51. 全身性強皮症 Scleroderma Clinical trials / Disease details

臨床試験数 : 525 / 薬物数 : 565 - (DrugBank : 148) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 217

23 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05298358 (ClinicalTrials.gov)	November 18, 2022	7/3/2022	RIC alloBMT With Post-transplant Cyclophosphamide for Refractory Systemic Sclerosis	A Phase I Study of Reduced Intensity Conditioning Allogeneic Bone Marrow Transplant With Post-transp ...	Systemic Sclerosis	Biological: RIC alloBMT w PTCy in refractory SSc	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	NULL	Recruiting	18 Years	65 Years	All	30	Phase 1	United States
2	NCT04380831 (ClinicalTrials.gov)	February 24, 2022	30/4/2020	TBI Using IMRT and CyclophosphamidePrior to Stem Cell Transplant for the Treatment of Severe Systemi ...	Pilot Study of Total Body Irradiation Using Intensity Modulated Radiation Therapy (IMRT) and Cycloph ...	Systemic Scleroderma	Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;Drug: Cyclophosphamide;Radiation: Inte ...	City of Hope Medical Center	National Cancer Institute (NCI)	Recruiting	18 Years	65 Years	All	15	Early Phase 1	United States
3	JPRN-jRCTc071190041	04/01/2019	09/01/2020	A clinical trial of autologous stem cell transplantation for severe systemic sclerosis	A single-arm, open-label, phase 2 study of autologous CD34+ stem cells-selected transplantation for ...	systemic sclerosis	After peripheral blood stem cell mobilization and aphereisi with cyclophosphamide4 g/m2 and G-CSF, C ...	Akashi Koichi	NULL	Not Recruiting	>= 16age old	< 65age old	Both	12	Phase 2	Japan
4	NCT03630211 (ClinicalTrials.gov)	July 31, 2018	7/8/2018	Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis	Autologous Stem Cell Transplantation With CD34-Selected Peripheral Blood Stem Cells (PBSC) in Patien ...	Systemic Sclerosis;Diffuse Sclerosis Systemic;Interstitial Lung Disease;Pulmonary Hypertension	Drug: Cyclophosphamide;Drug: Mesna;Drug: Rituximab;Drug: Alemtuzumab;Drug: Thiotepa;Drug: GM-CSF;Dru ...	Paul Szabolcs	NULL	Recruiting	8 Years	60 Years	All	8	Phase 2	United States
5	NCT03593902 (ClinicalTrials.gov)	May 17, 2018	28/6/2018	Cardiac Safe Transplants for Systemic Sclerosis	Autologous Hematopoietic Stem Cell Transplant for Patients With Systemic Sclerosis and Cardiac Dysfu ...	Systemic Sclerosis;Scleroderma	Drug: Rituximab;Drug: Fludarabine;Drug: Cyclophosphamide;Drug: Mesna;Drug: rATG;Drug: Methylpredniso ...	Northwestern University	NULL	Terminated	18 Years	65 Years	All	9	Phase 2/Phase 3	United States
6	NCT01862926 (ClinicalTrials.gov)	November 2014	22/5/2013	Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD	A Randomized, Double Blind Controlled Trial Comparing Rituximab Against Intravenous Cyclophosphamide ...	Interstitial Lung Disease;Scleroderma;Idiopathic Inflammatory Myositis;Mixed Connective Tissue Disea ...	Drug: Rituximab;Drug: Cyclophosphamide	Royal Brompton & Harefield NHS Foundation Trust	Imperial College London;University of East Anglia;University College London Hospitals	Completed	18 Years	80 Years	All	104	Phase 2/Phase 3	United Kingdom
7	EUCTR2012-003633-42-GB (EUCTR)	18/10/2013	22/08/2013	A trial of rituximab compared to usual best care in patients with interstitial (inflammatory or scar ...	A randomized, double blind controlled trial comparing rituximab against intravenous cyclophosphamide ...	A diagnosis of connective tissue disease associated interstitial lung disease, based on internationa ...	Trade Name: MabThera Product Name: Rituximab INN or Proposed INN: Rituximab Trade Name: Cyclophosphamid ...	Royal Brompton and Harefield NHS Foundation Trust	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			United Kingdom
8	NCT01570764 (ClinicalTrials.gov)	January 14, 2013	2/4/2012	Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease	Intravenous Cyclophosphamidefor the Treatment of Systemic Sclerosis Associated Interstitial Lung Dis ...	Systemic Sclerosis;Scleroderma;Interstitial Lung Disease;Lung Fibrosis	Drug: Cyclophosphamide;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	Hôpital Claude-Huriez	Completed	18 Years	N/A	All	40	Phase 3	France
9	NCT01445821 (ClinicalTrials.gov)	September 15, 2011	29/9/2011	Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial	Randomized Study of Different Non-myeloablative Conditioning Regimens With Hematopoietic Stem Cell S ...	Scleroderma, Systemic	Biological: Peripheral Blood Stem Cells;Drug: Cyclophosphamide;Drug: Mesna;Drug: rATG;Drug: Methylpr ...	Northwestern University	NULL	Terminated	17 Years	60 Years	All	44	Phase 3	United States
10	JPRN-UMIN000031940	2010/09/07	28/03/2018	Phase 2 trial of autologous hematopoietic stem cell transplantation for severe systemic sclerosis	Phase 2 trial of autologous hematopoietic stem cell transplantation for severe systemic sclerosis - ...	Systemic sclerosis	Cyclophosphamide2g/m2, 2 days Harvest of autologous hematopoietic stem cells Cyclophosphamide50mg/kg ...	Kyushu University	NULL	Complete: follow-up complete	16years-old	65years-old	Male and Female	24	Phase 2	Japan

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