Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Morphine addiction 💬	[1] ADORA1 💬	D00045 💬	Adenosine	[3] 13, 58, 65 💬
2	Morphine addiction 💬	[1] ADORA1 💬	D02769 💬	Adenosine phosphate	[1] 46 💬
3	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, P ...	D00227 💬	Aminophylline	[1] 63 💬
4	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, P ...	D00371 💬	Theophylline	[2] 236, 299 💬
5	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, P ...	D06103 💬	Theophylline	[2] 236, 299 💬
6	Morphine addiction 💬	[9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D00528 💬	Caffeine	[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬
7	Morphine addiction 💬	[9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D01453 💬	Caffeine	[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬
8	Morphine addiction 💬	[1] CACNA1B 💬	D01173 💬	Cilnidipine	[1] 67 💬
9	Morphine addiction 💬	[1] DRD1 💬	D07460 💬	Apomorphine	[3] 5 , 6 , 7 💬
10	Morphine addiction 💬	[1] DRD1 💬	D09886 💬	Dexpramipexole	[1] 2 💬

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