66. IgA nephropathy Clinical trials / Disease details

Clinical trials : 275 / Drugs : 258 - (DrugBank : 82) / Drug target genes : 36 - Drug target pathways : 140

7 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2021-005609-28-ES (EUCTR)	18/03/2022	03/01/2022	Study to assess whether the drug Ravulizumab works in patients with kidney problems due to IgA immunoglobulin and who do not respond to corticosteroids	A PILOT PROOF-OF–CONCEPT STUDY TO ASSESS THE EFFICACY AND SAFETY OF A 6 MONTHS RAVULIZUMAB TREATMENT IN PATIENTS WITH FLARES OF CORTICOSTEROID-RESISTANT IDIOPATHIC IgA NEPHROPATHY	Treatment for IgA nephropathy flares;Therapeutic area: Body processes [G] - Immune system processes [G12]	Trade Name: Ultomiris 300 mg/30 ml INN or Proposed INN: Ravulizumab Other descriptive name: ALXN1210	Dr. Alfons Segarra Medrano	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1	Phase 4	Spain
2	NCT04020328 (ClinicalTrials.gov)	September 12, 2019	10/7/2019	Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency	A Randomized, Controlled Trial to Evaluate Leflunomide Plus Low Dose Corticosteroid Therapy in Progressive IgA Nephropathy With Renal Insufficiency	Glomerulonephritis, IGA;Renal Insufficiency, Chronic	Drug: Leflunomide 20 mg+prednisone 0.5mg/kg/d	Shenzhen Second People's Hospital	NULL	Recruiting	14 Years	65 Years	All	70	Phase 4	China
3	NCT02981212 (ClinicalTrials.gov)	June 2016	24/11/2016	Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy	Multi-center, Randomized, Open Label, Comparative, Phase IV Study to Evaluate the Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid for 48 Weeks in Advanced IgA Nephropathy	IgA Nephropathy	Drug: Mycophenolate Mofetil;Drug: ACE inhibitor;Drug: Corticosteroid;Drug: ARB	Yonsei University	Chong Kun Dang Pharmaceutical Corp.;Kyung Hee University Hospital at Gangdong;Kyungpook National University;Pusan National University Yangsan Hospital;Inje University;Seoul St. Mary's Hospital;Chonbuk National University Hospital	Recruiting	19 Years	65 Years	Both	100	Phase 4	Korea, Republic of
4	NCT03015974 (ClinicalTrials.gov)	January 2016	3/1/2017	Registry of IgA Nephropathy in Chinese Children	Registry of IgA Nephropathy in Chinese Children	IgA Nephropathy;Proteinuria in Nephrotic Range;Immunosuppressive Treatment	Drug: Corticosteroid;Drug: Cyclophosphamide;Drug: Mycophenolate mofetil;Drug: Dipyridamole;Drug: ACE Inhibitor or Angiotensin receptor antagonist	Peking University First Hospital	Nanjing PLA General Hospital;Beijing Children's Hospital;Central South University;The Children's Hospital of Zhejiang University School of Medicine;First Affiliated Hospital, Sun Yat-Sen University;Tongji Hospital;Hunan Children's Hospital;Shanghai Children's Hospital;Nanjing Children's Hospital;Children's Hospital of Chongqing Medical University;Shandong Provincial Hospital;Fuzhou General Hospital;Second Affiliated Hospital of Wenzhou Medical University;Children's Hospital of Hebei Province;Guangzhou Women and Children's Medical Center;Jiangxi Province Children's Hospital;Guangzhou First People's Hospital;Xian Children's Hospital;Capital Institute of Pediatrics, China;The First Hospital of Jilin University;Wuhan Women and Children's Medical Center;Tianjin Children's Hospital;Chengdu Women's and Children's Central Hospital;The First People's Hospital of Yunnan	Recruiting	1 Month	18 Years	All	1200		China
5	NCT02571842 (ClinicalTrials.gov)	January 2012	6/10/2015	Rituximab in Recurrent IgA Nephropathy	A Randomized, Prospective, Open-Label Study of Rituximab in the Treatment of Recurrent IgA Nephropathy With Active Endocapillary Proliferation Pathology	Recurrent IgA Nephropathy	Drug: Intravenous Rituximab;Drug: ACEI/ARB and corticosteroids	Chulalongkorn University	NULL	Recruiting	18 Years	70 Years	Both	30	Phase 4	Thailand
6	NCT00755859 (ClinicalTrials.gov)	May 1998	18/9/2008	Steroids and Azathioprine Versus Steroids Alone in IgAN	Corticosteroids and Azathioprine Versus Corticosteroids Alone in IgA Nephropathy: a Randomized Controlled Trial.	IGA Nephropathy	Drug: steroids plus azathioprine;Drug: steroids	A. Manzoni Hospital	NULL	Completed	16 Years	70 Years	Both	206	Phase 4	Italy;Switzerland
7	NCT00367562 (ClinicalTrials.gov)	January 1996	22/8/2006	Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy	Phase IV Open Label Uncontrolled Trial of the Dual Blockade of the Renin Angiotensin System With Enalapril Plus Valsartan Combined With Oral Methylprednisolone for the Treatment of Proteinuria in IGA Nephropathy	IGA Nephropathy	Drug: ENALAPRIL VALSARTAN METHYLPREDNISONE	Hospital Britanico	NULL	Completed	21 Years	70 Years	Both	20	Phase 4	Argentina