SULFASALAZINE ( DrugBank: Sulfasalazine )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
46	悪性関節リウマチ	32
86	肺動脈性肺高血圧症	1
94	原発性硬化性胆管炎	1
107	若年性特発性関節炎	2
270	慢性再発性多発性骨髄炎	1
271	強直性脊椎炎	22

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03813771 (ClinicalTrials.gov)	March 2019	12/9/2018	Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patient ...	Targeted Treatment Early With Etanercept Plus Methotrexate Versus T2T Care for DMARD-naïve Early RA ...	Rheumatoid Arthritis	Drug: Benepali;Drug: Sulfasalazine;Drug: Methotrexate;Drug: Hydroxychloroquine	University of Leeds	Samsung Bioepis Co., Ltd.	Not yet recruiting	18 Years	N/A	All	106	Phase 4	United Kingdom
2	NCT03449758 (ClinicalTrials.gov)	March 5, 2018	8/2/2018	Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis	Effect of Sarilumab on Patient-reported Outcomes in Patients With Moderately to Severely Active Rheu ...	Rheumatoid Arthritis	Drug: SARILUMAB;Drug: Azathioprine;Drug: Chloroquine;Drug: Hydroxychloroquine;Drug: Leflunomide;Drug ...	Sanofi	Regeneron Pharmaceuticals	Completed	18 Years	N/A	All	84	Phase 4	France
3	NCT03440892 (ClinicalTrials.gov)	November 1, 2017	14/2/2018	Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis Patients	Longitudinal Observational Study on Rheumatoid Arthritis Patients: Effects of Antirheumatic Treatmen ...	Rheumatoid Arthritis	Drug: methotrexate;Drug: sulfasalazine;Drug: abatacept;Drug: tocilizumab;Drug: tofacitinib/baricitin ...	Vastra Gotaland Region	NULL	Recruiting	20 Years	N/A	All	2500		Sweden
4	NCT02930343 (ClinicalTrials.gov)	September 2016	13/9/2016	Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate ...	Comparison of SulfasalazineVersus Leflunomide Based Combination Disease Modifying Anti-rheumatic Dru ...	Rheumatoid Arthritis	Drug: Methotrexate;Drug: Leflunomide;Drug: Hydroxychloroquine;Drug: Prednisolone;Drug: Folic Acid;Dr ...	Jawaharlal Institute of Postgraduate Medical Education & Research	NULL	Terminated	18 Years	65 Years	All	136	Phase 3	India
5	NCT02320630 (ClinicalTrials.gov)	October 2015	16/12/2014	Combination Therapy Prevents the Relapse of RA	The Efficacy, Safety and Cost-effectiveness of Hydroxychloroquine, Sulfasalazine, Methotrexate Tripl ...	Recurrence (Disease Attribute)	Drug: Entanercept;Drug: HCQ;Drug: MTX	Peking University First Hospital	Peking University People's Hospital;Peking University Third Hospital;Beijing Hospital;Beijing Jishui ...	Recruiting	18 Years	70 Years	All	240	N/A	China
6	NCT02451748 (ClinicalTrials.gov)	August 2015	6/5/2015	IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZ ...	IL-7 and IL-7R Expression in Peripheral Blood Mononuclear Cells, Peripheral Blood Monocytes or Diffe ...	Rheumatoid Arthritis	Other: Lab Work;Drug: Certolizumab pegol (CDP870, tradename Cimzia)(prefilled syringes at the dose o ...	University of Illinois at Chicago	UCB Pharma	Completed	18 Years	N/A	All	32	Phase 4	United States
7	EUCTR2011-004720-35-NO (EUCTR)	04/05/2015	26/01/2015	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	Rheumatoid arthritis (RA) MedDRA version: 18.0;Level: PT;Classification code 10039073;Term: Rheumato ...	Trade Name: Cimzia INN or Proposed INN: CERTOLIZUMAB PEGOL Trade Name: Orencia INN or Proposed INN: ABA ...	Karolinska Institutet	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	800	Phase 4	Finland;Denmark;Norway;Sweden
8	NCT02373202 (ClinicalTrials.gov)	February 2015	12/2/2015	A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in ...	A Randomized, Double-blind, Multicenter Study Evaluating the Safety and Efficacy of Sarilumab Added ...	Rheumatoid Arthritis	Drug: Sarilumab;Drug: Sulfasalazine;Drug: Leflunomide;Drug: Bucillamine;Drug: Tacrolimus;Drug: Mizor ...	Sanofi	Regeneron Pharmaceuticals	Completed	20 Years	N/A	All	91	Phase 3	Japan
9	EUCTR2011-004720-35-FI (EUCTR)	10/09/2014	09/09/2014	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	Rheumatoid arthritis (RA) MedDRA version: 17.0;Level: PT;Classification code 10039073;Term: Rheumato ...	Trade Name: Cimzia INN or Proposed INN: CERTOLIZUMAB PEGOL Trade Name: Orencia INN or Proposed INN: ABA ...	Karolinska Institutet	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 4	Finland;Denmark;Sweden
10	NCT02057250 (ClinicalTrials.gov)	March 2014	31/1/2014	To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthri ...	A Multicenter, Randomized, Open-Label, Parallel-Group Usability Study Of The Sarilumab Auto-Injector ...	RA	Drug: Sarilumab;Device: Auto-Injector Device (AID);Device: Pre-filled Syringe (PFS);Drug: Methotrexa ...	Sanofi	Regeneron Pharmaceuticals	Completed	18 Years	N/A	All	217	Phase 3	United States;Chile;Mexico;Poland;Russian Federation;South Africa;France

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86. 肺動脈性肺高血圧症

臨床試験数 : 1,205 / 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04528056 (ClinicalTrials.gov)	August 1, 2020	14/8/2020	Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension	Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension	Pulmonary Arterial Hypertension	Drug: Sulfasalazine;Drug: Ambrisentan;Drug: Sulfasalazine's placebo;Drug: Ambrisentan's placebo	RenJi Hospital	NULL	Recruiting	18 Years	75 Years	All	80	Phase 1/Phase 2	China

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94. 原発性硬化性胆管炎

臨床試験数 : 148 / 薬物数 : 118 - (DrugBank : 39) / 標的遺伝子数 : 18 - 標的パスウェイ数 : 141

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03561584 (ClinicalTrials.gov)	July 1, 2018	14/5/2018	Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis	A Randomized, Placebo-controlled Pilot Study of Sulfasalazinefor the Treatment of Primary Sclerosing ...	Primary Sclerosing Cholangitis	Drug: Sulfasalazine;Drug: Placebo	Brigham and Women's Hospital	NULL	Recruiting	15 Years	80 Years	All	42	Phase 2	United States

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107. 若年性特発性関節炎

臨床試験数 : 447 / 薬物数 : 297 - (DrugBank : 57) / 標的遺伝子数 : 52 - 標的パスウェイ数 : 146

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2014-003260-20-NL (EUCTR)	04/05/2016	17/11/2015	CHAMP Trial: comparing monotherapy and polytherapy treatment strategies in newly diagnosed juvenile ...	CHAMP: Children with Arthritis: Monotherapy or Polytherapy. A multicentre, single-blinded, randomize ...	Juvenile idiopathic arthritis;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]	Trade Name: Methotrexate INN or Proposed INN: METHOTREXATE Other descriptive name: METHOTREXATE Trade N ...	Leiden University Medical Centre	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	130	Phase 4	Netherlands
2	NCT00637780 (ClinicalTrials.gov)	June 2010	11/3/2008	Study To Determine The Pharmacokinetics Of SulfasalazineIn Children With Juvenile Idiopathic Arthrit ...	An Open Label Non-randomized Study To Characterize The Steady State Pharmacokinetics Of Sulfasalazin ...	Arthritis, Juvenile Rheumatoid	Drug: Sulfasalazine	Pfizer	NULL	Terminated	6 Years	17 Years	All	2	Phase 4	United States;Mexico;Canada

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270. 慢性再発性多発性骨髄炎

臨床試験数 : 1 / 薬物数 : 10 - (DrugBank : 9) / 標的遺伝子数 : 6 - 標的パスウェイ数 : 73

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04725422 (ClinicalTrials.gov)	August 1, 2018	18/1/2021	CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)	CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)	Chronic Nonbacterial Osteomyelitis;Chronic Recurrent Multifocal Osteomyelitis	Drug: Methotrexate;Drug: Sulfasalazine;Drug: Leflunomide;Drug: Pamidronate;Drug: Zoledronic acid;Dru ...	Seattle Children's Hospital	Boston Children's Hospital, Boston, MA, USA;Hospital for Special Surgery, New York City, NY, USA;Jos ...	Recruiting	N/A	21 Years	All	2000		United States

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271. 強直性脊椎炎

臨床試験数 : 574 / 薬物数 : 359 - (DrugBank : 68) / 標的遺伝子数 : 41 - 標的パスウェイ数 : 146

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100048756	2021-07-19	2021-07-16	Yunpi Yishen Tongdu for active ankylosing spondylitis: a prospective cohort study	Yunpi Yishen Tongdu for active ankylosing spondylitis: a prospective cohort study	ankylosing spondylitis	Non-exposed group: Meloxicam tablets, once a day, one tablet at a time. According to the patient's c ...	Zhejiang University of Traditional Chinese Medicine	NULL	Pending	18	65	Both	Non-exposed group:125;Exposed group:125;	N/A	China
2	ITMCTR2100005056	2021-07-19	2021-07-16	Yunpi Yishen Tongdu for active ankylosing spondylitis: a prospective cohort study	Yunpi Yishen Tongdu for active ankylosing spondylitis: a prospective cohort study	ankylosing spondylitis	Non-exposed group: Meloxicam tablets, once a day, one tablet at a time. According to the patient's c ...	Zhejiang University of Traditional Chinese Medicine	NULL	Pending	18	65	Both	Non-exposed group:125;Exposed group:125;	N/A	China
3	ChiCTR2000038277	2020-10-01	2020-09-15	The factor analysis of curative effect of AS and the indications analysis of Long-snake moxibustion ...	The factor analysis of curative effect of AS and the indications analysis of Long-snake moxibustion ...	Ankylosing spondylitis	Trial Group:Long-snake moxibustion;Control Group:Sulfasalazine Enteric-coated Tablets;	Nanchang Hongdu Hospital of TCM	NULL	Recruiting	18	50	Both	Trial Group:20;Control Group:20;	N/A	China
4	ITMCTR2000004152	2020-10-01	2020-09-15	The factor analysis of curative effect of AS and the indications analysis of Long-snake moxibustion ...	The factor analysis of curative effect of AS and the indications analysis of Long-snake moxibustion ...	Ankylosing spondylitis	Trial Group:Long-snake moxibustion;Control Group:Sulfasalazine Enteric-coated Tablets;	Nanchang Hongdu Hospital of TCM	NULL	Recruiting	18	50	Both	Trial Group:20;Control Group:20;	N/A	China
5	NCT04077957 (ClinicalTrials.gov)	October 7, 2019	1/9/2019	Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARD ...	Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARD ...	Ankylosing Spondylitis;Spondyloarthritis	Drug: Methotrexate;Drug: Sulfasalazine;Drug: Hydroxychloroquine;Drug: Etanercept (50mg per week, for ...	Nanfang Hospital of Southern Medical University	NULL	Not yet recruiting	18 Years	50 Years	All	100	Phase 4	China
6	NCT02638896 (ClinicalTrials.gov)	January 2016	20/12/2015	Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis	Efficacy and Safety of Etanercept Dose Reduction in Patients With Ankylosing Spondylitis	Ankylosing Spondylitis	Drug: etanercept (Half-Dose);Drug: etanercept (Full-Dose);Drug: Sulfasalazine;Drug: Celecoxib	Zhixiang Huang	NULL	Not yet recruiting	18 Years	45 Years	Both	100	Phase 4	NULL
7	ChiCTR-TRC-11001274	2010-04-01	2011-01-28	Integrated Traditional Chinese and Western medicine for ankylosing spondylitis	integrated Traditional Chinese and Western medicine for ankylosing spondylitis with Gan-shen deficie ...	ankylosing spondylitis;M45.911	B group:Qiangji Granule placebo, Sulfasalazine, Ibuprofen;C group:Qiangji Granule placebo, Sulfasala ...	School of Chinese Medicine Southern Medical University	NULL	Completed	18	60	Both	B group:120;C group:180;		China
8	NCT02456363 (ClinicalTrials.gov)	November 2009	14/12/2014	Anti-Tumor Necrosis Factor Therapy In Patients With Ankylosing Spondylitis	Anti-Tumor Necrosis Factor Therapy In Patients With Ankylosing Spondylitis—A Registry Project	Ankylosing Spondylitis	Biological: TNF alpha;Drug: NSAIDs and sulfasalazine	Chung Shan Medical University	NULL	Recruiting	18 Years	N/A	Both	300	Phase 2	Taiwan
9	NCT00889694 (ClinicalTrials.gov)	October 2008	27/4/2009	Clinical Study of Tripterygium Capsule to Treat Early Ankylosing Spondylitis	Clinical Study of Tripterygium Capsule to Treat Early Ankylosing Spondylitis: a 12-Week, Multiple Ce ...	Early Ankylosing Spondylitis	Drug: Tripterygium;Drug: Sulfasalazine;Drug: placebo	Sun Yat-sen University	NULL	Enrolling by invitation	18 Years	65 Years	Both	80	Phase 2/Phase 3	NULL
10	EUCTR2005-001549-41-GR (EUCTR)	08/12/2006	10/08/2006	A Randomised, Double-Blind Study Comparing the Safety and Efficacy of Etanercept with Sulphasalazine ...	A Randomised, Double-Blind Study Comparing the Safety and Efficacy of Etanercept with Sulphasalazine ...	Subjects with Ankylosing Spondylitis (AS)	Product Name: Etanercept Product Code: 0881 INN or Proposed INN: Etanercept Other descriptive name: TNR ...	Wyeth Research Division of Wyeth Pharmaceuticals Inc	NULL	Not Recruiting			Female: yes Male: yes	540	Phase 3;Phase 4	Portugal;Greece;Finland;Spain;Ireland;Austria;United Kingdom;Italy;Hungary;Czech Republic;Denmark;Ge ...

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