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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Legionellosis 💬	[1] C3 💬	D11613 💬	Pegcetacoplan	[4] 2 , 61, 62, 222 💬
2	Legionellosis 💬	[1] CASP9 💬	D11195 💬	Rimiducid	[6] 19, 60, 65, 284, 285, 326 💬
3	Legionellosis 💬	[2] IL12A, IL12B 💬	D09214 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
4	Legionellosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
5	Legionellosis 💬	[1] IL1B 💬	D09911 💬	Gevokizumab	[4] 41, 50, 56, 269 💬
6	Legionellosis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
7	Legionellosis 💬	[3] IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
8	Legionellosis 💬	[1] IL6 💬	D12487 💬	Olokizumab	[2] 46, 96 💬
9	Legionellosis 💬	[1] IL6 💬	D09669 💬	Siltuximab	[2] 28, 331 💬
10	Legionellosis 💬	[1] IL6 💬	D10080 💬	Sirukumab	[2] 41, 46 💬
11	Legionellosis 💬	[2] IL6, TNF 💬	D08976 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬
12	Legionellosis 💬	[1] NFKB1 💬	D01146 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬
13	Legionellosis 💬	[1] RELA 💬	D12181 💬	Edasalonexent	[1] 113 💬
14	Legionellosis 💬	[1] TNF 💬	D02597 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
15	Legionellosis 💬	[1] TNF 💬	D03441 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬
16	Legionellosis 💬	[1] TNF 💬	D00742 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
17	Legionellosis 💬	[1] TNF 💬	D04358 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬
18	Legionellosis 💬	[1] TNF 💬	D02598 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
19	Legionellosis 💬	[1] TNF 💬	D04687 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬
20	Legionellosis 💬	[1] TNF 💬	D09944 💬	Ozoralizumab	[1] 46 💬
21	Legionellosis 💬	[1] TNF 💬	D05393 💬	Pegsunercept	[1] 46 💬
22	Legionellosis 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
23	Leishmaniasis 💬	[1] C3 💬	D11613 💬	Pegcetacoplan	[4] 2 , 61, 62, 222 💬
24	Leishmaniasis 💬	[1] IFNG 💬	D11120 💬	Emapalumab	[3] 49, 65, 107 💬
25	Leishmaniasis 💬	[1] IFNG 💬	D04242 💬	Fontolizumab	[1] 46 💬
26	Leishmaniasis 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
27	Leishmaniasis 💬	[4] IL10, IL1A, IL1B, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
28	Leishmaniasis 💬	[2] IL12A, IL12B 💬	D09214 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
29	Leishmaniasis 💬	[1] IL1A 💬	D11253 💬	Bermekimab	[1] 51 💬
30	Leishmaniasis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
31	Leishmaniasis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
32	Leishmaniasis 💬	[1] IL1B 💬	D09911 💬	Gevokizumab	[4] 41, 50, 56, 269 💬
33	Leishmaniasis 💬	[1] IL4 💬	D03117 💬	Binetrakin	[1] 46 💬
34	Leishmaniasis 💬	[1] ITGA4 💬	D10540 💬	Abrilumab	[2] 96, 97 💬
35	Leishmaniasis 💬	[1] ITGA4 💬	D06590 💬	Firategrast	[1] 13 💬
36	Leishmaniasis 💬	[1] ITGA4 💬	D06886 💬	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬
37	Leishmaniasis 💬	[1] ITGA4 💬	D08083 💬	Vedolizumab	[3] 94, 96, 97 💬
38	Leishmaniasis 💬	[1] JAK1 💬	D11400 💬	Abrocitinib	[1] 84 💬
39	Leishmaniasis 💬	[1] JAK1 💬	D10871 💬	Filgotinib	[6] 46, 53, 96, 97, 222, 271 💬
40	Leishmaniasis 💬	[1] JAK1 💬	D10944 💬	Itacitinib	[4] 46, 51, 97, 228 💬
41	Leishmaniasis 💬	[1] JAK1 💬	D10994 💬	Upadacitinib	[8] 40, 41, 46, 49, 96, 97, 107, 271 💬
42	Leishmaniasis 💬	[2] JAK1, JAK2 💬	D10308 💬	Baricitinib	[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
43	Leishmaniasis 💬	[2] JAK1, JAK2 💬	D10653 💬	Peficitinib	[1] 46 💬
44	Leishmaniasis 💬	[2] JAK1, JAK2 💬	D09959 💬	Ruxolitinib	[3] 60, 65, 228 💬
45	Leishmaniasis 💬	[2] JAK1, JAK2 💬	D09970 💬	Tofacitinib	[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
46	Leishmaniasis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D09639 💬	Losmapimod	[2] 113, 222 💬
47	Leishmaniasis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D10959 💬	Neflamapimod	[1] 8 💬
48	Leishmaniasis 💬	[1] NFKB1 💬	D01146 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬
49	Leishmaniasis 💬	[1] PRKCB 💬	D11935 💬	Enzastaurin	[1] 168 💬
50	Leishmaniasis 💬	[1] PTGS2 💬	D01545 💬	Aceclofenac	[1] 46 💬
51	Leishmaniasis 💬	[1] PTGS2 💬	D00217 💬	Acetaminophen	[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
52	Leishmaniasis 💬	[1] PTGS2 💬	D00109 💬	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
53	Leishmaniasis 💬	[1] PTGS2 💬	D00567 💬	Celecoxib	[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
54	Leishmaniasis 💬	[1] PTGS2 💬	D07816 💬	Diclofenac	[5] 13, 34, 46, 78, 271 💬
55	Leishmaniasis 💬	[1] PTGS2 💬	D00130 💬	Diflunisal	[1] 28 💬
56	Leishmaniasis 💬	[1] PTGS2 💬	D00315 💬	Etodolac	[1] 46 💬
57	Leishmaniasis 💬	[1] PTGS2 💬	D03710 💬	Etoricoxib	[2] 46, 271 💬
58	Leishmaniasis 💬	[1] PTGS2 💬	D00330 💬	Flurbiprofen	[3] 13, 21, 46 💬
59	Leishmaniasis 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[7] 13, 46, 65, 107, 113, 271, 299 💬
60	Leishmaniasis 💬	[1] PTGS2 💬	D00141 💬	Indomethacin	[3] 225, 271, 298 💬
61	Leishmaniasis 💬	[1] PTGS2 💬	D00132 💬	Ketoprofen	[1] 46 💬
62	Leishmaniasis 💬	[1] PTGS2 💬	D08104 💬	Ketorolac	[2] 70, 226 💬
63	Leishmaniasis 💬	[1] PTGS2 💬	D08149 💬	Loxoprofen	[2] 46, 271 💬
64	Leishmaniasis 💬	[1] PTGS2 💬	D03714 💬	Lumiracoxib	[1] 46 💬
65	Leishmaniasis 💬	[1] PTGS2 💬	D00969 💬	Meloxicam	[4] 46, 49, 271, 296 💬
66	Leishmaniasis 💬	[1] PTGS2 💬	D00118 💬	Naproxen	[4] 13, 46, 107, 271 💬
67	Leishmaniasis 💬	[1] PTGS2 💬	D01049 💬	Nimesulide	[1] 46 💬
68	Leishmaniasis 💬	[1] PTGS2 💬	D03716 💬	Parecoxib	[2] 46, 271 💬
69	Leishmaniasis 💬	[1] PTGS2 💬	D00568 💬	Rofecoxib	[1] 46 💬
70	Leishmaniasis 💬	[1] PTGS2 💬	D00428 💬	Salsalate	[1] 5 💬
71	Leishmaniasis 💬	[1] PTGS2 💬	D00120 💬	Sulindac	[1] 206 💬
72	Leishmaniasis 💬	[1] PTGS2 💬	D01183 💬	Tolfenamic acid	[1] 5 💬
73	Leishmaniasis 💬	[1] PTGS2 💬	D02709 💬	Valdecoxib	[1] 46 💬
74	Leishmaniasis 💬	[1] RELA 💬	D12181 💬	Edasalonexent	[1] 113 💬
75	Leishmaniasis 💬	[3] TGFB1, TGFB2, TGFB3 💬	D09620 💬	Fresolimumab	[3] 51, 85, 222 💬
76	Leishmaniasis 💬	[1] TNF 💬	D02597 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
77	Leishmaniasis 💬	[1] TNF 💬	D03441 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬
78	Leishmaniasis 💬	[1] TNF 💬	D00742 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
79	Leishmaniasis 💬	[1] TNF 💬	D04358 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬
80	Leishmaniasis 💬	[1] TNF 💬	D02598 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
81	Leishmaniasis 💬	[1] TNF 💬	D04687 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬
82	Leishmaniasis 💬	[1] TNF 💬	D09944 💬	Ozoralizumab	[1] 46 💬
83	Leishmaniasis 💬	[1] TNF 💬	D05393 💬	Pegsunercept	[1] 46 💬
84	Leishmaniasis 💬	[1] TNF 💬	D08976 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬
85	Leishmaniasis 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
86	Leukocyte transendothelial migration 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[5] 19, 20, 65, 285, 299 💬
87	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	D10540 💬	Abrilumab	[2] 96, 97 💬
88	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	D06590 💬	Firategrast	[1] 13 💬
89	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	D06886 💬	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬
90	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	D08083 💬	Vedolizumab	[3] 94, 96, 97 💬
91	Leukocyte transendothelial migration 💬	[1] ITGAL 💬	D03959 💬	Efalizumab	[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
92	Leukocyte transendothelial migration 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D09639 💬	Losmapimod	[2] 113, 222 💬
93	Leukocyte transendothelial migration 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D10959 💬	Neflamapimod	[1] 8 💬
94	Leukocyte transendothelial migration 💬	[1] PIK3CA 💬	D11011 💬	Alpelisib	[1] 138 💬
95	Leukocyte transendothelial migration 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	D11158 💬	Leniolisib	[2] 53, 65 💬
96	Leukocyte transendothelial migration 💬	[1] PIK3CD 💬	D11437 💬	Parsaclisib	[3] 35, 53, 61 💬
97	Leukocyte transendothelial migration 💬	[1] PRKCB 💬	D11935 💬	Enzastaurin	[1] 168 💬
98	Leukocyte transendothelial migration 💬	[2] ROCK1, ROCK2 💬	D07941 💬	Fasudil	[4] 2 , 5 , 7 , 51 💬
99	Leukocyte transendothelial migration 💬	[1] ROCK2 💬	D11815 💬	Belumosudil	[2] 51, 85 💬
100	Lipid and atherosclerosis 💬	[1] BCL2 💬	D10679 💬	Venetoclax	[1] 28 💬
101	Lipid and atherosclerosis 💬	[1] CASP9 💬	D11195 💬	Rimiducid	[6] 19, 60, 65, 284, 285, 326 💬
102	Lipid and atherosclerosis 💬	[4] CCL2, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
103	Lipid and atherosclerosis 💬	[1] CD40 💬	D11357 💬	Bleselumab	[1] 222 💬
104	Lipid and atherosclerosis 💬	[1] CD40 💬	D11610 💬	Iscalimab	[2] 49, 53 💬
105	Lipid and atherosclerosis 💬	[1] CD40 💬	D11597 💬	Ravagalimab	[2] 53, 97 💬
106	Lipid and atherosclerosis 💬	[1] CD40LG 💬	D06193 💬	Toralizumab	[1] 63 💬
107	Lipid and atherosclerosis 💬	[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬	D09662 💬	Rontalizumab	[1] 49 💬
108	Lipid and atherosclerosis 💬	[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬	D09668 💬	Sifalimumab	[1] 49 💬
109	Lipid and atherosclerosis 💬	[2] IL12A, IL12B 💬	D09214 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
110	Lipid and atherosclerosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
111	Lipid and atherosclerosis 💬	[1] IL1B 💬	D09911 💬	Gevokizumab	[4] 41, 50, 56, 269 💬
112	Lipid and atherosclerosis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
113	Lipid and atherosclerosis 💬	[1] IL6 💬	D12487 💬	Olokizumab	[2] 46, 96 💬
114	Lipid and atherosclerosis 💬	[1] IL6 💬	D09669 💬	Siltuximab	[2] 28, 331 💬
115	Lipid and atherosclerosis 💬	[1] IL6 💬	D10080 💬	Sirukumab	[2] 41, 46 💬
116	Lipid and atherosclerosis 💬	[2] IL6, TNF 💬	D08976 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬
117	Lipid and atherosclerosis 💬	[1] JAK2 💬	D10308 💬	Baricitinib	[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
118	Lipid and atherosclerosis 💬	[1] JAK2 💬	D10653 💬	Peficitinib	[1] 46 💬
119	Lipid and atherosclerosis 💬	[1] JAK2 💬	D09959 💬	Ruxolitinib	[3] 60, 65, 228 💬
120	Lipid and atherosclerosis 💬	[1] JAK2 💬	D09970 💬	Tofacitinib	[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
121	Lipid and atherosclerosis 💬	[1] MAP3K5 💬	D10988 💬	Selonsertib	[1] 86 💬
122	Lipid and atherosclerosis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D09639 💬	Losmapimod	[2] 113, 222 💬
123	Lipid and atherosclerosis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	D10959 💬	Neflamapimod	[1] 8 💬
124	Lipid and atherosclerosis 💬	[1] NFE2L2 💬	D10964 💬	Omaveloxolone	[1] 18 💬
125	Lipid and atherosclerosis 💬	[1] NFKB1 💬	D01146 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬
126	Lipid and atherosclerosis 💬	[1] PIK3CA 💬	D11011 💬	Alpelisib	[1] 138 💬
127	Lipid and atherosclerosis 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	D11158 💬	Leniolisib	[2] 53, 65 💬
128	Lipid and atherosclerosis 💬	[1] PIK3CD 💬	D11437 💬	Parsaclisib	[3] 35, 53, 61 💬
129	Lipid and atherosclerosis 💬	[1] PPARG 💬	D12242 💬	Bocidelpar	[1] 113 💬
130	Lipid and atherosclerosis 💬	[1] PPARG 💬	D11603 💬	Leriglitazone	[1] 20 💬
131	Lipid and atherosclerosis 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
132	Lipid and atherosclerosis 💬	[1] PPARG 💬	D08491 💬	Rosiglitazone	[5] 46, 75, 97, 222, 265 💬
133	Lipid and atherosclerosis 💬	[1] PPARG 💬	D11256 💬	Seladelpar	[2] 93, 94 💬
134	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
135	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D05480 💬	Pimecrolimus	[1] 160 💬
136	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
137	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
138	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D09033 💬	Voclosporin	[2] 49, 222 💬
139	Lipid and atherosclerosis 💬	[1] RELA 💬	D12181 💬	Edasalonexent	[1] 113 💬
140	Lipid and atherosclerosis 💬	[1] ROCK2 💬	D11815 💬	Belumosudil	[2] 51, 85 💬
141	Lipid and atherosclerosis 💬	[1] ROCK2 💬	D07941 💬	Fasudil	[4] 2 , 5 , 7 , 51 💬
142	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	D02754 💬	Acitretin	[1] 37 💬
143	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	D02815 💬	Alitretinoin	[1] 49 💬
144	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	D03106 💬	Bexarotene	[2] 13, 75 💬
145	Lipid and atherosclerosis 💬	[1] SRC 💬	D03252 💬	Bosutinib	[2] 2 , 67 💬
146	Lipid and atherosclerosis 💬	[1] SRC 💬	D03658 💬	Dasatinib	[2] 51, 85 💬
147	Lipid and atherosclerosis 💬	[1] SRC 💬	D06414 💬	Dasatinib	[2] 51, 85 💬
148	Lipid and atherosclerosis 💬	[1] SRC 💬	D09664 💬	Saracatinib	[3] 6 , 89, 272 💬
149	Lipid and atherosclerosis 💬	[1] TNF 💬	D02597 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
150	Lipid and atherosclerosis 💬	[1] TNF 💬	D03441 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬
151	Lipid and atherosclerosis 💬	[1] TNF 💬	D00742 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
152	Lipid and atherosclerosis 💬	[1] TNF 💬	D04358 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬
153	Lipid and atherosclerosis 💬	[1] TNF 💬	D02598 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
154	Lipid and atherosclerosis 💬	[1] TNF 💬	D04687 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬
155	Lipid and atherosclerosis 💬	[1] TNF 💬	D09944 💬	Ozoralizumab	[1] 46 💬
156	Lipid and atherosclerosis 💬	[1] TNF 💬	D05393 💬	Pegsunercept	[1] 46 💬
157	Lipid and atherosclerosis 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
158	Long-term depression 💬	[1] BRAF 💬	D10064 💬	Dabrafenib	[1] 34 💬
159	Long-term depression 💬	[2] BRAF, RAF1 💬	D08524 💬	Sorafenib	[2] 34, 86 💬
160	Long-term depression 💬	[1] CRHR1 💬	D03905 💬	Corticorelin	[1] 75 💬
161	Long-term depression 💬	[1] CRHR1 💬	D03592 💬	Corticorelin ovine triflutate	[1] 75 💬
162	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
163	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D00775 💬	Riluzole	[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬
164	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D02696 💬	Talampanel	[2] 2 , 6 💬
165	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
166	Long-term depression 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D00517 💬	Amyl Nitrite	[1] 58 💬
167	Long-term depression 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
168	Long-term depression 💬	[1] IGF1R 💬	D09925 💬	Linsitinib	[1] 232 💬
169	Long-term depression 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
170	Long-term depression 💬	[1] IGF1R 💬	D09680 💬	Teprotumumab	[1] 51 💬
171	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	D10604 💬	Binimetinib	[1] 34 💬
172	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	D10405 💬	Cobimetinib	[1] 280 💬
173	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	D11675 💬	Mirdametinib	[1] 34 💬
174	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	D09666 💬	Selumetinib	[1] 34 💬
175	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
176	Long-term depression 💬	[1] PRKCB 💬	D11935 💬	Enzastaurin	[1] 168 💬
177	Long-term potentiation 💬	[1] BRAF 💬	D10064 💬	Dabrafenib	[1] 34 💬
178	Long-term potentiation 💬	[2] BRAF, RAF1 💬	D08524 💬	Sorafenib	[2] 34, 86 💬
179	Long-term potentiation 💬	[1] CACNA1C 💬	D07450 💬	Amlodipine	[4] 13, 51, 67, 298 💬
180	Long-term potentiation 💬	[1] CACNA1C 💬	D01173 💬	Cilnidipine	[1] 67 💬
181	Long-term potentiation 💬	[1] CACNA1C 💬	D07845 💬	Diltiazem	[3] 51, 58, 86 💬
182	Long-term potentiation 💬	[1] CACNA1C 💬	D00349 💬	Isradipine	[1] 6 💬
183	Long-term potentiation 💬	[1] CACNA1C 💬	D08270 💬	Nicardipine	[2] 70, 86 💬
184	Long-term potentiation 💬	[1] CACNA1C 💬	D00437 💬	Nifedipine	[2] 50, 81 💬
185	Long-term potentiation 💬	[1] CACNA1C 💬	D01908 💬	Nilvadipine	[1] 90 💬
186	Long-term potentiation 💬	[1] CACNA1C 💬	D08340 💬	Perhexiline	[2] 58, 272 💬
187	Long-term potentiation 💬	[1] CACNA1C 💬	D08441 💬	Propiverine	[1] 226 💬
188	Long-term potentiation 💬	[1] CACNA1C 💬	D02356 💬	Verapamil	[4] 58, 96, 140, 167 💬
189	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬	D00537 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬
190	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬	D08964 💬	Perampanel	[3] 2 , 6 , 144 💬
191	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬	D02696 💬	Talampanel	[2] 2 , 6 💬
192	Long-term potentiation 💬	[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D00775 💬	Riluzole	[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬
193	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07058 💬	Acamprosate	[2] 6 , 206 💬
194	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07441 💬	Amantadine	[4] 6 , 8 , 13, 127 💬
195	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03742 💬	Dextromethorphan	[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
196	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D07283 💬	Esketamine	[3] 2 , 4 , 70 💬
197	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D08098 💬	Ketamine	[8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬
198	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D09917 💬	Latrepirdine	[1] 8 💬
199	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D08174 💬	Memantine	[8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬
200	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	D10604 💬	Binimetinib	[1] 34 💬
201	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	D10405 💬	Cobimetinib	[1] 280 💬
202	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	D11675 💬	Mirdametinib	[1] 34 💬
203	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	D09666 💬	Selumetinib	[1] 34 💬
204	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
205	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
206	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D05480 💬	Pimecrolimus	[1] 160 💬
207	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
208	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
209	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D09033 💬	Voclosporin	[2] 49, 222 💬
210	Long-term potentiation 💬	[1] PRKCB 💬	D11935 💬	Enzastaurin	[1] 168 💬
211	Longevity regulating pathway 💬	[1] IGF1R 💬	D09925 💬	Linsitinib	[1] 232 💬
212	Longevity regulating pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
213	Longevity regulating pathway 💬	[1] IGF1R 💬	D09680 💬	Teprotumumab	[1] 51 💬
214	Longevity regulating pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
215	Longevity regulating pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
216	Longevity regulating pathway 💬	[1] INSR 💬	D03230 💬	Insulin human	[2] 96, 156 💬
217	Longevity regulating pathway 💬	[1] MTOR 💬	D02714 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
218	Longevity regulating pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
219	Longevity regulating pathway 💬	[1] MTOR 💬	D06068 💬	Temsirolimus	[1] 13 💬
220	Longevity regulating pathway 💬	[1] NFKB1 💬	D01146 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬
221	Longevity regulating pathway 💬	[1] PIK3CA 💬	D11011 💬	Alpelisib	[1] 138 💬
222	Longevity regulating pathway 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	D11158 💬	Leniolisib	[2] 53, 65 💬
223	Longevity regulating pathway 💬	[1] PIK3CD 💬	D11437 💬	Parsaclisib	[3] 35, 53, 61 💬
224	Longevity regulating pathway 💬	[1] PPARG 💬	D12242 💬	Bocidelpar	[1] 113 💬
225	Longevity regulating pathway 💬	[1] PPARG 💬	D11603 💬	Leriglitazone	[1] 20 💬
226	Longevity regulating pathway 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
227	Longevity regulating pathway 💬	[1] PPARG 💬	D08491 💬	Rosiglitazone	[5] 46, 75, 97, 222, 265 💬
228	Longevity regulating pathway 💬	[1] PPARG 💬	D11256 💬	Seladelpar	[2] 93, 94 💬
229	Longevity regulating pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
230	Longevity regulating pathway 💬	[1] RELA 💬	D12181 💬	Edasalonexent	[1] 113 💬
231	Longevity regulating pathway - multiple species 💬	[2] HDAC1, HDAC2 💬	D06320 💬	Vorinostat	[2] 75, 96 💬
232	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	D09925 💬	Linsitinib	[1] 232 💬
233	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
234	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	D09680 💬	Teprotumumab	[1] 51 💬
235	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
236	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
237	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	D03230 💬	Insulin human	[2] 96, 156 💬
238	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	D02714 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
239	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
240	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	D06068 💬	Temsirolimus	[1] 13 💬
241	Longevity regulating pathway - multiple species 💬	[1] PIK3CA 💬	D11011 💬	Alpelisib	[1] 138 💬
242	Longevity regulating pathway - multiple species 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	D11158 💬	Leniolisib	[2] 53, 65 💬
243	Longevity regulating pathway - multiple species 💬	[1] PIK3CD 💬	D11437 💬	Parsaclisib	[3] 35, 53, 61 💬
244	Longevity regulating pathway - multiple species 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
245	Longevity regulating pathway - multiple species 💬	[1] SOD1 💬	D11811 💬	Tofersen	[1] 2 💬
246	Lysosome 💬	[1] ARSB 💬	D06565 💬	Galsulfase	[1] 19 💬
247	Lysosome 💬	[1] CTSC 💬	D12120 💬	Brensocatib	[1] 299 💬
248	Lysosome 💬	[1] GAA 💬	D00216 💬	Acarbose	[1] 298 💬
249	Lysosome 💬	[1] GAA 💬	D03207 💬	Alglucosidase alfa	[1] 256 💬
250	Lysosome 💬	[1] GAA 💬	D11744 💬	Avalglucosidase alfa	[1] 256 💬
251	Lysosome 💬	[1] GAA 💬	D11798 💬	Cipaglucosidase alfa	[1] 256 💬
252	Lysosome 💬	[1] GAA 💬	D09605 💬	Duvoglustat	[1] 256 💬
253	Lysosome 💬	[1] GALNS 💬	D10333 💬	Elosulfase alfa	[1] 19 💬
254	Lysosome 💬	[1] GBA1 💬	D02810 💬	Alglucerase	[1] 19 💬
255	Lysosome 💬	[1] GBA1 💬	D03020 💬	Imiglucerase	[1] 19 💬
256	Lysosome 💬	[1] GBA1 💬	D09675 💬	Taliglucerase alfa	[1] 19 💬
257	Lysosome 💬	[1] GBA1 💬	D09029 💬	Velaglucerase alfa	[1] 19 💬
258	Lysosome 💬	[1] GLA 💬	D02784 💬	Agalsidase alfa	[1] 19 💬
259	Lysosome 💬	[1] GLA 💬	D03228 💬	Agalsidase beta	[1] 19 💬
260	Lysosome 💬	[1] GUSB 💬	D11004 💬	Vestronidase alfa	[1] 19 💬
261	Lysosome 💬	[1] IDS 💬	D04499 💬	Idursulfase	[1] 19 💬
262	Lysosome 💬	[1] IDS 💬	D11025 💬	Idursulfase beta	[1] 19 💬
263	Lysosome 💬	[1] IDS 💬	D11812 💬	Pabinafusp alfa	[1] 19 💬
264	Lysosome 💬	[1] IDUA 💬	D04670 💬	Laronidase	[2] 19, 256 💬
265	Lysosome 💬	[1] LIPA 💬	D10377 💬	Sebelipase alfa	[1] 19 💬
266	Lysosome 💬	[1] MAN2B1 💬	D11024 💬	Velmanase alfa	[1] 19 💬
267	Lysosome 💬	[1] SMPD1 💬	D10820 💬	Olipudase alfa	[1] 19 💬
268	Lysosome 💬	[1] SORT1 💬	D12427 💬	Latozinemab	[2] 2 , 127 💬
269	Lysosome 💬	[1] TPP1 💬	D10813 💬	Cerliponase alfa	[1] 19 💬