51. 全身性強皮症 Scleroderma Clinical trials / Disease details

臨床試験数 : 525 / 薬物数 : 565 - (DrugBank : 148) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 217

18 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03844061 (ClinicalTrials.gov)	July 29, 2019	31/1/2019	Belimumab and RituximabCombination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis ...	A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and RituximabCombination Therapy f ...	Systemic Sclerosis	Drug: Belimumab;Drug: Rituximab;Other: Placebo Subcutaneous Injection;Other: Placebo Infusion;Drug: ...	Hospital for Special Surgery, New York	GlaxoSmithKline	Recruiting	18 Years	80 Years	All	30	Phase 2	United States
2	NCT03630211 (ClinicalTrials.gov)	July 31, 2018	7/8/2018	Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis	Autologous Stem Cell Transplantation With CD34-Selected Peripheral Blood Stem Cells (PBSC) in Patien ...	Systemic Sclerosis;Diffuse Sclerosis Systemic;Interstitial Lung Disease;Pulmonary Hypertension	Drug: Cyclophosphamide;Drug: Mesna;Drug: Rituximab;Drug: Alemtuzumab;Drug: Thiotepa;Drug: GM-CSF;Dru ...	Paul Szabolcs	NULL	Recruiting	8 Years	60 Years	All	8	Phase 2	United States
3	NCT03593902 (ClinicalTrials.gov)	May 17, 2018	28/6/2018	Cardiac Safe Transplants for Systemic Sclerosis	Autologous Hematopoietic Stem Cell Transplant for Patients With Systemic Sclerosis and Cardiac Dysfu ...	Systemic Sclerosis;Scleroderma	Drug: Rituximab;Drug: Fludarabine;Drug: Cyclophosphamide;Drug: Mesna;Drug: rATG;Drug: Methylpredniso ...	Northwestern University	NULL	Terminated	18 Years	65 Years	All	9	Phase 2/Phase 3	United States
4	NCT04274257 (ClinicalTrials.gov)	December 4, 2017	13/2/2020	A Study of the Efficacy and Safety of Rituximab in Participants With Systemic Sclerosis	Double-Blind, Parallel-group Comparison, Investigators Initiated Phase II Clinical Trial of IDEC-C2B ...	Scleroderma, Systemic;Skin Sclerosis;Lung Fibrosis;Autoimmune Diseases;Collagen Diseases	Drug: Double-Blind Placebo;Drug: Double-Blind Rituximab	Tokyo University	Japan Agency for Medical Research and Development;Zenyaku Kogyo Co., Ltd.	Completed	20 Years	80 Years	All	56	Phase 2/Phase 3	Japan
5	JPRN-UMIN000018376	2015/07/22	22/07/2015	Efficacy and safety of rituximab for patients with severe rheumatic disease	Efficacy and safety of rituximabfor patients with severe rheumatic disease - Efficacy and safety of ...	Childhood-onset severe rheumatic disease(systemic lupus erhythematosus, dermatomyositis, poly myosit ...	1) Induction Therapy rituximab375mg/m2 (max500mg) 1-4 times/1-2 weeks 2) Maintenance Therapy rituximab37 ...	Yokohama City University Hospital Department of Pediatrics	NULL	Complete: follow-up complete	2years-old	Not applicable	Male and Female	20	Not selected	Japan
6	NCT01862926 (ClinicalTrials.gov)	November 2014	22/5/2013	Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD	A Randomized, Double Blind Controlled Trial Comparing RituximabAgainst Intravenous Cyclophosphamide ...	Interstitial Lung Disease;Scleroderma;Idiopathic Inflammatory Myositis;Mixed Connective Tissue Disea ...	Drug: Rituximab;Drug: Cyclophosphamide	Royal Brompton & Harefield NHS Foundation Trust	Imperial College London;University of East Anglia;University College London Hospitals	Completed	18 Years	80 Years	All	104	Phase 2/Phase 3	United Kingdom
7	EUCTR2012-003633-42-GB (EUCTR)	18/10/2013	22/08/2013	A trial of rituximabcompared to usual best care in patients with interstitial (inflammatory or scarr ...	A randomized, double blind controlled trial comparing rituximabagainst intravenous cyclophosphamide ...	A diagnosis of connective tissue disease associated interstitial lung disease, based on internationa ...	Trade Name: MabThera Product Name: Rituximab INN or Proposed INN: Rituximab Trade Name: Cyclophosphamid ...	Royal Brompton and Harefield NHS Foundation Trust	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			United Kingdom
8	EUCTR2012-004955-35-IT (EUCTR)	29/07/2013	30/05/2013	A single-center randomized double-blind placebo-controlled trial Treatment of Systemic Sclerosis wit ...	A single-center randomized double-blind placebo-controlled trial Treatment of Systemic Sclerosis wit ...	SYSTEMIC SCLEROSIS MedDRA version: 16.0;Level: PT;Classification code 10042953;Term: Systemic sclero ...	Trade Name: Mabthera	POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Italy
9	NCT01748084 (ClinicalTrials.gov)	April 9, 2013	10/12/2012	Rituximab in Systemic Sclerosis	Evaluation of Rituximab in Systemic Sclerosis Associated Polyarthritis	Systemic Sclerosis	Drug: Rituximab;Drug: Placebo (NaCl)	Assistance Publique - Hôpitaux de Paris	NULL	Completed	18 Years	80 Years	All	22	Phase 2/Phase 3	France
10	JPRN-jRCTs031180373	14/05/2012	18/03/2019	Clinical trial of rituximab in interstitial lung disease secondary to systemic sclerosis	Clinical trial of rituximabin interstitial lung disease secondary to systemic sclerosis - Clinical t ...	Interstitial lung disease secondary to systemic sclerosis	Rituximab 375mg/m2 once a week/4 times	Yoshizaki Ayumi	Sato Shinichi	Complete	>= 20age old	< 80age old	Both	60	Phase 2	Japan

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