46. 悪性関節リウマチ Malignant rheumatoid arthritis Clinical trials / Disease details

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

35 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCT2071210132	23/03/2022	09/03/2022	A single dose study in healthy Japanese participants to evaluate the safety and pharmacokinetics of ...	A single center, single dose, open-label study in healthy Japanese participants to evaluate the safe ...	Rheumatoid Arthritis	Single subcutaneous dose of otilimab	Yamada Masanori	NULL	Pending	>= 20age old	<= 50age old	Both	12	Phase 1	Japan
2	EUCTR2019-000878-30-DE (EUCTR)	18/01/2021	28/05/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	3000	Phase 3	Serbia;United States;Philippines;Estonia;Spain;Thailand;Ukraine;Russian Federation;Colombia;Italy;In ...
3	EUCTR2019-000878-30-BE (EUCTR)	18/11/2020	21/09/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	3000	Phase 3	Serbia;United States;Philippines;Estonia;Spain;Thailand;Ukraine;Russian Federation;Colombia;Italy;In ...
4	EUCTR2019-000878-30-LV (EUCTR)	29/10/2020	30/07/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 21.0;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: ...	GlaxoSmithKline Research & Development Limited	NULL	Not Recruiting			Female: yes Male: yes	3000	Phase 3	United States;Serbia;Philippines;Estonia;Thailand;Spain;Ukraine;Russian Federation;Colombia;Italy;In ...
5	EUCTR2019-000878-30-BG (EUCTR)	04/09/2020	11/08/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	3000	Phase 3	Serbia;United States;Philippines;Estonia;Spain;Thailand;Ukraine;Russian Federation;Colombia;Italy;In ...
6	NCT04333147 (ClinicalTrials.gov)	May 12, 2020	27/3/2020	Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA) ...	A Multi-centre Long-term Extension Study to Assess the Safety and Efficacy of GSK3196165 in the Trea ...	Arthritis, Rheumatoid	Biological: Otilimab (GSK3196165);Drug: csDMARD(s)	GlaxoSmithKline	Iqvia Pty Ltd	Active, not recruiting	18 Years	N/A	All	2916	Phase 3	United States;Argentina;Australia;Belgium;Bulgaria;Canada;China;Colombia;Czechia;Estonia;Germany;Hun ...
7	EUCTR2019-000867-26-DE (EUCTR)	08/04/2020	04/07/2019	Efficacy and safety study, comparing GSK3196165 (study drug) with placebo and with tofacitinib in co ...	A 52-week, phase 3, multicentre, randomised, double blind, efficacy and safety study, comparing GSK3 ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK3196165 INN or Proposed INN: OTILIMAB Other descriptive name: A ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1800	Phase 3	United States;Estonia;Spain;Thailand;Russian Federation;Colombia;United Kingdom;France;Hungary;Mexic ...
8	EUCTR2019-000878-30-HU (EUCTR)	26/03/2020	28/02/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 21.0;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: Anti human granulocyte ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	3000	Phase 3	Japan;Serbia;United States;Philippines;Estonia;Thailand;Spain;Ukraine;Russian Federation;Colombia;It ...
9	EUCTR2019-000868-18-DE (EUCTR)	13/03/2020	08/07/2019	Efficacy and safety of GSK3196165 versus placebo and sarilumab in participants with moderately to se ...	A 24-week, phase 3, multicentre, randomised, double-blind, efficacy and safety study, comparing GSK3 ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK3196165 INN or Proposed INN: OTILIMAB Other descriptive name: A ...	GlaxoSmithKline Research & Development Limited	NULL	Not Recruiting			Female: yes Male: yes	600	Phase 3	United States;Czechia;Spain;Lithuania;United Kingdom;Italy;Czech Republic;Hungary;Canada;Argentina;B ...
10	EUCTR2019-000878-30-CZ (EUCTR)	26/02/2020	06/01/2020	A long-term extension study to assess the safety and efficacy of GSK3196165 in the treatment of rheu ...	A multi-centre long-term extension study to assess the safety and efficacy of GSK3196165 in the trea ...	Rheumatoid Arthritis MedDRA version: 23.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: otilimab Product Code: GSK 3196165 INN or Proposed INN: OTILIMAB Other descriptive name: ...	GlaxoSmithKline Research & Development Limited	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	3000	Phase 3	Serbia;United States;Philippines;Estonia;Spain;Thailand;Ukraine;Russian Federation;Colombia;Italy;In ...

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