Itraconazole ( DrugBank: Itraconazole )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
3	脊髄性筋萎縮症	1
46	悪性関節リウマチ	1
65	原発性免疫不全症候群	1
96	クローン病	1
227	オスラー病	1
299	嚢胞性線維症	5

3. 脊髄性筋萎縮症

臨床試験数 : 237 / 薬物数 : 123 - (DrugBank : 29) / 標的遺伝子数 : 51 - 標的パスウェイ数 : 75

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02633709 (ClinicalTrials.gov)	January 7, 2016	15/12/2015	A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam ...	A Single-Center, Randomized, Investigator/Subject-Blind, Adaptive Single-Ascending-Dose(SAD), Placeb ...	Spinal Muscular Atrophy	Drug: Itraconazole;Other: Placebo;Drug: Risdiplam	Hoffmann-La Roche	NULL	Completed	18 Years	45 Years	Male	33	Phase 1	Netherlands

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46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05404724 (ClinicalTrials.gov)	June 25, 2022	31/5/2022	Study on the Pharmacokinetic Effect of Itraconazole on SHR0302 Tablets in Healthy Subjects	Study on the Pharmacokinetic Effects of Single-centered, Open, Single-arm, Fixed-sequence Itraconazo ...	Rheumatoid Arthritis	Drug: itraconazole? SHR0302 tablets	Jiangsu HengRui Medicine Co., Ltd.	NULL	Completed	18 Years	45 Years	Male	14	Phase 1	China

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65. 原発性免疫不全症候群

臨床試験数 : 500 / 薬物数 : 614 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 217

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00001280 (ClinicalTrials.gov)	January 1991	3/11/1999	Itraconazole for the Prevention of Fungal Infections in Chronic Granulomatous Disease	Itraconazole for the Prevention of Fungal Infections in Chronic Granulomatous Disease	Mycoses	Drug: itraconazole	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Completed	N/A	N/A	Both	100	Phase 2	United States

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96. クローン病

臨床試験数 : 2,442 / 薬物数 : 1,278 - (DrugBank : 248) / 標的遺伝子数 : 142 - 標的パスウェイ数 : 209

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05049525 (ClinicalTrials.gov)	February 22, 2022	25/8/2021	Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease	Evaluation of the Response of Itraconazoleand Terbinafine Therapy in Subjects With Crohn's Disease N ...	Crohn's Disease;Inflammatory Bowel Diseases	Drug: Itraconazole400 mg/day and terbinafine 500 mg/day administered orally.;Drug: Itraconazole's ma ...	Montreal Heart Institute	NULL	Recruiting	18 Years	65 Years	All	68	Phase 2	Canada

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227. オスラー病

臨床試験数 : 56 / 薬物数 : 72 - (DrugBank : 21) / 標的遺伝子数 : 23 - 標的パスウェイ数 : 136

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2017-003272-31-NL (EUCTR)	18/05/2018	11/01/2018	Itraconazoleas treatment for severe nose bleeding in patients with hereditary hemorrhagic telangiect ...	Efficacy and safety of oral itraconazolein the reduction of epistaxis severity in hereditary hemorrh ...	Severe epistaxis in patients with Hereditary Hemorrhagic Telangiectasia also known as Rendu-Osler-We ...	Trade Name: Sporanox Product Name: Itraconazole	St. Antonius Ziekenhuis	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	25	Phase 2	Netherlands

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299. 嚢胞性線維症

臨床試験数 : 1,695 / 薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01576315 (ClinicalTrials.gov)	June 2014	29/3/2012	ATCF (Azole Therapy in Cystic Fibrosis)	Efficacy of Itraconazoleand of Voriconazole in Patients With Cystic Fibrosis and Presenting With Per ...	Cystic Fibrosis;Aspergillus Infections	Drug: Itraconazole/voriconazole	Rennes University Hospital	NULL	Completed	12 Years	N/A	Both	11	Phase 2	France;United Kingdom
2	NCT01768663 (ClinicalTrials.gov)	January 2013	11/1/2013	A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on ...	A Phase 1, Open-Label Study to Examine the Effect of Ciprofloxacin, Itraconazole, and Rifampin on th ...	Cystic Fibrosis	Drug: Lumacaftor;Drug: Ivacaftor;Drug: Ciprofloxacin;Drug: Itraconazole;Drug: Rifampin	Vertex Pharmaceuticals Incorporated	NULL	Completed	18 Years	55 Years	Both	80	Phase 1	United States
3	EUCTR2011-005799-41-GB (EUCTR)	04/10/2012	21/08/2012	Azole Therapy in Cystic Fibrosis (ATCF)	Azole Therapy in Cystic Fibrosis (ATCF) : Efficacy of itraconazoleand ofvoriconazole in patients wit ...	Cystic fibrosis MedDRA version: 14.1;Level: PT;Classification code 10011762;Term: Cystic fibrosis;Sy ...	Trade Name: SPORANOX Product Name: Sporanox 10 mg/ml Oral Solution INN or Proposed INN: ITRACONAZOLE Ot ...	CHU de Rennes (Rennes University Hospital Centre)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	150		United Kingdom
4	NCT00787917 (ClinicalTrials.gov)	November 2008	7/11/2008	An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complic ...	An Exploratory, Randomized, Double-blind, Placebo Controlled Study to Assess the Efficacy of Multipl ...	Cystic Fibrosis;Allergic Bronchopulmonary Aspergillosis	Drug: Omalizumab;Drug: Placebo;Drug: Itraconazole	Novartis Pharmaceuticals	NULL	Terminated	12 Years	N/A	All	14	Phase 4	Belgium;Germany;Italy;Netherlands;United Kingdom
5	NCT00528190 (ClinicalTrials.gov)	October 2007	10/9/2007	Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis	Treatment of Aspergillus Fumigatus in Patients With Cystic Fibrosis: A Randomized, Double-blind, Pla ...	Cystic Fibrosis	Drug: Itraconazole	Ottawa Hospital Research Institute	The Hospital for Sick Children;Canadian Cystic Fibrosis Foundation;The Physicians' Services Incorpor ...	Completed	6 Years	N/A	All	35	Phase 4	Canada

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