254. ポルフィリン症 Porphyria Clinical trials / Disease details

臨床試験数 : 72 / 薬物数 : 53 - (DrugBank : 16) / 標的遺伝子数 : 19 - 標的パスウェイ数 : 35

20 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCT2071200074	02/02/2021	24/12/2020	Expanded Access Protocol of Givosiran for Patients with Acute Hepatic Porphyria	Expanded Access Protocol of Givosiran for Patients with Acute Hepatic Porphyria (AHP)	Acute hepatic porphyria (AHP)	Patients will be administered givosiran 2.5 mg/kg as a subcutaneous (SC) injection once monthly.	Fujii Norihisa	NULL	Complete	>= 12age old	Not applicable	Both	10	N/A	Japan
2	EUCTR2017-002432-17-NL (EUCTR)	21/06/2018	19/02/2018	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Switzerland;Italy;France;Czech Republic;Mexico;Can ...
3	EUCTR2017-002432-17-FI (EUCTR)	21/05/2018	30/11/2017	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Italy;France;Czech Republic;Mexico;Canada;Belgium; ...
4	NCT03505853 (ClinicalTrials.gov)	April 26, 2018	13/4/2018	A Study to Investigate the Interaction Between Givosiranand a 5-probe Drug Cocktail in Patients With ...	A Drug-Drug Interaction Study to Investigate the Effect of Givosiranon the Pharmacokinetics (PK) of ...	Acute Intermittent Porphyria (AIP);Acute Hepatic Porphyria (AHP);Porphyria, Acute Intermittent;Acute ...	Drug: Givosiran;Drug: 5-probe cocktail	Alnylam Pharmaceuticals	NULL	Completed	18 Years	65 Years	All	10	Phase 1	Sweden
5	EUCTR2017-002432-17-PL (EUCTR)	12/04/2018	16/01/2018	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Czechia;Taiwan;Finland;Spain;United Kingdom;Switzerland;Italy;France;Czech Republic;Me ...
6	EUCTR2017-002432-17-IT (EUCTR)	19/02/2018	02/02/2021	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519	ALNYLAM PHARMACEUTICALS, INC.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Czechia;Taiwan;Finland;Spain;United Kingdom;Switzerland;Italy;France;Czech Republic;Me ...
7	EUCTR2017-002432-17-BG (EUCTR)	19/02/2018	09/11/2017	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 24.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Italy;France;Czech Republic;Mexico;Canada;Belgium; ...
8	EUCTR2017-002432-17-DE (EUCTR)	03/01/2018	04/10/2017	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Switzerland;Italy;France;Czech Republic;Mexico;Can ...
9	EUCTR2017-002432-17-BE (EUCTR)	29/12/2017	19/12/2017	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Switzerland;Italy;France;Czech Republic;Mexico;Can ...
10	EUCTR2017-002432-17-SE (EUCTR)	21/12/2017	07/11/2017	Study on an Investigational Drug, Givosiran, for the Treatment of Acute Hepatic Porphyrias	ENVISION: A Phase 3 Randomized, Double-blind, Placebo-controlled Multicenter Study with an Open-labe ...	Acute Hepatic Porphyrias (AHP) MedDRA version: 20.0;Level: PT;Classification code 10036182;Term: Por ...	Product Name: Givosiran Product Code: ALN-AS1 INN or Proposed INN: ALN-60519 Other descriptive name: CA ...	Alnylam Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	74	Phase 3	United States;Taiwan;Finland;Spain;United Kingdom;Italy;France;Czech Republic;Mexico;Canada;Belgium; ...

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