Amitriptylin ( DrugBank: Amitriptylin )

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1 disease

告示番号	疾患名（ページ内リンク）	臨床試験数
299	嚢胞性線維症	4

299. 嚢胞性線維症

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臨床試験数 : 1,695 /  薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01309178 (ClinicalTrials.gov)	May 2009	4/3/2011	Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	Anti-inflammatory Pulmonal Therapy of CF Patients With Amitriptyline and Placebo - a Randomised, Double-blind, Placebo-controlled, Multicenter, Cohort - Study	Cystic Fibrosis;Pneumonia	Drug: Amitriptyline;Drug: Mannite	University Children’s Hospital Tuebingen	Universität Duisburg-Essen;University of Ulm	Recruiting	14 Years	65 Years	Both	30	Phase 2	Germany
2	EUCTR2006-002259-33-DE (EUCTR)	10/10/2006	11/07/2006	Protocol for a Phase II-studyAnti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo - a randomised, double-blinded, placebo-controlled, cross over study -	Protocol for a Phase II-studyAnti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo - a randomised, double-blinded, placebo-controlled, cross over study -	CF-patients develop a chronic pulmonary infection with Pseudomonas aeruginosa (P. aeruginosa). At present it is unknown why CF-patients are highly sensitive to P. aeruginosa infections and, most important, no curative treatment for cystic fibrosis is available. This Study should provide a novel anti-inflammatory treatment for cystic fibrosis, which reduces pulmonary complications, progression of the disease and may possibly increase the life-expectance of the patients.	Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE Trade Name: Amitriptylin-ct Tabletten Product Name: Amitriptyline INN or Proposed INN: AMITRIPTYLINE	Paediatrisches Sekretariat fuer Klinische Studien	NULL	Not Recruiting			Female: yes Male: yes	18	Phase 2	Germany
3	NCT00515229 (ClinicalTrials.gov)	October 2006	9/8/2007	Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo	Protocol for a Phase II-Study Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo - Randomised, Double-Blinded, Placebo-Controlled, Cross Over - Study -	Cystic Fibrosis;Infection;Pseudomonas Aeruginosa	Drug: amitriptyline	University Hospital Tuebingen	NULL	Completed	18 Years	50 Years	Both	18	Phase 2	Germany
4	EUCTR2008-002673-13-DE (EUCTR)		27/08/2008	Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo	Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo	Deficiency of the Cftr-molecule results in accumulation of ceramide in respiratory epithelial cells. Ceramide triggers a pro-inflammatory and -apoptotic status in cystic fibrosis patients. Amitriptyline reduces ceramide levels in the lung tissue, normalises the activity of cytokines and prevents constitutive cell death of epithelial cells. Amitriptyline prevents pulmonary infections of CF-mice with P. aeruginosa. Amitriptyline may result in an improved lung function of cystic fibrosis patients.	Trade Name: Amitriptylin-CT Product Name: Amitriptyline INN or Proposed INN: Amitriptyline	PSKS	NULL	Not Recruiting			Female: yes Male: yes		Phase 2	Germany