224. 紫斑病性腎炎 Purpura nephritis Clinical trials / Disease details
臨床試験数 : 16 / 薬物数 : 43 - (DrugBank : 21) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 58
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR2200057905 | 2022-04-01 | 2022-03-21 | A prospective, open, randomized controlled study of hydroxychloroquine sulfate in the treatment of adult Henoch Schonlein purpura nephritis | A prospective, open, randomized controlled study of hydroxychloroquine sulfate in the treatment of adult Henoch Schonlein purpura nephritis | Henoch Schonlein purpura nephritis | Experimental group:Hydroxychloroquine sulfate;Control group:Conventional therapy; | Daping Hospital, Army Medical University | NULL | Recruiting | 18 | Both | Experimental group:42;Control group:42; | Phase 4 | China | |
| 2 | ChiCTR2000040625 | 2021-01-01 | 2020-12-04 | Therapeutic effect of hydroxychloroquine on children Henoch-Schonlein purpura nephritis | Therapeutic effect of hydroxychloroquine on children Henoch-Schonlein purpura nephritis | Henoch-Schonlein purpura nephritis | A:Basic treatment + hydroxychloroquine (5mg/kg.d, taken orally in 2 doses);B:Basic treatment; | Shengjing Hospital of China Medical University | NULL | Pending | 3 | 14 | Both | A:20;B:20; | N/A | China |
| 3 | ChiCTR2000039686 | 2020-12-01 | 2020-11-05 | To evaluate the efficacy and safety of tacrolimus in the treatment of children with Henoch Schonlein purpura nephritis | A multicentre, randomized, prospective, observational study evaluating the efficacy and safety of tacrolimus in the treatment of Henoch Schonlein purpura nephritis in children at 24 weeks | Henoch Schonlein purpura nephritis | Experimental drug treatment group:Tacroximus capsule (trade name: Saifu X R), 0.1mg /kg/d, orally taken 1 hour before or 2-3 hours after meals twice a day for 24 weeks;Prednisone 1.5-2mg/kg/d was taken orally for 4 weeks and then changed to oral administration every other day for 4 weeks, gradually reducing the amount.;Control treatment group:Cyclophosphamide 8-10mg/ kg/d was given intravenously for 2 consecutive days, once every 2-4 weeks for 4 consecutive times, and once every 3 weeks for 2 consecutive times for 6 times in total.Prednisone 1.5-2mg/kg/d was taken orally with breakfast in the morning. ; | Shengjing Hospital of China Medical University | NULL | Recruiting | Both | Experimental drug treatment group:156;Control treatment group:78; | Phase 4 | China | ||
| 4 | ITMCTR2100004424 | 2020-11-06 | 2020-11-06 | A single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang Granules | A single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang Granules | Children with purpura nephritis | experimental group:Huaiqihuang;control group:valsartan; | Children's Hospital, Zhejiang University School of Medicine | NULL | Recruiting | 6 | 14 | Male | experimental group:5;control group:5; | China | |
| 5 | ChiCTR2000039700 | 2020-11-06 | 2020-11-06 | A single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang Granules | A single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang Granules | Children with purpura nephritis | experimental group:Huaiqihuang;control group:valsartan; | Children's Hospital, Zhejiang University School of Medicine | NULL | Recruiting | 6 | 14 | Male | experimental group:5;control group:5; | China | |
| 6 | NCT04623866 (ClinicalTrials.gov) | November 1, 2020 | 25/10/2020 | Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang Granules | A Single Center Randomized Controlled Clinical Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang Granules | Henoch Schönlein Purpura Nephritis | Drug: Huaiqinhuang;Drug: valsartan | The Children's Hospital of Zhejiang University School of Medicine | NULL | Not yet recruiting | 6 Years | 14 Years | All | 10 | Early Phase 1 | China |
| 7 | ChiCTR2000037540 | 2020-09-30 | 2020-08-28 | Effects and safety of MMF combined with short course steriods therapy in children Henoch-Schnlein purpura nephritis | Effects and safety of MMF combined with short course steriods therapy in children Henoch-Schnlein purpura nephritis | children Henoch-Schnlein purpura nephritis | experimental group:mycophenolate mofetil;control group:traditional course steriod; | Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine | NULL | Pending | 2 | 14 | Both | experimental group:30;control group:30; | N/A | China |
| 8 | ChiCTR1800017046 | 2018-07-15 | 2018-07-10 | The research of Gd - IgA1 with purpura nephritis | The research of Gd - IgA1 with purpura nephritis | Henoch-Schnlein purpura nephritis;D69.005+ | Gold Standard:Allergic purpura diagnostic criteria: 1) the tangibility purpura; 2) the onset age < 20 years old; 3) with acute abdominal pain; 4) biopsy showed small veins and arteries around a neutrophil infiltration. In the above four standard, conform to article 2 or above can be diagnosed as allergic purpura. Purpur;Index test:Gd-IgA1, IgA, IgG, C3; | College of Pediatrics, University of South China/Children's Hospital of Hu'nan Province | NULL | Recruiting | 1 | 14 | Both | Target condition:250;Difficult condition:24 | China | |
| 9 | NCT02878018 (ClinicalTrials.gov) | September 2016 | 17/8/2016 | Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis | Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis | Henoch-Schonlein Purpura Nephritis | Drug: Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;Drug: angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant | Liaoning University of Traditional Chinese Medicine | First Hospital of China Medical University;Shengjing Hospital | Active, not recruiting | 5 Years | 18 Years | All | 600 | China | |
| 10 | ChiCTR2200055323 | 2016-08-01 | 2022-01-07 | Efficacy and safety of tacrolimus in the treatment of children with allergic purpura nephritis | Efficacy and safety of tacrolimus in the treatment of children with allergic purpura nephritis | Allergic purpuric nephritis in children | Tacrolimus group:Tacrolimus;Cyclophosphamide group:Cyclophosphamide;Mycophenolate mofetil group:Mycophenolate mofetil; | Lanzhou University Second Hospital | NULL | Completed | 4 | 18 | Both | Tacrolimus group:31;Cyclophosphamide group:31;Mycophenolate mofetil group:30; | Phase 4 | China |
| 11 | ChiCTR-IPC-16008619 | 2016-07-01 | 2016-06-09 | Efficacy of Mizoribine for Children with Henoch-Schnlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in China | Efficacy of Mizoribine for Children with Henoch-Schnlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in China | Children with Henoch-Sch?nlein Purpura Nephritis | mizoribine:5 mg/kg body weight daily (maximum total dose: 150 mg); | Nanjing General Hospital of Nanjing Military Command | NULL | Pending | 5 | 18 | Both | mizoribine:180; | China | |
| 12 | NCT03222687 (ClinicalTrials.gov) | September 1, 2015 | 7/7/2017 | Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis | Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety | Henoch-Schönlein Purpura Nephritis | Drug: tacrolimus;Drug: prednisone | Shandong University | NULL | Completed | N/A | 18 Years | All | 25 | Phase 4 | NULL |
| 13 | NCT02532790 (ClinicalTrials.gov) | August 2015 | 20/8/2015 | The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children | The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis With Mild Proteinuria in Children | Henoch-Schoenlein Purpura Nephritis | Drug: Prednisone;Drug: ACEI | Nanjing Children's Hospital | NULL | Recruiting | 2 Years | 16 Years | All | 100 | Phase 2 | China |
| 14 | NCT02532777 (ClinicalTrials.gov) | August 2015 | 20/8/2015 | The Research of Standard Diagnosis and Treatment for HSPN in Children | The Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis in Children | Henoch-Schoenlein Purpura Nephritis | Drug: Prednisone;Drug: Cyclophosphamide(CTX);Drug: Mycophenolate mofetil(MMF);Drug: Leflunomide(LEF);Drug: Angiotensin-converting enzyme inhibitor(ACEI);Drug: Methylprednisolone | Nanjing Children's Hospital | NULL | Recruiting | 2 Years | 16 Years | All | 100 | Phase 2 | China |
| 15 | NCT03591471 (ClinicalTrials.gov) | September 2014 | 9/12/2014 | Study on Children Henoch-Schönlein Purpura Nephritis With TCM Multistep Treatment | Demonstrated Study on Children Henoch-Schönlein Purpura Nephritis With Multistep Treatment of Traditional Chinese Medicine Combined Disease and Syndrome Differentiation | Henoch-Schönlein Purpura Nephritis | Drug: Glycosides Of Tripterygium Wilfordii Hook(GTW);Drug: Sulfotanshinone Sodium Injection;Drug: Chinese herbs based on syndrome differentiation;Drug: Prednisone Acetate Tablets;Drug: Benazepril Hydrochloride Tablets;Drug: Low Molecular Weight Heparin Calcium Injection;Drug: Dipyridamole Tab 25 MG;Drug: Chinese medicine placebo | Henan University of Traditional Chinese Medicine | Peking University First Hospital;Children's Hospital of Fudan University;Shanghai Children's Hospital;Chengdu University of Traditional Chinese Medicine;Affiliated Hospital of Yunnan University of Traditional Chinese Medicine | Unknown status | 2 Years | 18 Years | All | 500 | Phase 1/Phase 2 | China |
| 16 | NCT00301613 (ClinicalTrials.gov) | January 2003 | 10/3/2006 | Mycophenolate Mofetil (MMF) Versus Intravenous CTX Pulses in the Treatment of Adult Severe HSPN | MMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura Nephritis | Henoch-Schoenlein Purpura;Nephritis | Drug: Mycophenolate mofetil | Nanjing University School of Medicine | NULL | Completed | 16 Years | 50 Years | Both | 60 | N/A | China |