47. バージャー病 Buerger disease Clinical trials / Disease details


臨床試験数 : 9 薬物数 : 14 - (DrugBank : 7) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 16

  
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1NCT05698979
(ClinicalTrials.gov)
January 30, 20235/1/2023Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's DiseaseEvaluation of Botulinum TOXin Type A in the Treatment of Buerger's DiseaseBuerger Disease;Raynaud SyndromeDrug: BOTOX INJECTIONUniversity Hospital, ToulouseNULLNot yet recruiting18 YearsN/AAll8Phase 3NULL
2ChiCTR2100048104
2021-08-012021-07-01A clinical study of safety and efficacy of transcatheter intra-arterial infusion of extract of Ginkgo biloba leaves injection in the treatment of sever limb ischemia in patients with Thromboangiitis ObliteransA clinical study of safety and efficacy of transcatheter intra-arterial infusion of extract of Ginkgo biloba leaves injection in the treatment of sever limb ischemia in patients with Thromboangiitis Obliterans Thromboangiitis ObliteransTreatment group:Transcatheter intra-arterial infusion of Ginkgo biloba leaves injection;Control group:Transcatheter intra-arterial infusion of heparin sodium injection;First Clinical Center of Chinese PLA General HospitalNULLPending50BothTreatment group:30;Control group:30;China
3NCT02501018
(ClinicalTrials.gov)
November 1, 201714/7/2015Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI)A Prospective, Open Label, Controlled, Randomized, Multicenter Study to Assess the Efficacy and Safety of CLBS12 in Patients With Critical Limb Ischemia (CLI) Due to Arteriosclerosis Obliterans (ASO) With a Single-arm Substudy to Assess the Safety and Potential Efficacy of CLBS12 in Patients With CLI Due to Buerger's Disease (BD)Critical Limb Ischemia;Buerger Disease;Thromboangiitis Obliterans;Atherosclerosis ObliteransBiological: CLBS12;Drug: SOCLisata Therapeutics, Inc.NULLCompleted20 Years85 YearsAll33Phase 2Japan
4NCT03056742
(ClinicalTrials.gov)
February 20, 201723/1/2017A Clinical Trial to Study the Efficacy and Safety of Stempeucel® in Patients With CLI Due to Buergers DiseaseA Single Arm, Open Label, Multicentric, Clinical Study Assessing the Efficacy and Safety of Stempeucel® (ex Vivo Cultured Adult Bone Marrow Derived Allogeneic Mesenchymal Stem Cells) in Patients With CLI Due to Buerger's DiseaseCritical Limb Ischemia Due to Buerger's DiseaseBiological: Stempeucel(R)Stempeutics Research Pvt LtdNULLWithdrawn18 Years65 YearsAll0Phase 2India
5JPRN-UMIN000021374
2016/03/0707/03/2016Ex Vivo Expanded Erythroblast-Transplantation for patient with critical limb ischemiaEx Vivo Expanded Erythroblast-Transplantation for patient with critical limb ischemia - EVEETA study Peripheral Arterial Disease (PAD) , Buerger disease, and arteritis associated with collagen diseases (Fontaines stage: III and IV)1)Autologous Bone Marrow Collection: 40 to 60 ml of bone marrow is collected from iliaccrest under local anaesthesia 14 days before the implantation.
2)Ex vivo expanded immature erythroblasts from autologous bone marrow cells : All procedures are enforced by exclusive
technical exparts along the approved protocols in GMP-grade Cell Processing Room established in Bioscience Medical Research Center, Niigata University Medical and Dental Hospital. Mononuclear cells separated from the bone marrow are incubated in a suspension culture in the presence of rh Flt-ligand, rh SCF, rh Thrombopoietin, and culture supplements for 7 days to expand myeloid progenitors. Harvested and washed cells are further cultured in the presence of rh SCF, rh IGF-I, rh Erythropoietin, and culture supplements for additional 7 days to expand immature erythroblasts and macrophages. Cultured cells are finally harvested, washed, suspended in 50 ml of autologous platelet rich plasma, and transferred from the bio clean room to bedside.
3)Transplantation of cultured cell: Aliquots of the 50 ml of cell suspension are intramuscularly injected in 100 points of the ischaemic limb. Daily intramuscular injection of 6000 IU of rh erythropoietin in the same loci follows from day 0 for consecutive 5 days.
EVEETA Study GroupNULLComplete: follow-up complete20years-old80years-oldMale and Female11Not selectedJapan
6NCT01484574
(ClinicalTrials.gov)
January 201227/11/2011A Clinical Trial to Study the Efficacy and Safety of Different Doses of Bone Marrow Derived Mesenchymal Stem Cells in Patients With Critical Limb Ischemia Due to Buergers DiseaseA Non-randomized, Open Label, Multicentric, Dose Ranging , Phase II Study Assessing the Efficacy and Safety of Intramuscular Administration of Stempeucel - CLI™ (ex Vivo Cultured Adult Bone Marrow Derived Allogeneic Mesenchymal Stem Cells) in Patients With Critical Limb Ischemia Due to Buerger's DiseaseCritical Limb Ischemia;Buerger's DiseaseBiological: Allogeneic Mesenchymal Stem CellsStempeutics Research Pvt LtdNULLCompleted18 Years65 YearsBoth90Phase 2India
7JPRN-UMIN000005227
2011/03/0109/03/2011Transplantation of autologous and G-CSF mobilized mononuclear cells in patients with critical limb ischemia (CLI)Transplantation of autologous and G-CSF mobilized mononuclear cells in patients with critical limb ischemia (CLI) - G-CSF mobilized MNC therapy in CLI patients CLI (Atherosclerotic PAD/Buerger disease )Subcutaneous administration of G-CSF, Harvest and implantation of PB-MNCRegenerative Medicine Unit, Division of Vascular Regeneration Therapy, Institute of Biomedical Research and Innovation (IBRI)NULLComplete: follow-up complete20years-old80years-oldMale and Female5Not selectedJapan
8NCT01447550
(ClinicalTrials.gov)
January 20095/10/2011Treatment of Thromboangiitis Obliterans (Buerguer's Disease) With BosentanTreatment of Thromboangiitis Obliterans (Buerger's Disease) With BosentanThromboangiitis ObliteransDrug: BosentanHospital Universitario GetafeNULLCompleted18 Years65 YearsBoth12N/ASpain
9NCT01302015
(ClinicalTrials.gov)
December 200717/2/2011Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's DiseaseSafety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's DiseaseBuerger's DiseaseBiological: RNL-Vascostem®R-BioNULLCompleted20 Years80 YearsAll15N/AKorea, Republic of