331. Idiopathic multicentric castleman disease Clinical trials / Disease details


Clinical trials : 33 Drugs : 41 - (DrugBank : 21) / Drug target genes : 22 - Drug target pathways : 123

  
6 trials found
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1ChiCTR2100048364
2021-09-012021-07-06A single-arm, prospective, and multicenter study of rituximab combined with lenalidomide in Castleman diseaseA single-arm, prospective, and multicenter study of rituximab combined with lenalidomide in Castleman disease Castleman diseaseTreatment group:Rituximab+lenalidomide;Department of Hematology, Jiangsu Provincial People's HospitalNULLPending1490BothTreatment group:20;Phase 4China
2NCT04585893
(ClinicalTrials.gov)
June 22, 202110/9/2020Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in MalawiLCCC 1950 - Rituximab for Multicentric Castleman Disease in Malawi, A Single-Arm Phase II Safety/Efficacy TrialMulticentric Castleman DiseaseDrug: Rituximab;Drug: EtoposideUNC Lineberger Comprehensive Cancer CenterFogarty International Center of the National Institute of HealthRecruiting18 YearsN/AAll27Phase 2Malawi
3NCT03864419
(ClinicalTrials.gov)
October 24, 20191/3/2019Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in UgandaA Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With Local Standard-of-Care Chemotherapy for the Treatment of Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma or as Monotherapy for Kaposi Sarcoma Herpesvirus Associated Multicentric Castleman Disease in Pediatrics and Adults in UgandaBurkitt Lymphoma;KSHV-associated Multicentric Castleman Disease;Diffuse Large B-Cell LymphomaBiological: Rituximab and Hyaluronidase Human;Drug: Cyclophosphamide;Drug: Vincristine;Drug: Methotrexate;Drug: Doxorubicin;Drug: Doxorubicin Hydrochloride;Drug: Prednisone;Drug: Etoposide;Biological: RituximabFred Hutchinson Cancer CenterNULLRecruiting2 YearsN/AAll40Phase 1Uganda;United States
4NCT02228512
(ClinicalTrials.gov)
August 15, 201427/8/2014Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated LymphomasPhase I/II Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas (Primary Effusion Lymphoma and Large Cell Lymphoma Arising in KSHV-Associated Multicentric Castleman Disease)Large Cell Lymphoma Arising in KSHV-associated Multicentric Castleman Disease;Primary Effusion LymphomaDrug: Pomalidomide;Drug: Rituximab;Drug: Prednisone;Drug: Etoposide;Drug: Doxorubicin;Drug: Vincristine;Drug: CyclophosphamideNational Cancer Institute (NCI)NULLWithdrawn18 Years99 YearsAll0Phase 1/Phase 2United States
5NCT00092222
(ClinicalTrials.gov)
October 28, 200421/9/2004Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease ActivityTargeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease With Laboratory and Clinical Correlates of Disease ActivityLymphoproliferative Disorder;HHV-8;Malignancy;HIVDrug: Etoposide;Drug: Interferon-alpha;Drug: Rituximab;Drug: Zidovudine;Drug: Liposomal Doxorubicin;Drug: Bortezomib;Drug: Valganciclovir;Drug: Doxorubicin;Drug: Vincristine;Drug: Cyclophosphamide;Drug: Filgrastim (G-CSF);Drug: Prednisone;Drug: Sirolimus;Other: Observation OnlyNational Cancer Institute (NCI)NULLActive, not recruiting18 YearsN/AAll75Phase 2United States
6NCT00127569
(ClinicalTrials.gov)
May 20034/8/2005Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on ChemotherapyMulticenter, Phase II Trial Assessing the Efficacy of Rituximab in HIV Infected Patients With Multicentric Castleman Disease Dependent on Chemotherapy (ANRS 117 Study, CastlemaB)HIV Infections;Giant Lymph Node HyperplasiaDrug: RituximabFrench National Agency for Research on AIDS and Viral HepatitisHoffmann-La RocheTerminated18 YearsN/ABoth25Phase 2NULL