28. 全身性アミロイドーシス Systemic amyloidosis Clinical trials / Disease details

臨床試験数 : 267 / 薬物数 : 241 - (DrugBank : 77) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 180

30 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05486481 (ClinicalTrials.gov)	April 1, 2023	1/8/2022	Venetoclax, Daratumumab, and Dexamethasone for Systemic Light-Chain Amyloidosis With Translocation ( ...	A Multicenter Phase 1/2 Study of Venetoclax / Daratumumab/ Dexamethasone for Previously Treated Syst ...	AL Amyloidosis;Light Chain (AL) Amyloidosis;Systemic Light Chain Disease	Drug: Venetoclax;Drug: Dexamethasone;Drug: Daratumumab	Sandy Wong, MD	Janssen Pharmaceuticals;AbbVie	Not yet recruiting	18 Years	N/A	All	78	Phase 1/Phase 2	United States
2	NCT05451771 (ClinicalTrials.gov)	October 26, 2022	6/7/2022	Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosis	An Open-label Phase I/II Trial of Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Sy ...	AL Amyloidosis	Drug: Venetoclax Oral Tablet, 200 mg;Device: FISH assay;Drug: Venetoclax Oral Tablet, 400 mg;Drug: Dex ...	Rajshekhar Chakraborty, MD	Genentech, Inc.	Recruiting	18 Years	N/A	All	53	Phase 1/Phase 2	United States
3	EUCTR2021-002639-48-DE (EUCTR)	25/07/2022	15/12/2021	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	Amyloid Light Chain Amyloidosis MedDRA version: 23.0;Level: LLT;Classification code 10083938;Term: A ...	Trade Name: DAZARLEX Product Name: Daratumumab co-formulated with recombinant human hyaluronidase (rHu ...	Janssen-Cilag International N.V.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	150	Phase 2	France;United States;Greece;Canada;Spain;Netherlands;Germany;United Kingdom;Italy
4	EUCTR2021-002639-48-NL (EUCTR)	10/06/2022	09/02/2022	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	Amyloid Light Chain Amyloidosis MedDRA version: 23.0;Level: LLT;Classification code 10083938;Term: A ...	Trade Name: DAZARLEX Product Name: Daratumumab co-formulated with recombinant human hyaluronidase (rHu ...	Janssen-Cilag International N.V.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	150	Phase 2	United States;France;Greece;Canada;Spain;Germany;Netherlands;United Kingdom;Italy
5	EUCTR2021-002639-48-ES (EUCTR)	08/03/2022	28/12/2021	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain ...	Amyloid Light Chain Amyloidosis MedDRA version: 23.0;Level: LLT;Classification code 10083938;Term: A ...	Trade Name: DAZARLEX Product Name: Daratumumab co-formulated with recombinant human hyaluronidase (rHu ...	Janssen-Cilag International N.V.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	150	Phase 2	France;United States;Greece;Canada;Spain;Netherlands;Germany;United Kingdom;Italy
6	NCT04270175 (ClinicalTrials.gov)	April 14, 2021	12/2/2020	Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Pa ...	Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Pa ...	Amyloid;AL Amyloidosis;Refractory AL Amyloidosis	Drug: Daratumumab;Drug: Pomalidomide;Drug: Dexamethasone	Weill Medical College of Cornell University	Janssen Scientific Affairs, LLC	Recruiting	18 Years	N/A	All	21	Phase 2	United States
7	EUCTR2019-001962-13-IT (EUCTR)	13/01/2021	21/10/2020	Daratumumab and Pomalidomide in previously treated patients with AL amyloidosis	A multi-center open label phase II study of daratumumaband pomalidomide in previously treated patien ...	AL amyloidosis MedDRA version: 20.0;Level: PT;Classification code 10002022;Term: Amyloidosis;System ...	Trade Name: Imnovid Product Name: Pomalidomide Product Code: [Pomalidomide] INN or Proposed INN: pomali ...	FONDAZIONE I.R.C.C.S. POLICLINICO SAN MATTEO	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	40	Phase 2	Italy
8	NCT04304144 (ClinicalTrials.gov)	March 18, 2020	28/2/2020	A Study to Evaluate the Safety and Tolerability of CAEL-101 in Patients With AL Amyloidosis	CAEL101-203: A Phase 2, Open-label, Multicenter Dose Selection Study to Evaluate the Safety and Tole ...	AL Amyloidosis	Drug: CAEL-101;Drug: SoC: cyclophosphamide, bortezomib, and Dexamethasone (CyBorD);Drug: Daratumumab ...	Alexion Pharmaceuticals	NULL	Active, not recruiting	18 Years	N/A	All	25	Phase 2	United States
9	EUCTR2018-004333-33-FR (EUCTR)	23/01/2020	02/12/2019	Phase 2 study of daratumumabmonotherapy in previously untreated patients with stage 3B light chain ( ...	Phase 2 study of daratumumabmonotherapy in previously untreated patients with stage 3B light chain ( ...	Patients with newly diagnosed stage 3B AL amyloidosis MedDRA version: 20.0;Level: PT;Classification ...	Trade Name: Velcade Product Name: Bortezomib Product Code: 26866138 INN or Proposed INN: BORTEZOMIB Prod ...	European Myeloma Network	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	40	Phase 2	France;Greece;Netherlands;Italy
10	EUCTR2018-004333-33-IT (EUCTR)	01/08/2019	28/04/2020	Phase 2 study of daratumumabmonotherapy in previously untreated patients with stage 3B light chain ( ...	Phase 2 study of daratumumabmonotherapy in previously untreated patients with stage 3B light chain ( ...	Patients with newly diagnosed stage 3B AL amyloidosis MedDRA version: 20.0;Level: PT;Classification ...	Trade Name: Darzalex Product Name: Daratumumab Product Code: JNJ-54767414 INN or Proposed INN: DARATUMU ...	European Myeloma Network	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	40	Phase 2	France;Greece;Netherlands;Italy

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