N91115 ( DrugBank: - )


1 disease
告示番号疾患名(ページ内リンク)臨床試験数
299嚢胞性線維症5

299. 嚢胞性線維症


臨床試験数 : 1,695 薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT02934139
(ClinicalTrials.gov)
October 201610/10/2016MAD Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Cavosonstat (N91115) in Healthy Subjects (SNO-9)A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of N91115 in Healthy SubjectsCystic FibrosisDrug: Cavosonstat;Other: PlaceboNivalis Therapeutics, Inc.NULLCompleted18 Years55 YearsAll32Phase 1United States
2NCT02724527
(ClinicalTrials.gov)
April 201611/3/2016Study of Cavosonstat (N91115) in CF Patients Who Are Heterozygous for F508del-CFTR and a Gating Mutation and Being Treated With IvacaftorA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of N91115 for Efficacy and Safety in Patients With CF Heterozygous for F508del-CFTR + Gating Mutation Being Treated With IvacaftorCystic FibrosisDrug: Cavosonstat;Drug: PlaceboNivalis Therapeutics, Inc.NULLActive, not recruiting18 YearsN/ABoth19Phase 2United States
3NCT02589236
(ClinicalTrials.gov)
November 201526/10/2015Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR MutationA Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of N91115 to Evaluate Efficacy and Safety in Patients With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation Treated With Lumacaftor/IvacaftorCystic FibrosisDrug: Cavosonstat;Drug: PlaceboNivalis Therapeutics, Inc.Medidata SolutionsCompleted18 YearsN/AAll138Phase 2United States
4NCT02275936
(ClinicalTrials.gov)
February 201514/10/2014Study of N91115 in Patients With Cystic Fibrosis Homozygous F508del-CFTR MutationA Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Study of N91115 to Evaluate Safety and Pharmacokinetics in Patients With Cystic Fibrosis Homozygous for the F508del-CFTR MutationCystic FibrosisDrug: N91115Nivalis Therapeutics, Inc.NULLCompleted18 Years80 YearsBoth51Phase 1United States
5NCT02227888
(ClinicalTrials.gov)
October 201426/8/2014PK Study of N91115 in Cystic Fibrosis PatientsA Phase 1, Open-Label Study Evaluating the Pharmacokinetics of N91115 in Cystic Fibrosis PatientsCystic FibrosisDrug: N91115Nivalis Therapeutics, Inc.NULLCompleted18 YearsN/ABoth6Phase 1United States