pathways of neurodegeneration - multiple diseases 💬
 [1] CASP9 💬 D11195 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
16 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D00113 💬 Atropine [2]  2 , 299 💬
17 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D00270 💬 Chlorpromazine [1] 254 💬
18 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D00465 💬 Oxybutynin [3]  6 , 13, 53 💬
19 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D00138 💬 Scopolamine [1]  2  💬
20 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D08638 💬 Trihexyphenidyl [2]  5 ,  6  💬
21 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 D00397 💬 Tropicamide [1]  6  💬
22 Pathways of neurodegeneration - multiple diseases 💬
 [4] CHRM1, CHRM3, CHRM5, SIGMAR1 💬 D11383 💬 Blarcamesine [1] 156 💬
23 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D07667 💬 Cevimeline [1] 53 💬
24 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D03654 💬 Darifenacin [2]  6 , 13 💬
25 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D07226 💬 Fesoterodine [1]  6  💬
26 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D00525 💬 Pilocarpine [3]  6 , 53, 299 💬
27 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D08522 💬 Solifenacin [3]  6 , 13, 53 💬
28 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRM3 💬 D00646 💬 Tolterodine [2] 17, 53 💬
29 Pathways of neurodegeneration - multiple diseases 💬
 [1] CHRNA7 💬 D03365 💬 Nicotine [3]  6 , 13, 84 💬
30 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
31 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
32 Pathways of neurodegeneration - multiple diseases 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
33 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
34 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
35 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
36 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
37 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D09917 💬 Latrepirdine [1]  8  💬
38 Pathways of neurodegeneration - multiple diseases 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
39 Pathways of neurodegeneration - multiple diseases 💬
 [6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
40 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
41 Pathways of neurodegeneration - multiple diseases 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
42 Pathways of neurodegeneration - multiple diseases 💬
 [4] IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
43 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
44 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
45 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL6 💬 D12487 💬 Olokizumab [2] 46, 96 💬
46 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
47 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
48 Pathways of neurodegeneration - multiple diseases 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
49 Pathways of neurodegeneration - multiple diseases 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
50 Pathways of neurodegeneration - multiple diseases 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
51 Pathways of neurodegeneration - multiple diseases 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
52 Pathways of neurodegeneration - multiple diseases 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
53 Pathways of neurodegeneration - multiple diseases 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
54 Pathways of neurodegeneration - multiple diseases 💬
 [1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
55 Pathways of neurodegeneration - multiple diseases 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
56 Pathways of neurodegeneration - multiple diseases 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
57 Pathways of neurodegeneration - multiple diseases 💬
 [1] MAPT 💬 D11210 💬 Flortaucipir [3]  5 ,  7 , 127 💬
58 Pathways of neurodegeneration - multiple diseases 💬
 [1] MAPT 💬 D11293 💬 Gosuranemab [1]  5  💬
59 Pathways of neurodegeneration - multiple diseases 💬
 [1] MAPT 💬 D11384 💬 Hydromethylthionine mesylate [1] 127 💬
60 Pathways of neurodegeneration - multiple diseases 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
61 Pathways of neurodegeneration - multiple diseases 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
62 Pathways of neurodegeneration - multiple diseases 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
63 Pathways of neurodegeneration - multiple diseases 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
64 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
65 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
66 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
67 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
68 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
69 Pathways of neurodegeneration - multiple diseases 💬
 [1] PRKCB 💬 D11935 💬 Enzastaurin [1] 168 💬
70 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSEN1 💬 D09010 💬 Tarenflurbil [1] 13 💬
71 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
72 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 D08880 💬 Carfilzomib [1] 28 💬
73 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 D10130 💬 Ixazomib [5] 13, 16, 28, 51, 61 💬
74 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D01545 💬 Aceclofenac [1] 46 💬
75 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00217 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
76 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
77 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00567 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
78 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
79 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00130 💬 Diflunisal [1] 28 💬
80 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00315 💬 Etodolac [1] 46 💬
81 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D03710 💬 Etoricoxib [2] 46, 271 💬
82 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00330 💬 Flurbiprofen [3] 13, 21, 46 💬
83 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00126 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
84 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00141 💬 Indomethacin [3] 225, 271, 298 💬
85 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00132 💬 Ketoprofen [1] 46 💬
86 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D08104 💬 Ketorolac [2] 70, 226 💬
87 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D08149 💬 Loxoprofen [2] 46, 271 💬
88 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D03714 💬 Lumiracoxib [1] 46 💬
89 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00969 💬 Meloxicam [4] 46, 49, 271, 296 💬
90 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00118 💬 Naproxen [4] 13, 46, 107, 271 💬
91 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D01049 💬 Nimesulide [1] 46 💬
92 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D03716 💬 Parecoxib [2] 46, 271 💬
93 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00568 💬 Rofecoxib [1] 46 💬
94 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00428 💬 Salsalate [1]  5  💬
95 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D00120 💬 Sulindac [1] 206 💬
96 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D01183 💬 Tolfenamic acid [1]  5  💬
97 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 D02709 💬 Valdecoxib [1] 46 💬
98 Pathways of neurodegeneration - multiple diseases 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
99 Pathways of neurodegeneration - multiple diseases 💬
 [1] SIGMAR1 💬 D07945 💬 Fenfluramine [4] 140, 144, 145, 149 💬
100 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D03215 💬 Armodafinil [3]  6 , 13, 84 💬
101 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
102 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D08130 💬 Lisdexamfetamine [1] 13 💬
103 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
104 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 D05458 💬 Phentermine [1] 97 💬
105 Pathways of neurodegeneration - multiple diseases 💬
 [1] SNCA 💬 D11420 💬 Prasinezumab [1]  6  💬
106 Pathways of neurodegeneration - multiple diseases 💬
 [1] SOD1 💬 D11811 💬 Tofersen [1]  2  💬
107 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
108 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
109 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
110 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
111 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
112 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
113 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
114 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
115 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
116 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D11595 💬 Belantamab mafodotin [1] 28 💬
117 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D09587 💬 Brentuximab vedotin [2] 49, 51 💬
118 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D00570 💬 Colchicine [7]  2 , 42, 46, 56, 93, 210, 266 💬
119 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D00491 💬 Paclitaxel [2] 46, 85 💬
120 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D08675 💬 Vinblastine [2] 34, 65 💬
121 Pathways of neurodegeneration - multiple diseases 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D08679 💬 Vincristine [4] 26, 34, 65, 331 💬