65. 原発性免疫不全症候群 Primary immunodeficiency Clinical trials / Disease details

臨床試験数 : 500 / 薬物数 : 614 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 217

11 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03597594 (ClinicalTrials.gov)	September 8, 2021	19/6/2018	Haplocompatible Transplant Using TCRa/ß Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infus ...	Haplocompatible Transplant Using TCRa/ß Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infus ...	Severe Combined Immunodeficiency	Drug: Anti-thymocyte globulin(rabbit);Drug: Busulfan;Drug: Fludarabine;Drug: Thiotepa;Device: CliniM ...	St. Jude Children's Research Hospital	NULL	Recruiting	2 Months	N/A	All	42	Phase 1/Phase 2	United States
2	JPRN-jRCTs031180398	30/05/2018	20/03/2019	A phase II study of RIC-SCT for CGD	Reduced intensity conditioning allogeneic stem cell transplantation with dose-adjusted busulfan and ...	Chronic granulomatous disease Primary immunodeficiency;D006105	Conditioning regimen with targeted-busulfanand fludarabin Total body irradiation (3Gy) at day -1 Ste ...	Sakaguchi Hirotoshi	NULL	Recruiting	Not applicable	< 25age old	Both	22	Phase 2	None (Japan only);Japan
3	JPRN-UMIN000030647	2017/12/30	31/12/2017	Reduced intensity conditioning allogeneic stem cell transplantation with dose-adjusted busulfan and ...	Reduced intensity conditioning allogeneic stem cell transplantation with dose-adjusted busulfan and ...	Chronic granulomatous disease	Conditioning regimen with targeted-busulfanand fludarabin Total body irradiation (3Gy) at day -1 Ste ...	National Center for Child Health and Development	NULL	Recruiting	Not applicable	25years-old	Male and Female	22	Phase 2	Japan
4	NCT02162420 (ClinicalTrials.gov)	January 10, 2015	10/6/2014	Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia	Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia	Dyskeratosis Congenita;Aplastic Anemia	Drug: Alemtuzumab;Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total Body Irradiation;Biologi ...	Masonic Cancer Center, University of Minnesota	NULL	Recruiting	0 Years	70 Years	All	50	N/A	United States
5	NCT01220531 (ClinicalTrials.gov)	November 8, 2010	22/9/2010	Thymus Transplantation Safety-Efficacy	Safety and Efficacy of Thymus Transplantation in Complete DiGeorge Anomaly, IND#9836	Complete DiGeorge Anomaly;DiGeorge Syndrome;DiGeorge Anomaly;Complete DiGeorge Syndrome	Biological: Cultured Thymus Tissue;Procedure: Blood Draw;Drug: Rabbit anti-thymocyte globulin;Drug: ...	M. Louise Markert	National Institutes of Health (NIH);National Institute of Allergy and Infectious Diseases (NIAID);En ...	Available	N/A	N/A	All			United States
6	NCT00579527 (ClinicalTrials.gov)	December 19, 2005	20/12/2007	Phase I/II Thymus Transplantation With Immunosuppression #950	Phase I/II Trial of Thymus Transplantation With Immunosuppression, #950	DiGeorge Anomaly;Complete DiGeorge Anomaly;Complete Atypical DiGeorge Anomaly;Complete DiGeorge Synd ...	Biological: Cultured Thymus Tissue for Implantation (CTTI);Other: Cultured Thymus Tissue Implantatio ...	Enzyvant Therapeutics GmBH	National Institutes of Health (NIH);National Institute of Allergy and Infectious Diseases (NIAID);Eu ...	Completed	N/A	N/A	All	14	Phase 1/Phase 2	United States
7	NCT00295971 (ClinicalTrials.gov)	April 2005	23/2/2006	Donor Stem Cell Transplant in Treating Young Patients With Myelodysplastic Syndrome, Leukemia, Bone ...	Stem Cell Enriched, T Cell Depleted Haplocompatible Peripheral Blood Transplantation for Children Wi ...	Congenital Amegakaryocytic Thrombocytopenia;Leukemia;Myelodysplastic Syndromes;Severe Congenital Neu ...	Biological: anti-thymocyte globulin;Biological: therapeutic allogeneic lymphocytes;Drug: fludarabine ...	University of California, San Francisco	National Cancer Institute (NCI)	Completed	1 Year	17 Years	Both	21	Phase 1	United States
8	NCT00305708 (ClinicalTrials.gov)	August 2000	21/3/2006	Busulfan, Antithymocyte Globulin, and Fludarabine Followed By a Donor Stem Cell Transplant in Treati ...	Bone Marrow Stem Cell Transplantation for Children With Stem Cell Defects, Marrow Failure Syndromes, ...	Congenital Amegakaryocytic Thrombocytopenia;Diamond-blackfan Anemia;Fanconi Anemia;Leukemia;Severe C ...	Biological: anti-thymocyte globulin;Drug: busulfan;Drug: fludarabine phosphate;Procedure: allogeneic ...	University of California, San Francisco	National Cancer Institute (NCI)	Completed	N/A	17 Years	Both	40	Phase 1/Phase 2	United States
9	NCT00176878 (ClinicalTrials.gov)	June 2000	12/9/2005	Stem Cell Transplant for Bone Marrow Failure Syndromes	Bone Marrow Transplantation for Non-Malignant Congenital Bone Marrow Failure Disorders	Diamond-Blackfan Anemia;Kostmann's Neutropenia;Shwachman-Diamond Syndrome	Procedure: Stem cell transplant;Drug: Fludarabine monophosphate;Procedure: Total lymphoid irradiation ...	Masonic Cancer Center, University of Minnesota	NULL	Completed	N/A	35 Years	All	10	Phase 2/Phase 3	United States
10	NCT00006054 (ClinicalTrials.gov)	March 2000	5/7/2000	Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies		Immunologic Deficiency Syndromes;Chediak-Higashi Syndrome;Common Variable Immunodeficiency;Graft Ver ...	Drug: anti-thymocyte globulin;Drug: busulfan;Drug: cyclophosphamide;Drug: cyclosporine;Drug: etoposi ...	Fairview University Medical Center	NULL	Terminated	N/A	35 Years	Both		N/A	United States

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