18. 脊髄小脳変性症（多系統萎縮症を除く。） Spinocerebellar degeneration Clinical trials / Disease details
臨床試験数 : 76 / 薬物数 : 98 - (DrugBank : 31) / 標的遺伝子数 : 44 - 標的パスウェイ数 : 65
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT03761511 (ClinicalTrials.gov) | April 2023 | 27/11/2018 | Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicentre Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia | Friedreich Ataxia | Drug: Nicotinamide;Drug: Placebo | RWTH Aachen University | Assistance Publique - Hôpitaux de Paris | Not yet recruiting | 18 Years | N/A | All | 225 | Phase 2 | Austria;France;Germany;Italy;Spain;United Kingdom |
| 2 | NCT04192136 (ClinicalTrials.gov) | September 3, 2020 | 6/12/2019 | NAD+ and Exercise in FA | NAD+ Precursor Supplementation With Exercise Training to Increase Aerobic Capacity in Friedreich's Ataxia | Friedreich Ataxia 1 | Dietary Supplement: Nicotinamide Riboside;Dietary Supplement: Placebo;Other: Exercise Intervention | Children's Hospital of Philadelphia | National Heart, Lung, and Blood Institute (NHLBI) | Recruiting | 10 Years | 40 Years | All | 72 | N/A | United States |
| 3 | EUCTR2017-002163-17-ES (EUCTR) | 08/04/2020 | 23/01/2020 | MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. - NICOFA | Friedreich Ataxia;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: Nicotinamide INN or Proposed INN: NICOTINAMIDE | RWTH Aachen University represented by the Rector himself, represented by the Dean of the Medical Faculty | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 225 | Phase 2;Phase 3 | Spain;Austria;Germany;United Kingdom | ||
| 4 | EUCTR2017-002163-17-GB (EUCTR) | 21/01/2020 | 31/10/2019 | Use of Nicotinamide for the Treatment of Patients with Friedreich's Ataxia. | A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICH´S ATAXIA (NICOFA) - NICOFA | Friedreich's ataxia.Friedreich ataxia is the most frequent early-onset autosomal recessive hereditary ataxia. It is caused by a pathological expansion of a GAA repeat in the first intron of the frataxin gene (FXN) and results in decreased levels of FXN protein. FXN deficiency results in a relentlessly progressive neurodegenerative condition which frequently presents around puberty. Patients gradually lose coordination, become dysarthric and are frequently wheelchair-bound as adolescents. MedDRA version: 20.0;Level: PT;Classification code 10017374;Term: Friedreich's ataxia;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Nicotinamide Product Name: Nicotinamide INN or Proposed INN: Nicotinamide Other descriptive name: SUB09246MIG | RWTH Aachen University, Center for Translational & Clinical Research Aachen (CTC-A) | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 225 | Phase 2;Phase 3 | Austria;United Kingdom;Germany;Spain | ||
| 5 | EUCTR2017-002163-17-AT (EUCTR) | 04/09/2019 | 01/08/2019 | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. - NICOFA | Friedreich Ataxia;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: Nicotinamide INN or Proposed INN: NICOTINAMIDE | RWTH Aachen University represented by the Rector himself, represented by the Dean of the Medical Faculty | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 225 | Phase 2;Phase 3 | Austria;Germany | ||
| 6 | EUCTR2017-002163-17-DE (EUCTR) | 25/10/2018 | 20/11/2017 | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTRE STUDY OF THE EFFICACY AND SAFETY OF NICOTINAMIDE IN PATIENTS WITH FRIEDREICHS ATAXIA. - NICOFA | Friedreich Ataxia;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: Nicotinamide INN or Proposed INN: NICOTINAMIDE | RWTH Aachen University represented by the Center for Translational & Clinical Research Aachen (CTC-A) | NULL | Not Recruiting | Female: yes Male: yes | 225 | Phase 2;Phase 3 | Spain;Austria;Germany;United Kingdom |