206. 脆弱X症候群 Fragile X syndrome Clinical trials / Disease details
臨床試験数 : 108 / 薬物数 : 91 - (DrugBank : 36) / 標的遺伝子数 : 52 - 標的パスウェイ数 : 77
Showing 1 to 10 of 108 diseases
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
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1 | NCT05301361 (ClinicalTrials.gov) | February 1, 2023 | 8/3/2022 | Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities | Sensitivity of the NIH Toolbox Cognition Battery to Stimulant Treatment in Intellectual Disabilities Sensitivity of the NIH Toolbox Cognition Battery to Stimulant Treatment in Intellectual Disabilities ... | Intellectual Disability;Fragile X Syndrome;Down Syndrome;Attention Deficit Hyperactivity Disorder | Drug: Methylphenidate Oral Solution | University of California, Davis | NULL | Recruiting | 6 Years | 17 Years | All | 68 | Phase 1 | United States |
2 | NCT05358886 (ClinicalTrials.gov) | November 1, 2022 | 27/4/2022 | A Study of BPN14770 in Male Adults (Aged 18 to 45) With Fragile X Syndrome | A Randomized, Double-blind, Placebo-controlled, Parallel Group Study of BPN14770 in Male Adults (Aged 18 to 45) With Fragile X Syndrome A Randomized, Double-blind, Placebo-controlled, Parallel Group Study of BPN14770 in Male Adults (Age ... | Fragile X Syndrome | Drug: BPN14770/ zatolmilast;Drug: Placebo | Tetra Discovery Partners | NULL | Recruiting | 18 Years | 45 Years | Male | 150 | Phase 3 | United States |
3 | NCT05367960 (ClinicalTrials.gov) | November 1, 2022 | 29/4/2022 | An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome | An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome | Fragile X Syndrome | Drug: Zatolmilast/ BPN14770 | Tetra Discovery Partners | NULL | Enrolling by invitation | 12 Years | 45 Years | Male | 300 | Phase 3 | United States |
4 | NCT05418049 (ClinicalTrials.gov) | September 8, 2022 | 31/5/2022 | Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge | Evaluating the Neurophysiologic and Clinical Effects of Single-Dose Baclofen, Roflumilast, Memantine, and Placebo in Fragile X Syndrome Evaluating the Neurophysiologic and Clinical Effects of Single-Dose Baclofen, Roflumilast, Memantine ... | Fragile X Syndrome | Drug: Baclofen;Drug: Memantine;Drug: Roflumilast;Drug: Placebo | Children's Hospital Medical Center, Cincinnati | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Recruiting | 18 Years | 45 Years | All | 45 | Phase 2 | United States |
5 | NCT04823052 (ClinicalTrials.gov) | May 25, 2022 | 24/3/2021 | Investigation of Sulindac (HLX-0201) and Gaboxadol (HLX-0206) in Male Fragile X Syndrome Patients Aged 13-40 Investigation of Sulindac (HLX-0201) and Gaboxadol (HLX-0206) in Male Fragile X SyndromePatients Age ... | A Phase 2, Placebo-controlled, Adaptive Design Study to Explore the Safety and Efficacy of Sulindac (HLX-0201) and Gaboxadol (HLX-0206) and Possible Other Treatments in Adolescent and Adult Males With Fragile X Syndrome (FXS) A Phase 2, Placebo-controlled, Adaptive Design Study to Explore the Safety and Efficacy of Sulindac ... | Fragile X Syndrome | Drug: Sulindac (HLX-0201), dose strength 1;Drug: Sulindac (HLX-0201), dose strength 2;Drug: Placebo;Drug: Gaboxadol (HLX-0206) Drug: Sulindac(HLX-0201), dose strength 1;Drug: Sulindac(HLX-0201), dose strength 2;Drug: Placebo;Dr ... | Healx Limited | NULL | Withdrawn | 13 Years | 40 Years | Male | 0 | Phase 2 | United States;Australia |
6 | NCT05163808 (ClinicalTrials.gov) | March 29, 2022 | 15/12/2021 | A Randomized Study of BPN14770 in Male Adolescents (Aged 12 to < 18 Years) With Fragile X Syndrome | A Randomized, Double-blind, Placebo-controlled, Two-Part Study of High and Low Dose BPN14770 in Male Adolescents (Aged 12 to < 18 Years) With Fragile X Syndrome A Randomized, Double-blind, Placebo-controlled, Two-Part Study of High and Low Dose BPN14770 in Male ... | Fragile X Syndrome | Drug: zatolmilast;Drug: Placebo | Tetra Discovery Partners | NULL | Recruiting | 12 Years | 18 Years | Male | 150 | Phase 2/Phase 3 | United States |
7 | NCT05120505 (ClinicalTrials.gov) | December 29, 2021 | 3/11/2021 | Metformin in Children With Fragile X Syndrome | Efficacy and Safety of Metformin in the Treatment of Fragile X Syndrome | Fragile X Syndrome;Metformin | Drug: Metformin;Drug: Placebo | Children's Hospital of Fudan University | NULL | Recruiting | 2 Years | 16 Years | All | 20 | Phase 4 | China |
8 | NCT05030129 (ClinicalTrials.gov) | October 7, 2021 | 5/8/2021 | Single Blind Study of Ergoloid Mesylates, 5-HTP and the Combination in Adult Males With Fragile X Syndrome Single Blind Study of Ergoloid Mesylates, 5-HTP and the Combination in Adult Males With Fragile X Sy ... | An Exploratory Single Blind Study of Ergoloid Mesylates, 5-Hydroxytryptophan, and the Combination in Adult Males With Fragile X Syndrome An Exploratory Single Blind Study of Ergoloid Mesylates, 5-Hydroxytryptophan, and the Combination in ... | Fragile X Syndrome | Dietary Supplement: 5-Hydroxytryptophan / Vitamin B6;Drug: Ergoloid Mesylate;Other: Placebo | Elizabeth Berry-Kravis | NULL | Recruiting | 18 Years | 45 Years | Male | 15 | Phase 2 | United States |
9 | NCT04977986 (ClinicalTrials.gov) | September 13, 2021 | 20/7/2021 | Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome | A Randomized, Double-Blind, Placebo-Controlled, Multiple-Center, Efficacy and Safety Study of ZYN002 Administered as a Transdermal Gel to Children, Adolescents and Young Adults With Fragile X Syndrome - RECONNECT A Randomized, Double-Blind, Placebo-Controlled, Multiple-Center, Efficacy and Safety Study of ZYN002 ... | Fragile X Syndrome | Drug: ZYN002 - transdermal gel;Drug: Placebo | Zynerba Pharmaceuticals, Inc. | NULL | Recruiting | 3 Years | 23 Years | All | 204 | Phase 3 | United States;Australia;Ireland;United Kingdom |
10 | NCT04314856 (ClinicalTrials.gov) | January 12, 2021 | 11/3/2020 | Novel Clinical Target in Fragile X Syndrome | Sigma-1 Receptors: A Novel Clinical Target in Fragile X Syndrome | Fragile X Syndrome (FXS) | Drug: 18F-FTC-146 | Guido A. Davidzon, MD, SM | NULL | Withdrawn | 18 Years | 65 Years | All | 0 | Phase 1 | United States |