Gold ( DrugBank: Gold )

43 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	3
5	進行性核上性麻痺	2
6	パーキンソン病	17
13	多発性硬化症／視神経脊髄炎	7
17	多系統萎縮症	2
34	神経線維腫症	2
35	天疱瘡	2
46	悪性関節リウマチ	6
49	全身性エリテマトーデス	2
50	皮膚筋炎／多発性筋炎	2
53	シェーグレン症候群	2
58	肥大型心筋症	1
63	特発性血小板減少性紫斑病	1
65	原発性免疫不全症候群	2
68	黄色靱帯骨化症	1
76	下垂体性ゴナドトロピン分泌亢進症	4
84	サルコイドーシス	2
86	肺動脈性肺高血圧症	5
91	バッド・キアリ症候群	1
93	原発性胆汁性胆管炎	3
95	自己免疫性肝炎	1
96	クローン病	4
97	潰瘍性大腸炎	2
98	好酸球性消化管疾患	1
113	筋ジストロフィー	1
137	限局性皮質異形成	1
158	結節性硬化症	1
162	類天疱瘡（後天性表皮水疱症を含む。）	1
167	マルファン症候群	1
171	ウィルソン病	2
193	プラダー・ウィリ症候群	1
218	アルポート症候群	1
222	一次性ネフローゼ症候群	5
224	紫斑病性腎炎	1
226	間質性膀胱炎（ハンナ型）	1
227	オスラー病	1
230	肺胞低換気症候群	1
271	強直性脊椎炎	1
291	ヒルシュスプルング病（全結腸型又は小腸型）	1
296	胆道閉鎖症	9
298	遺伝性膵炎	1
310	先天異常症候群	1
318	シトリン欠損症	1

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03843710 (ClinicalTrials.gov)	April 30, 2021	14/2/2019	31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)	A Phase 2, Pilot Open Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	Drug: Gold Nanocrystals	Clene Nanomedicine	University of Texas Southwestern Medical Center	Not yet recruiting	35 Years	75 Years	All	24	Phase 2	United States
2	ChiCTR1900024520	2019-07-22	2019-07-13	Split-hand index calculated by F-wave test apply to the diagnosis of amyotrophic lateral sclerosis	Split-hand index calculated by F-wave test apply to the diagnosis of amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	Gold Standard:Clinical outcome meet the Awaji-Shima Criteria 2008;Index test:Split-hand index calculated by F-wave test;	Peking Union Medical College Hospita	NULL	Recruiting	18	80	Both	Target condition:300;Difficult condition:50	N/A	China
3	NCT03690791 (ClinicalTrials.gov)	January 9, 2019	13/9/2018	Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease	A Randomised, Double-blind, Single-centre Study on the Safety, Tolerability and Efficacy of Cannabis Based Medicine Extract (MediCabilis CBD Oil) in Slowing the Disease Progression in Amyotrophic Lateral Sclerosis or Motor Neurone Disease Patients	Amyotrophic Lateral Sclerosis;Motor Neuron Disease	Drug: MediCabilis CBD Oil;Drug: Placebo Oil	Gold Coast Hospital and Health Service	BOD Australia	Recruiting	25 Years	80 Years	All	30	Phase 3	Australia

5. 進行性核上性麻痺

臨床試験数 : 89 / 薬物数 : 107 - (DrugBank : 40) / 標的遺伝子数 : 65 - 標的パスウェイ数 : 108

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000041207	2021-01-01	2020-12-22	A registered cohort study on progressive supranuclear palsy (PSP)	A registered cohort study on progressive supranuclear palsy (PSP)	progressive supranuclear palsy	Gold Standard:Diagnostic criteria of MDS for progressive supra-nuclear palsy (2017) and the Chinese clinical diagnostic criteria for progressive supra-nuclear palsy (2016).;Index test:The progression of PSP rating scales. Tau protein-related pathological examination (for example, Tau protein content in blood, Tau protein-related detection in cerebrospinal fluid in patients with cognitive impairment, etc.), and brain Tau PET imaging.;	Huashan Hospital, Fudan University	NULL	Recruiting	40	85	Both	Target condition:100;Difficult condition:0		China
2	ChiCTR2000030512	2019-05-13	2020-03-05	Clinical study of [18F]-APN-1607([18F]-PM-PBB3) PET on tau tangles in the brain of progressive supranuclear palsy	Clinical study of [18F]-APN-1607([18F]-PM-PBB3) PET on tau tangles in the brain of progressive supranuclear palsy	progressive supranuclear palsy	Gold Standard:clinical diagnosis of progressive supranuclear palsy the movement disorder society criteria in 2017.(Mov Disord. 2017 Jun;32(6):853-864. doi: 10.1002/mds.26987. Epub 2017 May 3.).;Index test:Standard uptake value ratio of [18F]-APN-1607([18F]-PM-PBB3);	Huashan Hospital, Fudan University	NULL	Recruiting	45	80	Both	Target condition:26;Difficult condition:0		China

6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200059588	2022-06-01	2022-05-04	Analysis of speech disorders in patients with Parkinson's disease based on speech signals and machine learning	Analysis of speech disorders in patients with Parkinson's disease based on speech signals and machine learning	Parkinson's Disease	Gold Standard:Parkinson's speech features that can be used for recognition ;Index test:Extract the multi-modal speech features of Parkinson's patients using the developed speech signal processing algorithm ;	Provincial Government Hospital in Jiangsu Province	NULL	Pending	18	75	Both	Target condition:200;Difficult condition:0	N/A	China
2	ChiCTR2200059544	2021-09-01	2022-05-04	Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease under General Anesthesia	Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease under General Anesthesia	Parkinson's disease	Gold Standard:Clinical outcome;Index test:The clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson's disease under general anesthesia.;	First Affiliated Hospital of Sun Yat-sen University	NULL	Completed	18	80	Both	Target condition:240;Difficult condition:0		China
3	ChiCTR2100044662	2021-04-01	2021-03-25	Study on exosome biomarkers in Parkinson's disease	Study on exosome biomarkers in Parkinson's disease	Parkinson’s disease	Gold Standard:Clinically established Parkinson's disease conforming to China Diagnostic Criteria for Parkinson's Disease (2016);Index test:Exosome biomarkers (miRNA and a-synuclein);	The First Affiliated Hospital, Sun Yat-sen University	NULL	Recruiting	21	100	Both	Target condition:1200;Difficult condition:0		China
4	ChiCTR2000038937	2020-11-01	2020-10-10	Clinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imaging	Clinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imaging	Parkinson's disease	Gold Standard:Clinical diagnosis by experienced movement disorder specialists after 2 years of follow-up.;Index test:Including traditional imaging feature algorithms (SUVR value, total cortical volume, bilateral cortical surface area, cortical thickness, etc.), high-dimensional imaging omics feature algorithms (energy entropy, gray-level co-occurrence matrix, and mutual information, etc.), and brain connection group Learning feature algorithm.;	Huashan Hospital, Fudan University	NULL	Recruiting	45	80	Both	Target condition:105;Difficult condition:0		China
5	ChiCTR2000036137	2020-10-01	2020-08-21	Clinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's disease	Clinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's disease	Parkinson’s disease	Gold Standard:UK Parkinson's disease Society Brain Bank Clinical Diagnosis Criteria;Index test:18F-FDG combined with 18F-AV-133 PET/CT imaging;	Renji Hospital (South Court), School of Medicine, Shanghai Jiao Tong University	NULL	Pending			Both	Target condition:50;Difficult condition:0		China
6	ChiCTR2000036006	2020-10-01	2020-08-21	The applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learning	The applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learning	Parkinson's disease	Gold Standard:MDS clinical diagnostic criteria for Parkinson’s disease;Index test:multimodal MRI features in locus coeruleus and substantia nigra;	Zhongshan Hospital, Fudan University	NULL	Pending	18	85	Both	Target condition:400;Difficult condition:0		China
7	ChiCTR2000037239	2020-10-01	2020-08-27	Construction and application of a diagnostic marker for Parkinson's disease based on gut microbiomics	Construction and application of a diagnostic marker for Parkinson's disease based on gut microbiomics	Parkinson's disease	Gold Standard:All patients satisfied the United Kingdom Parkinson's Disease Society Brain Bank criteria;Index test:Microbial gene detection chip;	Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine	NULL	Recruiting	55	80	Both	Target condition:500;Difficult condition:600		China
8	ChiCTR2000037856	2020-10-01	2020-09-02	Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)	Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)	Parkinson's Disease	Gold Standard:DAT-PET and 18F-FDG PET ;Index test:a-synuclein protein misfolding cyclic amplification;	Huashan Hospital Affiliated to Fudan University	NULL	Recruiting	50	75	Both	Target condition:150;Difficult condition:76		China
9	ChiCTR2000032616	2020-05-30	2020-05-04	Assistant diagnosis machinery system development based on speech and movement sensitive device for Parkinson's disease	Parkinson's disease, Assistant diagnosis machinery system, speech, movement sensitive device	Parkinson's disease	Gold Standard:clinical outcome meet 2015 MDS-probable PD criteria;Index test:Acoustic receptive and analysis device,Wearable movement sensor;	Shanghai Jiao Tong University School of Medicine affiliated Shanghai General Hospital	NULL	Pending			Both	Target condition:20;Difficult condition:80		China
10	NCT03815916 (ClinicalTrials.gov)	December 19, 2019	18/1/2019	31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Parkinson's Disease	A Phase 2, Pilot Open Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Parkinson's Disease	Parkinson's Disease	Drug: Gold Nanocrystals	Clene Nanomedicine	University of Texas Southwestern Medical Center	Completed	30 Years	80 Years	All	13	Phase 2	United States
11	ChiCTR1900027306	2019-11-15	2019-11-08	Application of optical coherence tomography and detection of a-synuclein in tears in the diagnosis of Parkinson's disease	Morphological changes of retina in patients with Parkinson's disease and the role of a-synuclein in retinal damage	Parkinson's disease	Gold Standard:British brain bank Parkinson's disease diagnostic criteria;Index test:Application of optical coherence tomography to observe the retinal structure of the macular area, optic disc area and the expression level of a-synuclein in tears in the diagnosis of Parkinson's disease.;	The First Affiliated Hospital of Chengdu Medical College	NULL	Recruiting			Both	Target condition:85;Difficult condition:85		China
12	ChiCTR1800015757	2019-04-01	2018-04-18	Value of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's disease	Value of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's disease	Parkinson's Disease	Gold Standard:PD diagnostic criteria made by MDS in 2016;Index test:reduced uptake in salivery gland and myocardium in I-131-MIBG scintigraphic imaging;	Tongji hospital, Tongji University	NULL	Pending			Both	Target condition:30;Difficult condition:30		China
13	ChiCTR-DDD-16009569	2017-01-01	2016-10-24	Differential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imaging	Differential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imaging	Parkinson's Disease	Gold Standard:;Index test:;	Renji hospital, School of Medicine, Shanghai Jiao Tong University	NULL	Pending	20	80	Both	Target condition:0;Difficult condition:0		China
14	ChiCTR-DOC-16008645	2016-07-01	2016-06-15	The study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's disease	The study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's disease	Parkinson Disease	Gold Standard:;Index test:;	101th Hospital of PLA	NULL	Pending	18	80	Both	Target condition:0;Difficult condition:0		NULL
15	ChiCTR-DRD-16008778	2016-07-01	2016-07-04	The study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi mode	The study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi mode	Parkinson`s Disease	Gold Standard:;Index test:;	Xiangyang Hospital, Hubei University of Medicine	NULL	Recruiting			Both	Target condition:0;Difficult condition:0		China
16	ChiCTR-DOD-15006097	2015-03-18	2015-03-16	The diagnostic value of olfactory-evoked potentials in Parkinson'sdisease	The diagnostic value of olfactory-evoked potentials in Parkinson'sdisease	Parkinson's disease	Gold Standard:;Index test:;	Guangdong General Hospital, Guangdong Academy of Medical Sciences	NULL	Recruiting	50	80	Both	Target condition:0;Difficult condition:0		China
17	ChiCTR-DDD-17010794	2014-11-08	2017-03-05	The study on early diagnosis of Parkinson 's disease by transcranial ultrasonography	the study on early diagnosis of Parkinson 's disease by transcranial ultrasonography	Parkinson's Disease	Gold Standard:Diagnosis of Parkinson disease needs to meet 3 or more: unilateral onset;resting tremor;progressive course; long term asymmetry, the most obvious symptoms is the onset side; a good response to levodopa (70% ~ 100%); levodopa induced chorea; a reaction of levodopa lasts 5 years or more; clinical course last;Index test:Laboratory apparatus As shown in Figure 1, The ultrasound equipment, Philips IE33-BOMJH1 color Doppler ultrasonography, Model IE-ELite, with 2-4MHz phased array probe (S5-1 probe) was used for TCS to examine SN in our study. Transcranial ultrasound study Ultrasonography through temporal window, alon;	Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital	NULL	Completed	36	84	Both	Target condition:135;Difficult condition:0		China

先頭へ

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100052936	2021-11-10	2021-11-06	The establishment of metabolic fingerprints-aided diagnostic model of neuromyelitis optica spectrum disorder	High-throughput metabolic fingerprints characterize neuromyelitis optica spectrum disorder	Neuromyelitis Optica Spectrum Disorders	Gold Standard:Cell-based assay (CBA) for antibody testing as recommended.;Index test:Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is responsible for the obtainment of biofluid metabolic fingerprints, which is further processed by machine learning algorithm, yielding Receiver Operating Characteristic (ROC) curve and area under curve (AUC) calculated to provide comparison.;	Renji Hospital, School of Medicine, Shanghai Jiao Tong University	NULL	Pending	18	85	Both	Target condition:76;Difficult condition:13	N/A	China
2	ChiCTR2000040363	2020-11-23	2020-11-28	Clinical study of cerebrospinal fluid immunoglobulin G oligoclonal band detection in Chinese patients with multiple sclerosis	Clinical study of cerebrospinal fluid immunoglobulin G oligoclonal band detection in Chinese patients with multiple sclerosis	Multiple Sclerosis	Gold Standard:Isoelectric focusing electrophoresis;Index test:(1) CSF IgG index (2) CSF 24-hour intrathecal synthesis rate (3) CSF-OCB testing type (4) CSF-OCB positive rate;	Huashan Hospital, Fudan University	NULL	Recruiting	14	65	Both	Target condition:180;Difficult condition:90	N/A	China
3	ChiCTR2000034098	2020-07-01	2020-06-23	A New Quantitative Method Used to Evaluate Cervical Spinal Cord Damage in Multiple Sclerosis: Diffusional Kurtosis Imaging Research	A New Quantitative Method Used to Evaluate Cervical Spinal Cord Damage in Multiple Sclerosis: Diffusional Kurtosis Imaging Research	Multiple Sclerosis	Gold Standard:Conventional cervical MRI;Index test:Diffusional Kurtosis Imaging;	The First Hospital of Jilin University	NULL	Pending			Both	Target condition:48;Difficult condition:0		China
4	NCT03993171 (ClinicalTrials.gov)	December 19, 2019	31/5/2019	31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.	A Phase 2, Open-Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Multiple Sclerosis.	Relapsing Remitting Multiple Sclerosis	Drug: gold nanocrystals	Clene Nanomedicine	University of Texas Southwestern Medical Center	Recruiting	18 Years	55 Years	All	30	Phase 2	United States
5	NCT04120675 (ClinicalTrials.gov)	November 9, 2018	24/9/2019	Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis	The Effects of Early Harvest Extra Virgin Olive Oil on Cognition and Mental Health of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis Patients	Progressive Multiple Sclerosis	Dietary Supplement: Early Harvest Extra Virgin Olive Oil	Aristotle University Of Thessaloniki	Greek Alzheimer's Association and Related Disorders;Ellis-Farm, Eliama Daily Value Gold (ellis-farm.com)	Completed	18 Years	65 Years	All	30	N/A	Greece
6	ChiCTR-DND-17013749	2017-12-01	2017-12-07	Application of 3.0 T MRI 3D sequences of CUBE-T2 FLAIR?DIR for brain lesions of childhood-onset multiple sclerosis	Application of 3.0 T MRI 3D sequences of CUBE-T2 FLAIR?DIR for brain lesions of childhood-onset multiple sclerosis	childhood-onset multiple sclerosis	Gold Standard:CUBE-T2 FLAIR scanning;Index test:DIR scanning;	Children's Hospital of Chongqing Medical University	NULL	Recruiting			Both	Target condition:80;Difficult condition:0		China
7	EUCTR2010-024017-31-IT (EUCTR)	15/03/2011	08/02/2011	A 6-month, Randomized, Active Comparator, Open-label, Multi-Center Study to Evaluate Patient OutComes, Safety and Tolerability of Fingolimod (FTY720) 0.5 mg/day in Patients with Relapsing Remitting Multiple Sclerosis who are candidates for MS therapy change from Previous Disease Modifying Therapy - GOLDEN	A 6-month, Randomized, Active Comparator, Open-label, Multi-Center Study to Evaluate Patient OutComes, Safety and Tolerability of Fingolimod (FTY720) 0.5 mg/day in Patients with Relapsing Remitting Multiple Sclerosis who are candidates for MS therapy change from Previous Disease Modifying Therapy - GOLDEN	Relapsing Remitting Multiple Sclerosis MedDRA version: 9.1;Level: LLT;Classification code 10063399	Product Name: FINGOLIMOD Product Code: FTY720D Trade Name: EXTAVIA INN or Proposed INN: Interferon beta-1b Trade Name: AVONEX INN or Proposed INN: Interferon beta-1a Trade Name: COPAXONE INN or Proposed INN: Glatiramer acetate	NOVARTIS FARMA	NULL	Not Recruiting			Female: yes Male: yes			Italy

先頭へ

17. 多系統萎縮症

臨床試験数 : 119 / 薬物数 : 138 - (DrugBank : 44) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 111

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000033282	2020-06-01	2020-05-26	Construction of cohort and prognosis prediction model of multiple system atrophy	Construction of cohort and prognosis prediction model of multiple system atrophy	Multiple system atrophy	Gold Standard:Clinical outcomes.;Index test:Prognosis prediction model of multiple system atrophy;	West China Hospital of Sichuan University	NULL	Recruiting	30	75	Both	Target condition:600;Difficult condition:0		China
2	ChiCTR-DPC-15005941	2015-03-01	2015-01-25	Study for the diagnosis and differential diagnosis of multiple system atrophy	Study for the diagnosis and differential diagnosis of multiple system atrophy	Multiple system atrophy	Gold Standard:electrophysiological techniques;Index test:brain MRI;	Navy general hospital	NULL	Completed	30	80	Both	Target condition:260;Difficult condition:0		China

34. 神経線維腫症

臨床試験数 : 133 / 薬物数 : 186 - (DrugBank : 67) / 標的遺伝子数 : 79 - 標的パスウェイ数 : 190

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000036770	2020-10-01	2020-08-25	Establishment of prediction model of selumetinib therapy in the treatment of plexiform neurofibroma based on exosomes test from liquid biopsy	Establishment of prediction model of selumetinib therapy in the treatment of plexiform neurofibroma based on exosomes test from liquid biopsy	Plexiform Neurofibromatosis type 1	Gold Standard:Clinical outcomes;Index test:Prediction model of selumetinib therapy in the treatment of plexiform neurofibroma based on exosomes test from liquid biopsy;	Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine	NULL	Pending	2	65	Both	Target condition:32;Difficult condition:0		China
2	ChiCTR-DDD-16009551	2016-10-28	2016-10-23	Comparative study of Sanger sequencing and specific panel high-throughput sequencing for detection of NF1 pathogenic mutations in Han Chinese	Comparative study of Sanger sequencing and specific panel high-throughput sequencing for detection of NF1 pathogenic mutations in Han Chinese	neurofibromatosis;M95400/1	Gold Standard:;Index test:;	Shanghai 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine	NULL	Recruiting	10	45	Both	Target condition:0;Difficult condition:0		China

35. 天疱瘡

臨床試験数 : 99 / 薬物数 : 124 - (DrugBank : 36) / 標的遺伝子数 : 23 - 標的パスウェイ数 : 169

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100042023	2018-06-01	2021-01-12	Evaluation of salivary anti Dsg1 and Dsg3 antibodies in diagnosis and monitoring of pemphigus vulgaris	Evaluation of salivary anti Dsg1 and Dsg3 antibodies in diagnosis and monitoring of pemphigus vulgaris	Pemphigus vulgaris	Gold Standard:Gold standard: At the same time, it met the diagnostic criteria of pemphigus vulgaris of Japan Dermatology Association in 2014 and was confirmed by two experts. Diagnostic criteria: including clinical manifestations, histopathological examination and immunodiagnostic indicators.;Index test:Salivary Dsg1 and Dsg3 titer;	Peking University School and Hospital of Stomatology	NULL	Recruiting			Both	Target condition:38;Difficult condition:38		China
2	ChiCTR2100042024	2018-06-01	2021-01-12	Direct immunofluorescence of Tzanck smears for the diagnosis of pemphigus vulgaris: a diagnostic test	Direct immunofluorescence of Tzanck smears for the diagnosis of pemphigus vulgaris: a diagnostic test	Pemphigus vulgaris	Gold Standard:Gold standard: meet the diagnostic criteria of pemphigus vulgaris of Japan Dermatology Association in 2014 and the diagnosis made by two experts. Diagnostic criteria: including clinical manifestations, histopathological examination and immunodiagnostic indicators.;Index test:Direct immunofluorescence of Tzanck smears;	Peking University stomatological hospital	NULL	Recruiting			Both	Target condition:38;Difficult condition:38		China

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200057350	2022-02-25	2022-03-09	Predictive value of TyG index and rheumatoid factor levels for cardiovascular disease risk in a population with rheumatoid arthritis	Predictive value of TyG index and rheumatoid factor levels for cardiovascular disease risk in a population with rheumatoid arthritis	rheumatoid arthritis	Gold Standard:Rheumatoid arthritis disease diagnosis is based on the ACR/EULAR criteria published in 2010 ;Index test:TyG index,rheumatoid factor;	China-Japan Friendship Hospital	NULL	Pending	18	75	Both	Target condition:150;Difficult condition:150		China
2	ChiCTR1800018637	2018-09-26	2018-09-30	Correlation between Human epididymis protein 4 and interstitial lung disease in patients with rheumatoid arthritis	Correlation between Human epididymis protein 4 and interstitial lung disease in patients with rheumatoid arthritis	rheumatoid arthritis	Gold Standard:Clinical outcome, meet the 2010 ACR/EULAR rheumatoid arthritis classification criteria.;Index test:Human epididymis protein 4,anti-cyclic citrullinated peptide, creatinine, rheumatoid factor;	Affiliated Hospital of North Sichuan Medical College	NULL	Recruiting			Both	Target condition:150;Difficult condition:100		China
3	ChiCTR-DDT-12002658	2012-12-01	2012-11-04	Validation of early rheumatoid arthritis classification criteria	Validation of early rheumatoid arthritis classification criteria	rheumatoid arthritis	Gold Standard:;Index test:;	Peking University People's Hospital	NULL	Completed	16	100	Both	Target condition:0;Difficult condition:0		China
4	ChiCTR-DDT-12002268	2011-06-11	2012-06-11	Early diagnosis of rheumatoid arthritis	Study on the clinical application of imaging in early rheumatoid	rheumatoid arthritis	Gold Standard:;Index test:;	Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University	NULL	Completed	18	65	Both	Target condition:0;Difficult condition:0		China
5	EUCTR2010-019514-24-CZ (EUCTR)	21/04/2011	06/12/2010	Study to determine the effects of different doses of Methotrexate (MTX) when taken with adalimumab in subjects with Early Rheumatoid Arthritis (RA)	A Double-Blind, Randomized, Parallel-Arm, Multi-Center Study to Determine the Dose Response of Methotrexate (MTX) in Combination Therapy with Adalimumab in Subjects with Early Rheumatoid Arthritis. - CONCERTO	Rheumatoid Arthritis. MedDRA version: 14.1;Level: PT;Classification code 10039073;Term: Rheumatoid arthritis;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders;Therapeutic area: Diseases [C] - Immune System Diseases [C20]	Trade Name: Humira INN or Proposed INN: ADALIMUMAB Trade Name: MTX HEXAL Tablets INN or Proposed INN: METHOTREXATE Trade Name: MTX Goldshield Tablets INN or Proposed INN: METHOTREXATE	AbbVie Deutschland GmbH & Co. KG	NULL	Not Recruiting			Female: yes Male: yes	380		United States;Czech Republic;Canada;Puerto Rico;Argentina;Spain;Belgium;Austria;Germany
6	EUCTR2007-001190-28-GB (EUCTR)	09/05/2007	17/04/2007	Randomised controlled trial of tumour-necrosis-factor inhibitors against combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis - TACIT	Randomised controlled trial of tumour-necrosis-factor inhibitors against combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis - TACIT	Rheumatoid Arthritis MedDRA version: 9.1;Level: LLT;Classification code 10039073;Term: Rheumatoid arthritis	Product Name: Methotrexate Product Code: Methotrexate INN or Proposed INN: METHOTREXATE Product Name: Sulfasalazine Product Code: Sulfasalazine INN or Proposed INN: SULFASALAZINE Product Name: Hydroxychloroquine Product Code: Hydroxychloroquine INN or Proposed INN: Hydroxychloroquine Product Name: Ciclosporin Product Code: Ciclosporin INN or Proposed INN: Ciclosporin Product Name: Leflunomide Product Code: Leflunomide INN or Proposed INN: Leflunomide Product Name: Sodium aurothiomalate (intramuscular gold) Product Code: Sodium aurothiomalate (intramuscular gold) INN or Proposed INN: Sodium aurothiomalate Product Name: methylprednisolone Product Code: methylprednisolone INN or Proposed INN: Methylprednisolone Product Name: Prednisolone Product Code: Predniso	King's College London	NULL	Not Recruiting			Female: yes Male: yes	190	Phase 4	United Kingdom

先頭へ

49. 全身性エリテマトーデス

臨床試験数 : 993 / 薬物数 : 702 - (DrugBank : 184) / 標的遺伝子数 : 116 - 標的パスウェイ数 : 200

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100048082	2021-07-01	2021-06-30	Identification of Serum and Exosome Markers in Lupus Nephritis	Development and Application of an Early Diagnosis Scheme for Lupus Nephritis Based on Serum Noncoding Small RNA	Systemic Lupus Erythematosus	Gold Standard:The SLE classification standard revised by the American Academy of Rheumatology in 1997 and the SLE classification standard revised by the American Academy of Rheumatology in 2009;Index test:serum and exosome markers;	The Affiliated Drum Tower Hospital of Nanjing University Medical School	NULL	Recruiting			Both	Target condition:100;Difficult condition:100		China
2	ChiCTR2000038519	2020-10-01	2020-09-23	A study of T lymphocyte subsets in children with systemic lupus erythematosus	A study of T lymphocyte subsets in children with systemic lupus erythematosus	systemic lupus erythematosus in children	Gold Standard:anti-nuclear antibodies;Index test:WBC, CD4+T cells, CD4+CCR7+CD95+T cells, CD4+CD45RA-CCR7+T cells, CD4+CD45RA-CCR7-Tcells;	Tianjin Children's Hospital	NULL	Pending	8	17	Both	Target condition:100;Difficult condition:50	N/A	China

50. 皮膚筋炎／多発性筋炎

臨床試験数 : 194 / 薬物数 : 244 - (DrugBank : 89) / 標的遺伝子数 : 50 - 標的パスウェイ数 : 151

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000031286	2020-03-27	2020-03-26	Establishment and validation of the risk prediction model of dermatomyositis combined with malignant tumor nomogram	Establishment and validation of the risk prediction model of dermatomyositis combined with malignant tumor nomogram	Dermatomyositic	Gold Standard:Clinical outcomes (whether combined with malignant tumor);Index test:The risk prediction model of dermatomyositis combined with malignant tumor nomogram;	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	NULL	Recruiting	85	1	Both	Target condition:240;Difficult condition:0		China
2	ChiCTR-DDD-16009687	2016-10-28	2016-10-28	The precision diagnosis of dermatomyositis with malignant tumor or fatal interstitial lung disease	The precision diagnosis of dermatomyositis with malignant tumor or fatal interstitial lung disease	Dermatomyositis	Gold Standard:;Index test:;	Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University	NULL	Recruiting	18		Both	Target condition:0;Difficult condition:0		China

53. シェーグレン症候群

臨床試験数 : 305 / 薬物数 : 325 - (DrugBank : 104) / 標的遺伝子数 : 58 - 標的パスウェイ数 : 188

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100042744	2021-02-01	2021-01-27	To explore the value of serological, salivary and histological examinations in the diagnosis of Sjogren's syndrome	To explore the value of serological, salivary and histological examinations in the diagnosis of Sjogren's syndrome	Sjogren syndrome	Gold Standard:AECC standards proposed by the United States and European Union in 2020, including primary and secondary.;Index test:1. Serum ANA, anti-SSA /SSB antibody; 2. ultrasonography of salivary glands; 3. nuclide imaging of salivary glands; 4. Labial gland biopsy.;	Longyan First Affiliated Hospital of Fujian Medical University	NULL	Recruiting			Both	Target condition:60;Difficult condition:20		China
2	ChiCTR2000035194	2020-10-01	2020-08-02	The value of exosome miR29 for biomarker of primary Sjogren's syndrome with interstitial lung disease	The value of exosome miR29 for biomarker of primary Sjogren's syndrome with interstitial lung disease	Sjogren's syndrome; Interstitial lung disease	Gold Standard:According to the clinical manifestations, chest imaging (cell-like change, ground glass change, solid shadow, mesh shadow), lung ventilation and diffusion function (FVC, DLCO), pathological biopsy and the elimination of ILD caused by other known reasons. If necessary, a surgical lung biopsy is feasible.;Index test:miRNA-29;	Tongji Hosipital, Tongji University School of Medicine	NULL	Recruiting	18		Both	Target condition:60;Difficult condition:60		China

58. 肥大型心筋症

臨床試験数 : 126 / 薬物数 : 135 - (DrugBank : 42) / 標的遺伝子数 : 46 - 標的パスウェイ数 : 162

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100048388	2021-07-01	2021-07-06	The prognostic value of myocardial fibrosis in patients with hypertrophic cardiomyopathy	The prognostic value of myocardial fibrosis in patients with hypertrophic cardiomyopathy: a prospective study based on 18FAl-NOTA-FAPI-04 imaging	hypertrophic cardiomyopathy	Gold Standard:Clinical outcome;Index test:18FAl-NOTA-FAPI imaging quantitatively detect myocardial fibrosis;	Beijing Chaoyang Hospital, Capital Medical University	NULL	Pending	14		Both	Target condition:100;Difficult condition:0		China

63. 特発性血小板減少性紫斑病

臨床試験数 : 391 / 薬物数 : 235 - (DrugBank : 50) / 標的遺伝子数 : 49 - 標的パスウェイ数 : 139

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200060164	2022-06-01	2022-05-21	Application of immune cell detection in disease prediction and therapeutic drug selection in patients with primary immune thrombocytopenia	Application of immune cell detection in disease prediction and therapeutic drug selection in patients with primary immune thrombocytopenia	primary immune thrombocytopenia (ITP)	Gold Standard:Clinical outcome;Index test:Immunocell detection;	Anhui Provincial Hospital	NULL	Pending			Both	Target condition:20;Difficult condition:0	N/A	China

65. 原発性免疫不全症候群

臨床試験数 : 500 / 薬物数 : 614 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 217

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100043049	2021-02-04	2021-02-04	The application of T/B cell antigen-treated shear ring (Trecs/Krecs) quantitative PCR detection in neonatal screening for primary immunodeficiency disease	The application of T/B cell antigen-treated shear ring (Trecs/Krecs) quantitative PCR detection in neonatal screening for primary immunodeficiency disease	Severe combined immunodeficiency	Gold Standard:TRECs: 40 copies / µ l whole blood Krecs: 40 copies / µ l whole blood RNase P: 2000 copies / µ l whole blood;Index test:Quantitative detection of TRECs / krecs and housekeeping gene plasmid by PCR;	Chengdu Women's and Children's Center Hospital	NULL	Recruiting			Both	Target condition:20000;Difficult condition:0		China
2	ChiCTR2000032139	2020-09-01	2020-04-20	Newborn screening and precision medical system construction for primary immunodeficiency disease	Newborn screening and precision medical system construction for primary immunodeficiency disease	primary immunodeficiency	Gold Standard:1. Whether there is immune deficiency; 2. Primary or secondary, persistent or temporary; 3. The part and degree of the defect of immune system; 4. Molecular diagnosis: sequence the first / second generation genes to detect whether there is pathogenic gene mutation; detection of relative protein molecular.;Index test:PID newborn screening technology system based on TRECs/KRECs combined with quantitative PCR detection;	Children's Hospital of Chongqing Medical University	NULL	Recruiting	0	1	Both	Target condition:50000;Difficult condition:0		China

68. 黄色靱帯骨化症

臨床試験数 : 2 / 薬物数 : 4 - (DrugBank : 4) / 標的遺伝子数 : 1 - 標的パスウェイ数 : 3

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000030380	2020-02-15	2020-02-29	The diagnostic accuracy of CT-based ''Banner cloud sign'' for dural ossification in patients with thoracic ossification of the ligamentum flavum: a prospective, blinded, diagnostic accuracy study protocol	The diagnostic accuracy of CT-based ''Banner cloud sign'' for dural ossification in patients with thoracic ossification of the ligamentum flavum: a prospective, blinded, diagnostic accuracy study protocol	ossification of ligamentum flavum combined with dural ossification	Gold Standard:Operation notes.;Index test:CT images of thoracic spine: Banner clouds sign, Tram track sign and Comma sign.;	Peking University Third Hospital	NULL	Recruiting	0	99	Both	Target condition:132;Difficult condition:0		China

76. 下垂体性ゴナドトロピン分泌亢進症

臨床試験数 : 29 / 薬物数 : 44 - (DrugBank : 14) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 15

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100054310	2021-12-13	2021-12-13	Diagnostic significance of random urinary gonadotropin levels in girls with central precocious puberty	Diagnostic significance of random urinary gonadotropin levels in girls with central precocious puberty	precocious puberty	Gold Standard:Randomized urinary gonadotropin levels;Index test:Gonadotropin-releasing hormone challenge test;	Children's Hospital Affiliated to Zhejiang University School of Medicine	NULL	Pending	4	10	Both	Target condition:60;Difficult condition:40	N/A	China
2	ChiCTR2100047299	2020-12-01	2021-06-12	The use of morning urinary gonadotropins and sexual hormones in the diagnosis and monitoring treatment of central precocious puberty	The use of morning urinary gonadotropins and sexual hormones in the diagnosis and monitoring treatment of central precocious puberty	precocious puberty	Gold Standard:gonadotropin releasing hormone stimulation test ;Index test:luteinizing hormone, follicle stimulating hormone, estradiol, prolactin, progesterone, testosterone, and human chorionic gonadotropin;	The Children's Hospital, Zhejiang University School of Medicine	NULL	Recruiting	3	10	Female	Target condition:200;Difficult condition:100		China
3	ChiCTR2000038202	2020-09-01	2020-09-13	AMH combined INHB for the diagnosis of female central precocious puberty	AMH combined INHB for the diagnosis of female central precocious puberty	Central precocious puberty	Gold Standard:GnRHa provoctive test;Index test:Anti Mullerian hormone, Inhibin B;	Capital Institute of Pediatrics	NULL	Recruiting	5	8	Female	Target condition:150;Difficult condition:150		China
4	ChiCTR2000034464	2020-09-01	2020-07-05	First Morning Voided Urinary Gonadotropin Measurements for the Early Screening, Diagnosis and Follow-up of CPP Patients	First Morning Voided Urinary Gonadotropin Measurements for the Early Screening, Diagnosis and Follow-up of CPP Patients	Central precocious puberty	Gold Standard:Clinical outcome by CPP diagnostic standards;Index test:morning urine GN;	Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology	NULL	Pending	6	12	Both	Target condition:400;Difficult condition:6000		China

84. サルコイドーシス

臨床試験数 : 149 / 薬物数 : 202 - (DrugBank : 78) / 標的遺伝子数 : 66 - 標的パスウェイ数 : 169

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000036043	2020-10-01	2020-08-21	A prospective, single-centre, diagnostic accuracy study of XpertMTB/RIF Ultra to differentiate atypical tuberculosis from sarcoidosis	A prospective, single-centre, diagnostic accuracy study of XpertMTB/RIF Ultra to differentiate atypical tuberculosis from sarcoidosis	sarcoidosis, tuberculosis	Gold Standard:Biopsy pathological specimen, and sputum AFB smear;Index test:XpertMTB/RIF Ultra;	Shanghai Pulmonary Hospital Tongji University, School of Medicine	NULL	Pending	18		Both	Target condition:72;Difficult condition:72		China
2	ChiCTR-DCD-15007110	2015-09-01	2015-09-20	The clinical application of new methods for differential diagnosis of sarcoidosis andsputum negative tuberculosis	The clinical application of new methods for differential diagnosis of sarcoidosis andsputum negative tuberculosis	sarcoidosis andsputum negative tuberculosis	Gold Standard:;Index test:;	Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine	NULL	Recruiting	18		Both	Target condition:0;Difficult condition:0		China

86. 肺動脈性肺高血圧症

臨床試験数 : 1,205 / 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000036852	2020-10-01	2020-08-25	Establishment of an artificial intelligence screening and evaluation system based on multimodal imaging of pulmonary arterial hypertension: Study on clinical diagnosis model	Establishment of an artificial intelligence screening and evaluation system based on multimodal imaging of pulmonary arterial hypertension: Study on clinical diagnosis model	pulmonary arterial hypertension	Gold Standard:Right heart catheterization;Index test:multimodal imaging artificial intelligence screening and evaluation system;	Shanghai Pulmonary Hospital	NULL	Pending			Both	Target condition:1000;Difficult condition:1000		NULL
2	ChiCTR2000032622	2020-05-01	2020-05-04	Research for right cardiac function evaluation and warning model of neonatal pulmonary arterial hypertension	Research for right cardiac function evaluation and warning model of neonatal pulmonary arterial hypertension	pulmonary arterial hypertension	Gold Standard:Clinical outcome;Index test:echocardiographic;	Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital	NULL	Pending			Male	Target condition:100;Difficult condition:0		China
3	ChiCTR1900028152	2020-01-01	2019-12-13	Serum interleukins-6: a predictive biomarker for connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH)	Serum interleukins-6: a predictive biomarker for connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH)	pulmonary arterial hypertension	Gold Standard:Clinical outcome;Index test:serum IL-6;	Zhongda Hospital Affiliated to Southeast University	NULL	Pending	18	80	Both	Target condition:200;Difficult condition:0	N/A	China
4	ChiCTR-DDD-16009406	2016-11-01	2016-10-14	System Construction of Precious Diagnosis and Evaluation for Pulmonary Arterial Hpyertension	System Construction of Precious Diagnosis and Evaluation for Pulmonary Arterial Hpyertension	Pulmonary arterial hypertension	Gold Standard:;Index test:;	Shanghai Pulmonary Hospital	NULL	Pending			Both	Target condition:0;Difficult condition:0		China
5	NCT01457170 (ClinicalTrials.gov)	January 2012	20/10/2011	Effects of Apelin on the Lung Circulation in Pulmonary Hypertension	Investigating the Acute Pulmonary Vascular Haemodynamic Effects of Apelin in Pulmonary Hypertension	Pulmonary Arterial Hypertension;Heart Failure	Drug: Apelin;Drug: Saline (Placebo)	Golden Jubilee National Hospital	NHS Lothian;Imperial College Healthcare NHS Trust	Recruiting	18 Years	N/A	Both	63	N/A	United Kingdom

先頭へ

91. バッド・キアリ症候群

臨床試験数 : 4 / 薬物数 : 5 - (DrugBank : 4) / 標的遺伝子数 : 4 - 標的パスウェイ数 : 14

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800017925	2018-08-31	2018-08-22	D-printed bidirectional angiography versus traditional angiography for the diagnosis and effect of Budd–Chiari Syndrome With Inferior Vena Cava Obstruction:-----A Prospective Single blind Randomized Trial	D-printed bidirectional angiography versus traditional angiography for the diagnosis and effect of Budd–Chiari Syndrome With Inferior Vena Cava Obstruction:-----A Prospective Single blind Randomized Trial	Budd-Chiari syndrome	Gold Standard:traditional angiography;Index test:3D-printed bidirectional angiography;	Affiliated Hospital of Xuzhou Medical University	NULL	Pending	19	68	Both	Target condition:60;Difficult condition:0		NULL

93. 原発性胆汁性胆管炎

臨床試験数 : 298 / 薬物数 : 252 - (DrugBank : 59) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 115

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000040593	2020-12-01	2020-12-03	Prevalence and prognostic risk of primary biliary cholangitis in Yunnan Province	Prevalence and prognostic risk of primary biliary cholangitis in Yunnan Province	primary biliary cholangitis	Gold Standard:PBC can be diagnosed by meeting 2 of the following 3 criteria :(1) serum biochemical indication of increased ALP;(2) When AMA is positive or AMA is negative, other PBC specific autoantibodies, such as SP100 and GP210 are positive;(3) Histological evidence suggested non-suppurative destructive cholangitis and inter-lobu;Index test:AMA in serum of suspected PBC cases was detected by traditional AMA-M2 test and BPO test, respectively.;	The Second Affiliated Hospital of Kunming Medical University	NULL	Pending			Male	Target condition:0;Difficult condition:0	N/A	China
2	ChiCTR2000032053	2020-05-01	2020-04-19	Application value of ultrasonography combined with transient elastography for staging of hepatic fibrosis in patients with primary biliary cholangitis (PBC)	Application value of ultrasonography combined with transient elastography for staging of hepatic fibrosis in patients with primary biliary cholangitis (PBC)	primary biliary cholangitis	Gold Standard:Any two of the following items met: 1. increased biochemical indicators of cholestasis such as alkaline phosphatase; 2. positive serum AMA or AMA-M2; 3. hepatic histopathology.;Index test:high-frequency and low-frequency ultrasound?transient elastography (TE);	You'an Hospital, Capital Medical University	NULL	Pending	18	70	Both	Target condition:100;Difficult condition:270	N/A	China
3	ChiCTR1900024836	2019-07-30	2019-07-30	Exploration of non-invasive diagnostic model of liver fibrosis based on artificial intelligence in primary biliary cholangitis Clinical research protocol	Exploration of non-invasive diagnostic model of liver fibrosis based on artificial intelligence in primary biliary cholangitis Clinical research protocol	Primary biliary cholangitis	Gold Standard:Liver biopsy pathology.;Index test:Non-invasive diagnostic model for liver fibrosis: including AST/PLT value index (APRI model), Forns model, S index, and based on this, a new non-invasive liver fibrosis diagnosis model is generated.;	Beijing You'an Hospital, Capital Medical University	NULL	Recruiting	18	80	Both	Target condition:180;Difficult condition:180		China

95. 自己免疫性肝炎

臨床試験数 : 52 / 薬物数 : 68 - (DrugBank : 27) / 標的遺伝子数 : 18 - 標的パスウェイ数 : 111

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000031051	2020-05-01	2020-03-21	Study on the early diagnosis and prediction model of autoimmune hepatitis based on noninvasive clinical data	Study on the early diagnosis and prediction model of autoimmune hepatitis based on noninvasive clinical data	Autoimmune hepatitis	Gold Standard:liver biopsy;Index test:the early diagnosis and prediction model of autoimmune hepatitis based on noninvasive clinical data;	The Sixth People's Hospital Affiliated To Shanghai Jiaotong University	NULL	Pending			Male	Target condition:238;Difficult condition:0		China

96. クローン病

臨床試験数 : 2,442 / 薬物数 : 1,278 - (DrugBank : 248) / 標的遺伝子数 : 142 - 標的パスウェイ数 : 209

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Countries
1	ChiCTR2000037094	2020-09-01	2020-08-26	Discovery and detection of a novel antigen for Crohn’s disease (CD)	Discovery and detection of a novel antigen for Crohn’s disease (CD)	Inflammatory Bowel Disease	Gold Standard:Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing);Index test:anti-CABP, pANCA, ASCA;	The First Affiliated Hospital of Anhui Medical University	NULL	Completed	18	80	Both	Target condition:100;Difficult condition:100	China
2	ChiCTR2000029543	2020-02-08	2020-02-03	A Model with serum biomarkers to Predict Infliximab Response in Patients with Crohn's Disease	A Model with serum biomarkers to Predict Infliximab Response in Patients with Crohn's Disease	Crohn's Disease	Gold Standard:Histology pathological examination; SES-CD endoscopy score;Index test:ELISA test for multiple serum cytokines;	The First Hospital Affiliated to Sun Yat sen University	NULL	Recruiting			Both	Target condition:350;Difficult condition:0	China
3	ChiCTR1900022728	2019-05-01	2019-04-23	Cohort study combined with omics screening for the early diagnostic markers in Crohn's disease	Cohort study combined with omics screening for the early diagnostic markers in Crohn's disease	Crohn's disease	Gold Standard:Clinical outcome;Index test:Comprehensive serological markers, metabolomics, intestinal microbes, pathological features, imaging features of clinical subclinical CD, combined with clinical and endoscopic features, to explore early diagnosis of CD;	The 7th Medical Center of the PLA General Hospital (Army general hospital)	NULL	Pending			Both	Target condition:310;Difficult condition:160	China
4	ChiCTR-DDT-14004999	2013-07-01	2014-07-17	Endoscopic Ultrasonography (EUS) Helps Differentiate Crohn's Disease from Intestinal Tuberculosis	Endoscopic Ultrasonography (EUS) Helps Differentiate Crohn's Disease from Intestinal Tuberculosis	Crohn's disease and intestinal tuberculosis	Gold Standard:;Index test:;	West China Hospital, Sichuan University	NULL	Completed	16	41	Both	Target condition:0;Difficult condition:0	China

97. 潰瘍性大腸炎

臨床試験数 : 2,630 / 薬物数 : 1,459 - (DrugBank : 265) / 標的遺伝子数 : 144 - 標的パスウェイ数 : 202

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800019676	2018-12-01	2018-11-22	Diagnostic Value of probe-based Confocal Laser Endomicroscopy Score for assessment of numosal healing of ulcerative colitis	Diagnostic Value of probe-based Confocal Laser Endomicroscopy Score for assessment of numosal healing of ulcerative colitis: a single center, prospective cohort study	ulcerative colitis	Gold Standard:Histopathological examination;Index test:1, Gland density (grade) 2. Gland morphology (grade) 3. Vascular changes (grade);	Peking University First Hospital	NULL	Pending	18	80	Both	Target condition:40;Difficult condition:0		China
2	ChiCTR1900023689	2012-03-01	2019-06-07	Comparison of white light endoscopy vs chromoendoscopy in the detection rate of dysplasia and colorectal cancer in ulcerative colitis: A Multicenter Long-term Follow-up Randomized Controlled Trial in China	Comparison of white light endoscopy vs chromoendoscopy in the detection rate of dysplasia and colorectal cancer in ulcerative colitis: A Multicenter Long-term Follow-up Randomized Controlled Trial in China	Ulcerative colitis	Gold Standard:Pathological examination;Index test:1. targeted biopsies were taken from all visible lesions when using white light endoscopy 2. using white light endoscopy, sequential 4-quadrantic random biopsies were taken at every 10-cm intervals colon from disease segments defined by the endoscopist in addition to targeted biopsies from all visible lesions; 3. tar;	Xijing Hospital of Digestive Diseases, Fourth Military Medical University	NULL	Completed	18	70	Both	Target condition:141;Difficult condition:0	N/A	China

98. 好酸球性消化管疾患

臨床試験数 : 172 / 薬物数 : 149 - (DrugBank : 39) / 標的遺伝子数 : 38 - 標的パスウェイ数 : 135

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-DOD-16009003	2016-08-04	2016-08-10	Perspective Study On Eosinophilic Gastroenteritis	Perspective Study On Eosinophilic Gastroenteritis	Eosinophilic Gastroenteritis	Gold Standard:;Index test:;	Endoscopy Center, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University.	NULL	Recruiting			Both	Target condition:0;Difficult condition:0		China

113. 筋ジストロフィー

臨床試験数 : 646 / 薬物数 : 471 - (DrugBank : 105) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 170

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800018340	2018-09-12	2018-09-12	Clinical study for cardiac MRI in evaluating early myocardial lesions in patients with muscular dystrophy	Clinical study for cardiac MRI in evaluating early myocardial lesions in patients with muscular dystrophy	Muscular dystrophy	Gold Standard:Genomic sequencing, muscle biopsy;Index test:Myocardial strain, T1/T2mapping value, late delayed enhancement (LGE), myocardial first pass perfusion;	Department of Radiology, West China Second Hospital, Sichuan University	NULL	Recruiting	4	18	Male	Target condition:200;Difficult condition:30		China

137. 限局性皮質異形成

臨床試験数 : 9 / 薬物数 : 5 - (DrugBank : 3) / 標的遺伝子数 : 1 - 標的パスウェイ数 : 51

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100046183	2020-01-01	2021-05-08	Multimodal Neuroimaging-based Cross-site and Cross-protocol Automated Detection of Focal Cortical Dysplasia	Multimodal Neuroimaging-based Cross-site and Cross-protocol Automated Detection of Focal Cortical Dysplasia	Epilepsy	Gold Standard:Underwent epilepsy surgery with pathological confirmation.;Index test:Automatic model for focal cortical dysplasia using multimodal neuroimaging and deep learning.;	Beijing Tiantan Hospital, Capital Medical University	NULL	Recruiting	6	60	Both	Target condition:240;Difficult condition:0		China

158. 結節性硬化症

臨床試験数 : 112 / 薬物数 : 71 - (DrugBank : 19) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 118

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-DDD-17010586	2016-01-01	2017-02-08	Prenatal diagnosis of tuberous sclerosis by fetal echocardiography combined with high throughput gene sequencing	Prenatal diagnosis of TSC using high-throughput gene sequencing combined with fetal echocardiography	Tuberous sclerosis complex	Gold Standard:A Clinical diagnostic criteria of tuberous sclerosis (TSC) for the postnatal population 1. Definite diagnosis: 2 major features or 1 major feature and 2 minor teatures 2. Possible diagnosis: 1 major feature or 2 minor features [major features: (1) Facial angiofibro or forehead plaque, (2) 'Nontraumatic' periungual&#;Index test:1. Prenatal diagnosis of TSC high-risk fetus by the traditional method (amniocentesis) using the gold standard; 2. Prenatal diagnosis of TSC high-risk fetus by maternal peripheral blood gene detection.;	An Zhen Hospital affiliated to Capital Medical University, Beijing;Beijing Key Laboratory of Fetal Heart Diseases and Maternal-Fetal Medicine	NULL	Recruiting			Female	Target condition:30;Difficult condition:5		China

162. 類天疱瘡（後天性表皮水疱症を含む。）

臨床試験数 : 90 / 薬物数 : 122 - (DrugBank : 47) / 標的遺伝子数 : 34 - 標的パスウェイ数 : 144

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800017560	2018-08-31	2018-08-04	Association of serum D-dimer and PDF with the BP severity	Association of serum D-dimer and PDF with the BP severity	Bullous pemphigoid	Gold Standard:Clinical outcome;Index test:D-dimer, FDP, anti-BP180 IgG;	the Second Affiliated Hospital, Xi'an Jiaotong University	NULL	Pending	18	90	Both	Target condition:160;Difficult condition:0		China

167. マルファン症候群

臨床試験数 : 21 / 薬物数 : 40 - (DrugBank : 11) / 標的遺伝子数 : 10 - 標的パスウェイ数 : 50

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100054172	2021-12-31	2021-12-10	Investigation of the value of IMPATT method in the diagnosis of marfan syndrome	A single center, double-blind, diagnostic study on evaluating the value of IMPATT method in the diagnosis of marfan syndrome	Marfan Syndrome	Gold Standard:The 2010 revised Ghent II diagnostic criteria.;Index test:IMPATT alone, single department (cardiology/surgery, ophthalmology, orthopedics), MDT (cardiology/surgery + ophthalmology + orthopedics), IMPATT combined.;	The First Affiliated Hospital of Gannan Medical College	NULL	Pending	0	80	Both	Target condition:30;Difficult condition:165	N/A	China

171. ウィルソン病

臨床試験数 : 79 / 薬物数 : 77 - (DrugBank : 17) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 30

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1900023410	2019-06-01	2019-05-26	The application of quantitative susceptibility mapping and blood and urine cell culture in Wilson's disease	The application of quantitative susceptibility mapping and blood and urine cell culture in Wilson's disease	Wilson’s disease	Gold Standard:The main clinical diagnostic criteria: 1) liver disease history, liver disease symptoms or extravertebral system symptoms; 2) serum ceruloplasmin was significantly decreased and/or liver copper increased; 3) corneal Kayser-Fleischer ring; 4) positive family history.;Index test:Quantitative susceptibility mapping;	Shanghai Tongren Hospital	NULL	Recruiting			Both	Target condition:40;Difficult condition:20		China
2	ChiCTR-DDD-17010552	2017-01-25	2017-02-04	Genetic diagnosis of Wilson's disease	Genetic diagnosis of Wilson's disease	Wilson Disease	Gold Standard:Clinical symptoms; Family history of genetic; Plasma ceruloplasmin levels;Urine copper levels of 24 hours; The nervous system of assessment and head imaging examination;Index test:Determination of gene sequence of the gene of ATP7B;	Anhui Provincial Hospital	NULL	Recruiting			Both	Target condition:20;Difficult condition:0		China

193. プラダー・ウィリ症候群

臨床試験数 : 113 / 薬物数 : 111 - (DrugBank : 26) / 標的遺伝子数 : 48 - 標的パスウェイ数 : 102

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000039618	2020-12-01	2020-11-03	Diagnostic accuracy of RNA molecular markers in Prader Willi syndrome	Diagnostic accuracy of RNA molecular markers in Prader Willi syndrome	Prader-Willi syndrome	Gold Standard:Methylation specific multiplex ligation probe amplification (MS-MLPA) combined with chromosome G-banding karyotype analysis and array comparative genomic hybridization (array CGH).;Index test:Detection of ribonucleic acid molecular markers.;	Children's Hospital Affiliated to Medical College of Zhejiang University	NULL	Recruiting			Both	Target condition:20;Difficult condition:0		China

218. アルポート症候群

臨床試験数 : 30 / 薬物数 : 36 - (DrugBank : 15) / 標的遺伝子数 : 8 - 標的パスウェイ数 : 46

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000036550	2020-09-01	2020-08-24	Enzyme-linked immunosorbent determination of urine IV collagen alpha chain early warning value for Alport syndrome	Enzyme-linked immunosorbent determination of urine IV collagen alpha chain early warning value for Alport syndrome	Alport syndrome	Gold Standard:Renal biopsy, skin biopsy and genetic test.;Index test:urine IV collagen a chain test;	Children's Hospital of Shanghai	NULL	Recruiting	0	18	Both	Target condition:60;Difficult condition:70		China

222. 一次性ネフローゼ症候群

臨床試験数 : 310 / 薬物数 : 295 - (DrugBank : 117) / 標的遺伝子数 : 63 - 標的パスウェイ数 : 194

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200058162	2022-05-01	2022-03-31	Efficacy of CRS model combining serum anti-PLA2R antibody and GRS score for diagnosis and prognosis of iMN	Efficacy of CRS model combining serum anti-PLA2R antibody and GRS score for diagnosis and prognosis of iMN	Idiopathic membranous nephropathy	Gold Standard:Chronic kidney disease was first diagnosed according to the presence of edema, proteinuria, hypoproteinemia, hyperlipidemia, etc. Kidney biopsy was performed on the basis of chronic kidney disease to obtain kidney tissue, and then pathological examination was performed to confirm the diagnosis of primary nephrotic syndrome;Index test:Serum creatinine, serum albumin, cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, serum IgG, serum IgA, serum IgM, complement C3, complement C4 were determined by blood sampling. 24 hours proteinuria was measured by urine retention. The renal tissue was sectionized, and the pathological diagno;	Yuebei People’s Hospital	NULL	Pending	18		Both	Target condition:50;Difficult condition:50		China
2	ChiCTR2100050481	2021-09-01	2021-08-27	Clinical study of liquid biopsy in membranous nephropathy based on urine exosomal proteome detection	Clinical study of liquid biopsy in membranous nephropathy based on urine exosomal proteome detection	membranous nephropathy	Gold Standard:kidney biopsy;Index test:types and amounts of proteins expressed in exosomes;	Shenzhen Second People's Hospital	NULL	Recruiting	18	90	Both	Target condition:100;Difficult condition:200		China
3	ChiCTR2000037467	2020-12-31	2020-08-28	Effect of Tripterygium wilfordii polyglycoside tablets on the inhibition of TM on complement pathway and related inflammatory markers in membranous nephropathy	The complement pathway and related inflammatory factor markers in the treatment of idiopathic membranous nephropathy	idiopathic membranous nephropathy	Gold Standard:Cell hemolysis test;Index test:Immunochemiluminescence (ECL) and flow cytometry (FCM) were used to determine the activity of each complement pathway and the target of complement; Complement hemolysis test is usually used to determine the activity of total complement and single complement component, but it is difficult to be applied to clinical ;	Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine	NULL	Pending	18	80	Both	Target condition:40;Difficult condition:40		China
4	NCT04387448 (ClinicalTrials.gov)	July 28, 2020	11/5/2020	A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease	A Phase 2a Multiple Ascending, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease	Kidney Diseases;Diabetic Nephropathies;Glomerulosclerosis, Focal Segmental;Nephrosis, Lipoid;Urologic Diseases;Diabetes Complications;Diabetes Mellitus;Endocrine System Diseases;Glomerulonephritis;Nephritis;Nephrosis	Drug: GFB-887;Drug: Placebo	Goldfinch Bio, Inc.	NULL	Terminated	18 Years	75 Years	All	96	Phase 2	United States
5	ChiCTR1900027128	2019-10-30	2019-11-01	Validation of Anti-Phospholipase A2 Receptor Antibody ELISA in a Chinese Cohort With Idiopathic Membranous Nephropathy: a Multicenter Observational Study	The Cut-off Value of Anti-Phospholipase A2 Receptor Antibody ELISA in Chinese Patients	Membranous Nephrology	Gold Standard:Pathological diagnosis according to kidney biopsy(Chapter 7, 7.1 Evaluation of MN, KDIGO 2012);Index test:Serum PLA2R Antibody by ELISA;	Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University	NULL	Recruiting			Both	Target condition:288;Difficult condition:290	N/A	China

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224. 紫斑病性腎炎

臨床試験数 : 16 / 薬物数 : 43 - (DrugBank : 21) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 58

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1800017046	2018-07-15	2018-07-10	The research of Gd - IgA1 with purpura nephritis	The research of Gd - IgA1 with purpura nephritis	Henoch-Schnlein purpura nephritis;D69.005+	Gold Standard:Allergic purpura diagnostic criteria: 1) the tangibility purpura; 2) the onset age < 20 years old; 3) with acute abdominal pain; 4) biopsy showed small veins and arteries around a neutrophil infiltration. In the above four standard, conform to article 2 or above can be diagnosed as allergic purpura. Purpur;Index test:Gd-IgA1, IgA, IgG, C3;	College of Pediatrics, University of South China/Children's Hospital of Hu'nan Province	NULL	Recruiting	1	14	Both	Target condition:250;Difficult condition:24		China

226. 間質性膀胱炎（ハンナ型）

臨床試験数 : 145 / 薬物数 : 156 - (DrugBank : 51) / 標的遺伝子数 : 64 - 標的パスウェイ数 : 146

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100051474	2021-09-15	2021-09-24	Urinary Galectin-3 and CXCL-7 as biomarkers for diagnosing interstitial cystitis and correlation with clinical characteristics	Urinary Galectin-3 and CXCL-7 as biomarkers for diagnosing interstitial cystitis and correlation with clinical characteristics	interstitial cystitis	Gold Standard:Suprapubic pain, pressure or discomfort, pressure, or discomfort related to bladder filling, accompanied by urgency, frequency, etc., for more than 6 months.;Index test:Both interstitial cystitis patients with or without Hunner’s ulcers were recruited in the study, while healthy subjects were involved as controls. Then we collected urine samples from all the involved subjects, and the CXCL-7 level and Galectin-3 level in the supernatants of urine were measured by ELISA. ;	Hebei People's Hospital	NULL	Pending			Both	Target condition:50;Difficult condition:50		China

227. オスラー病

臨床試験数 : 56 / 薬物数 : 72 - (DrugBank : 21) / 標的遺伝子数 : 23 - 標的パスウェイ数 : 136

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR1900027420	2018-01-01	2019-11-12	genetic screening for hereditary hemorrhagic telangiectasia	Investigation and applyling on the genetic screening kit for hereditary hemorrhagic telangiectasia	hereditary hemorrhagic telangiectasia	Gold Standard:Clinical outcomes;Index test:To identified the pathogenic variant through genetic testing for the coding region of ENG, ACVRL1, SMAD4 and BMP9.;	Beijing Institute of Otolaryngology	NULL	Recruiting			Both	Target condition:54;Difficult condition:0		China

230. 肺胞低換気症候群

臨床試験数 : 6 / 薬物数 : 7 - (DrugBank : 4) / 標的遺伝子数 : 16 - 標的パスウェイ数 : 26

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-DDT-11001215	2010-07-01	2011-03-05	Double position CT investigation of OSAHS	Double position CT investigation of OSAHS	Obstructive sleep apnea hypoventilation syndrome	Gold Standard:;Index test:;	First Hospital of Peking university	NULL	Completed			Both	Target condition:0;Difficult condition:0		China

271. 強直性脊椎炎

臨床試験数 : 574 / 薬物数 : 359 - (DrugBank : 68) / 標的遺伝子数 : 41 - 標的パスウェイ数 : 146

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-DDD-17014196	2018-01-01	2017-12-28	HLA-B27 tested by different methods and comparison	HLA-B27 tested by different methods and comparison	Ankylosing spondylitis	Gold Standard:Detect HLA-B27 by cytometry;Index test:SSP and SSO;	Dalian Blood Center	NULL	Recruiting	5	90	Both	Target condition:200;Difficult condition:0		China

291. ヒルシュスプルング病（全結腸型又は小腸型）

臨床試験数 : 12 / 薬物数 : 24 - (DrugBank : 15) / 標的遺伝子数 : 0 - 標的パスウェイ数 : 0

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000035860	2020-10-01	2020-08-18	Artificial intelligence for pathological grading system of ganglion cells for intraoperative rapid biopsy in Hirschsprung disease	Artificial intelligence for pathological grading system of ganglion cells for intraoperative rapid biopsy in Hirschsprung disease	Hirschsprung disease	Gold Standard:The speciemens and sections will be reveiwed by three senior pediatric gastroenterology pathologists under the novel pathological grading system of ganglion cells in Hirschsprung disease, and the results is regarded as the gold standard.;Index test:Artificial intelligence assisted whole-section patholgic diagnosis system;	Xinhua Hospital, Shanghai Jiaotong University School of Medicine	NULL	Pending	0	16	Both	Target condition:138;Difficult condition:138		China

296. 胆道閉鎖症

臨床試験数 : 71 / 薬物数 : 70 - (DrugBank : 39) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 60

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2200059705	2022-05-01	2022-05-08	Machine Learning Based on Sonographic Gallbladder Images in Prenatal Diagnosis of Biliary Atresia	Machine Learning Based on Sonographic Gallbladder Images in Prenatal Diagnosis of Biliary Atresia	Biliary atresia	Gold Standard:Surgical exploration, puncture biopsy, intraoperative cholangiography, or percutaneous cholecystography ;Index test:Intelligent prenatally diagnostic system based on sonographic gallbladder images;	Shengjing Hospital of China Medical University	NULL	Pending			Female	Target condition:2000;Difficult condition:0		China
2	ChiCTR2200055459	2022-02-01	2022-01-10	Establishment of a diagnostic model of biliary atresia ultrasound combined with MMP-7: a multicenter diagnostic accuracy study	Establishment of a diagnostic model of biliary atresia ultrasound combined with MMP-7: a multicenter diagnostic accuracy study	Biliary atresia	Gold Standard:Biliary tract exploration and liver pathology.;Index test:MMP-7, ultrasound, MMP-7 and ultrasound combined diagnostic model.;	Pediatric Hospital Affiliated to Fudan University	NULL	Recruiting			Both	Target condition:150;Difficult condition:150		China
3	ChiCTR2100053800	2021-12-13	2021-11-29	Multimodal Magnetic Resonance Imaging for Evaluating the Developmental State of Bile Ducts and the Degree of Hepatic Fibrosis in Children with Biliary Atresia	Multimodal Magnetic Resonance Imaging for Evaluating the Developmental State of Bile Ducts and the Degree of Hepatic Fibrosis in Children with Biliary Atresia	Biliary Atresia	Gold Standard:Intraoperative cholangiography is often considered the diagnostic gold standard for biliary atresia. Blood biochemical examination is used as a reference standard for evaluating liver fibrosis.;Index test:Multimodal Magnetic Resonance Imaging;	Children's Hospital of Chongqing Medical University	NULL	Recruiting			Both	Target condition:100;Difficult condition:0		China
4	ChiCTR2100044533	2021-06-01	2021-03-23	Multicenter study of non-invasive diagnostic scoring system for biliary atresia	Multicenter study of non-invasive diagnostic scoring system for biliary atresia	Biliary atresia	Gold Standard:Intraoperative cholangiography;Index test:Non-invasive diagnostic scoring system for biliary atresia (Biochemicaltests, blood routine, CRP, blood ammonia, AFP, hepatobiliary B ultrasound);	Children's Hospital Affiliated to Zhejiang University Medical College	NULL	Recruiting			Both	Target condition:200;Difficult condition:0		China
5	ChiCTR2000032983	2020-08-01	2020-05-17	Development of Biomarkers for Biliary Atresia and Establishment of Artificial Intelligence Diagnostic Model	Development of Biomarkers for Biliary Atresia and Establishment of Artificial Intelligence Diagnostic Model	Biliary atresia	Gold Standard:Cholangiography combined with liver biopsy;Index test:MMP7;bile acid profile;	Children's Hospital of Fudan University	NULL	Recruiting			Both	Target condition:600;Difficult condition:600		China
6	ChiCTR2000034127	2020-07-20	2020-06-25	Application of MMP-7 in early diagnosis of neonatal biliary atresia	Application of MMP-7 in early diagnosis of neonatal biliary atresia	Biliary atresia disease	Gold Standard:Laparoscopic cholangiography;Index test:Serum MMP-7;	Department of Pediatric Surgery, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology	NULL	Pending		0.1	Both	Target condition:300;Difficult condition:0		China
7	ChiCTR1800019866	2019-01-01	2018-12-02	Development and validation of novel diagnostic model for biliary atresia	Development and validation of novel diagnostic model for biliary atresia: a multicenter diagnostic test	biliary atresia	Gold Standard:cholangiography combined with liver biopsy;Index test:Nomogram;	Children's Hospital of Fudan University	NULL	Pending			Both	Target condition:1000;Difficult condition:200		China
8	ChiCTR1800017428	2018-08-15	2018-07-30	Machine learning based on the gallbladder morphology for screening biliary atresia among infants with conjugated hyperbilirubinemia	Machine learning based on the gallbladder morphology for screening biliary atresia among infants with conjugated hyperbilirubinemia	Biliary atresia	Gold Standard:Surgical exploration, puncture biopsy, intraoperative cholangiography or percutaneous cholecystography;Index test:machine learning based on the gallbladder morphology;	Department of Medical Ultrasonics, the First Affiliated Hospital of Sun Yat-sen University	NULL	Pending			Both	Target condition:500;Difficult condition:100		China
9	ChiCTR-DPD-15005847	2014-11-19	2015-01-19	Evidence-based guideline of diagnosis and treatment of biliary atresia	Evidence-based guideline of diagnosis and treatment of biliary atresia	biliary atresia	Gold Standard:;Index test:;	Children's Hospital of Fudan University	NULL	Pending	0	18	Both	Target condition:0;Difficult condition:0	I (Phase 1 study)	China

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298. 遺伝性膵炎

臨床試験数 : 95 / 薬物数 : 148 - (DrugBank : 51) / 標的遺伝子数 : 53 - 標的パスウェイ数 : 142

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000037002	2020-10-01	2020-08-26	Differential diagnosis of pancreatic cancer and chronic pancreatitis with serum miR-25	A prospective study of serum miR-25 detection in differential diagnosis of pancreatic cancer and chronic pancreatitis	pancreatic cancer	Gold Standard:Pancreatic cancer: pancreatic ductal adenocarcinoma originating from pancreatic ductal epithelium was confirmed by pathological examination (operative biopsy, puncture biopsy, cytological examination). Chronic pancreatitis: Clinically diagnosed as chronic pancreatitis, and no evidence to support the diagnosis of pancreatic cancer.;Index test:Serum miR-25;	The First Affiliated Hospital of the Naval Medical University of the Chinese People's Liberation Army	NULL	Pending	18	75	Both	Target condition:150;Difficult condition:150		China

310. 先天異常症候群

臨床試験数 : 11 / 薬物数 : 20 - (DrugBank : 10) / 標的遺伝子数 : 3 - 標的パスウェイ数 : 7

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000035477	2020-08-11	2020-08-12	Clinical study on the diagnosis of Smith Lemli Opitz syndrome by GC-MS	Clinical study on the diagnosis of Smith Lemli Opitz syndrome by GC-MS	Smith-Lemli-Opitz syndrome	Gold Standard:Quantitative detection of 7-DHC;Index test:Detection of chol and 7-DHC in clinical samples by GC-MS;	Obstetrics and Gynecology Hospital Affiliated to Fudan University	NULL	Pending	0	1	Both	Target condition:110;Difficult condition:0		China

318. シトリン欠損症

臨床試験数 : 2 / 薬物数 : 2 - (DrugBank : 2) / 標的遺伝子数 : 0 - 標的パスウェイ数 : 0

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000038114	2020-09-15	2020-09-11	Molecular Diagnostic Study and Clinical Management of citrin deficiency	Molecular Diagnostic Study and Clinical Management of citrin deficiency	Citrin deficiency	Gold Standard:Sanger sequncing;Index test:Next-Generation Sequncing;	Beijing Friendship Hospital Affiliated to Capital Medical University	NULL	Recruiting			Both	Target condition:60;Difficult condition:0	N/A	China

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