62. 発作性夜間ヘモグロビン尿症 Paroxysmal nocturnal hemoglobinuria Clinical trials / Disease details

臨床試験数 : 292 / 薬物数 : 151 - (DrugBank : 49) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 108

14 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05744921 (ClinicalTrials.gov)	March 9, 2023	6/2/2023	A Study to Examine the Long-term Safety, Tolerability, and Effectiveness of Pozelimaband Cemdisiran ...	An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Pozeli ...	Paroxysmal Nocturnal Hemoglobinuria	Drug: Pozelimab;Drug: Cemdisiran	Regeneron Pharmaceuticals	NULL	Not yet recruiting	18 Years	N/A	All	300	Phase 3	NULL
2	EUCTR2021-004931-10-GR (EUCTR)	04/01/2023	22/11/2022	A study to examine the long-term safety, tolerability, and effectiveness of Pozelimaband Cemdisiran ...	An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Pozeli ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	288	Phase 3	United States;Philippines;Taiwan;Greece;Thailand;Spain;Colombia;Italy;India;France;Jordan;Malaysia;P ...
3	EUCTR2020-002761-33-FR (EUCTR)	06/12/2022	21/03/2022	Efficacy and Safety of the Combination of Pozelimaband Cemdisiran versus continued Eculizumab or Rav ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
4	NCT05131204 (ClinicalTrials.gov)	October 6, 2022	12/11/2021	Efficacy and Safety of the Combination of Pozelimaband Cemdisiran Versus Continued Eculizumab or Rav ...	A Randomized, Open-Label, Eculizumab and Ravulizumab Controlled Study to Evaluate the Efficacy and S ...	Paroxysmal Nocturnal Hemoglobinuria	Drug: Cemdisiran;Drug: Eculizumab;Drug: Pozelimab;Drug: Ravulizumab	Regeneron Pharmaceuticals	NULL	Active, not recruiting	18 Years	N/A	All	2	Phase 3	United States
5	NCT05133531 (ClinicalTrials.gov)	August 1, 2022	12/11/2021	Ravulizumab-Controlled Non-Inferiority Study to Evaluate the Efficacy and Safety of Pozelimaband Cem ...	A Randomized, Open-Label, Ravulizumab-Controlled,Non-Inferiority Study to Evaluate the Efficacy and ...	Paroxysmal Nocturnal Hemoglobinuria	Drug: Ravulizumab;Drug: Pozelimab;Drug: Cemdisiran	Regeneron Pharmaceuticals	NULL	Recruiting	18 Years	N/A	All	148	Phase 3	United States;Canada;Greece;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Poland;Romania;Singapore; ...
6	EUCTR2020-002761-33-DE (EUCTR)	20/06/2022	03/03/2022	Efficacy and Safety of the Combination of Pozelimaband Cemdisiran versus continued Eculizumab or Rav ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
7	EUCTR2020-004486-40-GR (EUCTR)	17/06/2022	08/04/2022	Ravulizumab-Controlled Study to Evaluate the Efficacy and Safety of Pozelimaband Cemdisiran Combinat ...	A RANDOMIZED, OPEN-LABEL, RAVULIZUMAB-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF POZELI ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	124	Phase 3	Portugal;United States;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;Mexico;Canada ...
8	EUCTR2020-002761-33-GR (EUCTR)	17/06/2022	12/04/2022	Efficacy and Safety of the Combination of Pozelimaband Cemdisiran versus continued Eculizumab or Rav ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED, NON-INFERIORITY STUDY TO EVALUATE TH ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	134	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Thailand;Turkey;Colombia;United Kingdom;Italy ...
9	EUCTR2020-004486-40-ES (EUCTR)	09/05/2022	11/03/2022	Ravulizumab-Controlled Study to Evaluate the Efficacy and Safety of Pozelimaband Cemdisiran Combinat ...	A RANDOMIZED, OPEN-LABEL, RAVULIZUMAB-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF POZELI ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	124	Phase 3	Portugal;United States;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;Mexico;Canada ...
10	EUCTR2020-002761-33-ES (EUCTR)	09/05/2022	11/03/2022	Efficacy and Safety of the Combination of Pozelimaband Cemdisiran versus continued Eculizumab or Rav ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...

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